Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Discomfort manifested by colic-like clinical signs in 2 young mares was presumed to be attributable to ovarian pain associated with follicular enlargement and ovulation. Diagnosis was based on the lack of detectable evidence of gastrointestinal disease, the finding of a large ovarian follicle or recent ovulation, the repetition of signs during several subsequent estrual periods, and the clinical response to pharmacologic suppression of estrus and ovulation. The similarity of the clinical signs in these 2 mares to cyclic intermenstrual pain in women was considered.
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PMID:Colic-like discomfort associated with ovulation in two mares. 369 93

The effect of indomethacin suppositories on both acute urinary colic and urinary calculus, resistant or refractory to conventional therapy with analgesics and spasmolytics was investigated. Fifty-five patients with acute urinary colic refractory to treatment with repeated injections of antispasmodics and analgesics had dramatic or complete pain relief after receiving indomethacin suppositories (100 mg) (P less than 0.01). Fifteen of the 55 patients passed urinary stones within 30 days of treatment with indomethacin. Three out of 30 other patients with renal or ureteric stones were treated with indomethacin suppositories (100 mg) twice daily. Twenty-one of the 30 patients passed their stones within 30 days of treatment. It is concluded that indomethacin suppositories can relieve acute urinary colic resistant to treatment with analgesic/antispasmodic drugs, and facilitate expulsion of urinary calculi. The mechanism of action of indomethacin is discussed in terms of its analgesic and anti-inflammatory effects and its prostaglandin synthesis inhibition.
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PMID:Prostaglandin synthetase inhibition with indomethacin rectal suppositories in the treatment of acute and chronic urinary calculus obstruction. 372 20

The effect of fluid load on pain was estimated in 60 patients with acute ureteral colic treated with 50 mg. intravenous indomethacin. One group received 3 l. fluid intravenously, while in another group all fluids were withheld for 6 hours. Pain was assessed with a visual analogue scale. No intergroup difference in regard to pain was found after 1, 3 and 6 hours of observation.
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PMID:Indomethacin in the treatment of ureteral colic: is fluid restriction necessary? 373 2

Buprenorphine, a new analgesic, was administered at a dose of 0.2 mg by intramuscular injection to 21 patients with acute ureteral colic. The patients consisted of 14 males and 7 females with a mean age of 42. In all cases, the diagnosis was confirmed based on intravenous urography performed after the treatment. In 19 of the 21 patients, colicky pain was reduced at least within one hour after the administration of buprenorphine. No significant changes in the pulse or blood pressure were observed. In 6 patients, mild dizziness or nausea was observed, and none of the patients required withdrawal of the treatment. Clinical use of buprenorphine was considered to the effective and safe in patients with ureteral colic.
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PMID:[Clinical effect of buprenorphine in ureteral colic]. 373 70

Non-steroidal, anti-inflammatory agents (NSAIDs), wellknown inhibitors of prostaglandins, have been used in the treatment of biliary and ureteral pain since the end of the 1970s. The efficacy and tolerance of a new injectable formulation of naproxen sodium in ureteral and biliary pain was investigated in 77 out-patients, observed in an emergency ward, and affected by acute lithiasic symptomatology. Forty-four patients received one 275 mg vial of naproxen sodium intramuscularly, while 33 patients were given one vial at the same dosage intravenously. In 56% of the cases complete relief of pain was achieved within 30 minutes of injection, while in 86% pain was completely relieved or greatly decreased within one hour. Side-effects (nausea, vomiting) occurred in three patients, but were linked to a simultaneous aggravation of the ureteral colic.
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PMID:Treatment of acute pain of ureteral and biliary colic with naproxen sodium administered by the parenteral route. 380 21

