Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To assess the etiologic role of C. trachomatis and other microorganisms in idiopathic epididymitis, 23 men underwent microbiologic studies, including cultures of epididymal aspirates in 16. 11 of 13 men under age 35 had C. trachomatis infection whereas 8 of 10 over age 35 had coliform urinary tract infection. Cultures of epididymal aspirates yielded C. trachomatis alone in 5 of 6 men under 35, and coliform bacteria alone in 5 of 10 over 35. These results suggests that C. trachomatis is the major cause of idiopathic epididymitis, and coliform bacteria the major cause of epididymitis in older men. Expressible urethral discharge and inguinal pain were more common in the chlamydial cases, whereas concurrent genitourinary abnormality and scrotal edema and erythema occurred more commonly in the coliform cases. The morbidity attributable to C. trachomatis is as serious as that attributable to Neisseria gonorrhoeae.
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PMID:Chlamydia trachomatis as a cause of acute "idiopathic" epididymitis. 62 87

Trichomonas vaginalis is a flagellate protozoon which in women commonly causes vaginal itching; burning, and a frothy, offensive and seropurulent yellowish discharge. Incidence of infection in women varies from 13 to 60%, and is highest during pregnancy because of excess estrogens and in women with poor hygiene or with vaginitis. In men, the incidence ranges from 9 to 37% of persons with urethral discharge. This study presents the results of the use of a single dose treatment of Trichomonas vaginitis with 2.0 gm Tinidazole. 350 women with vaginal discharge from the Gynecology Dept. of Cairo University hospitals were studied. Microscopic study of the discharge revealed T. vaginalis in 103 cases (aged 17 to 48 years). Majority of the clinical complaints (pruritus vulvae; soreness; sense of fullness in vagina and dysuria) disappeared in all cases after administration of 2.0 gm single dose of Tinidazole. Discharge; dyspareunia and soreness or pain at vulval interoitus disappeared in about 2/3 of cases; improved in about 1/4 and persisted in less than 8% (failure in these cases was attributed to other causes such as cervical erosion; bacterial infections; hormonal or other pathologic lesions in the internal genitalia). Mild gastrointestinal reaction (nausea and vomiting) were observed in 5 cases and transient urticaria in 1 case.
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PMID:Treatment of Trichomonas vaginitis with a single dose of tinidazole. 123 91

The study was designed to assess the value of information from male subjects under fertility investigation, regarding previous genital infection, in clarifying the causes of depressed sperm quality. Information was gathered using a questionnaire which was sent to 312 men who had previously attended our laboratory for semen analysis. A previous sexual transmitted disease (STD) in the male partner did not significantly influence the sperm quality or the pregnancy rate. However, a previous STD in the female was generally associated with a lower pregnancy rate. Previous episodes with urethral discharge, dysuria, pain with ejaculation or suprapubic discomfort had little relevance for the subsequent sperm quality. The results indicate that, in general, information provided by men under fertility investigation, regarding previous genital infections or symptoms, is only of limited value in elucidating the cause of impaired sperm quality.
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PMID:The value of anamnestic information regarding previous genital infection in male fertility investigation. 129 7

Physicians followed 42 1-120 month old children who had visited the outpatient clinic at the Ahmadu Bello University Teaching Hospital in Zaria, Nigeria complaining of pain or who had to strain while urinating until they determined the cause of the urinary condition. They conducted this study to examine the clinical profile of children complaining of pain or strain while urinating. 38 presented with pain and 4 with strain. Physicians could not make a definite diagnosis for 24 children. They were able to diagnose urinary tract infection (UTI) in 42.8% (18), however. The causes of the urinary condition included bacterial (nongonococcal) UTI (26.2%), gonococcal urethritis (7.1%), and schistosomiasis (9.5%). Physicians found ova of Schistosoma haematobium in the 4 children, with much blood in their urine. Of the remaining 14 children, 13 children complained of pain. 3 boys 3 years old had urethral discharge caused by Neisseria gonorrhoeae infection. The urine of 12 children in the UTI group and 2 of the 24 no definite diagnosis group had significant leucocyturia (+or= 10 white blood cells