Our data show that 1% of patients who required hospital treatment did so due to severe adverse reactions to analgesics. The most frequent adverse reaction was major gastrointestinal bleeding after aspirin, indomethacin, phenylbutazone or naproxen. Thrombocytopenia, second in frequency, was also mainly a complication of aspirin treatment, as was severe vertigo and tinnitus. Allergic reactions and leucopenia or agranulocytosis occurring in single cases only were associated with the use of pyrazolones. Patients with nephropathy were usually taking phenacetin or one of the close derivatives paracetamol or bucetin. Intensive monitoring for adverse reactions to drugs in 6,000 hospitalised patients in medical wards showed that analgesics, although frequently used, did not lead to life-threatening reactions. Gastrointestinal and neurological side effects were the most commonly observed reactions and these occurred more often after aspirin, indomethacin or pentazocine than after dipyrone or tilidine. Preliminary data of an international case-control-study on agranulocytosis and aplastic anaemia suggest that the incidence of agranulocytosis was in the order of 2 to 3 per million users of analgesics per year. Agranulocytosis occurred predominantly with pyrazolones, with a mortality of 1 to 2 per 10 million users per year. A cohort study on the treatment of colic pain in general practice showed that serious events most likely due to adverse reactions to analgesics were bronchospasm, shock fragments or shock. The incidence of these serious events was about 2 in 1,000 treated cases. The relative risk was not increased by treatment with pyrazolones, opioids or other drugs.
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PMID:Rare but serious risks associated with non-narcotic analgesics: clinical experience. 382 33

Intussusception of the vermiform appendix (IVA) in a 14-year-old girl is reported. The diagnosis was made preoperatively, which is rare: only five other cases have been reported. IVA can present with variable symptoms. This patient presented with episodes of recurrent severe paroxysmal pain and vomiting, each episode being separated by several uneventful weeks. The diagnosis of IVA could be made at the fourth attack of colic by the radiological visualization of a "spiral shell" filling defect at the bottom of the cecum that was reducible by intravenous injection of a spasmolytic. Laparotomy with appendectomy rescued the patient from these distressing episodes. Although IVA is an uncommon condition, one should be aware of its existence and include it in the differential diagnosis of acute abdominal syndromes. When confronted with a clinical picture of intussusception in older children or adolescents, one should especially remember this entity as a differential diagnosis with other causes of intussusception, especially tumors.
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PMID:Intussusception of the vermiform appendix: a preoperative diagnosis in an adolescent girl. 394 40

The effect of glucagon administered as a bolus (1 mg) followed by a continuous infusion (2 mg/h) for 8 h and a placebo was compared in 37 adults with urographically demonstrated ureteral calculi less than 6 mm. The bolus injection was given 20 min after start of intravenous urography, and the infusion was initiated immediately afterwards. No effect on pain relief or passage of calculi was found. Nausea and/or vomiting were recorded significantly more frequently in patients who had glucagon than in patients who had the placebo. It is concluded that glucagon is of no value in acute ureteral colic.
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PMID:Glucagon in acute ureteral colic. A randomized trial. 394 97

Upper urinary tract calculi can be difficult to diagnose and to treat. One has to be aware that there is a risk for the mother which is often not recognized in the long term. The authors describe 17 cases of pregnant women aged between 20 and 33 who were treated for calculi in the Urological Service in Poitiers. They were diagnosed at different stages of pregnancy and a few had a previous urological history. The women presented in different ways, several of them with urinary colic and 10 with urinary colic and fever. Urinary tract infection and septicaemia also occurred. Six patients passed the stones spontaneously. The rest had to be treated by some form of operation, either during the pregnancy or afterwards, including one case of a patient who had to have her kidney and ureter removed and another who had to have a kidney removed. One patient had to have an emergency caesarean section for fetal distress although she had had stone removed at the 20th week of pregnancy. It is not possible to know from this series the incidence of stones in the tract. Various theories of the formation of the stones, including the anatomical changes that occur in the urinary tract in pregnancy, are suggested and these include the hormonal theory of dilatation of the ureters as well as the mechanical theory of changes in the course of the ureters. There are also likely to be changes in the phosphocalcium metabolism. Pain in the lumbar and lower abdominal region is the most frequent symptom occurring in 90-100% of cases and urinary tract infection is common.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Pregnancy and lithiasis of the upper urinary tract. Clinical aspects and therapeutic management]. 400 92

A new ureteral loop is introduced that, in contrast to other loops, allows the kidney to be drained continuously during stone retrieval. Thus, complications caused by blockage of the ureter by the stone, such as fever and colic pain, are avoided. The basket shape of the loop provides optimum grasping of the ureteral stone.
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PMID:New self-draining basket loop for the treatment of ureteral stones. 403 68


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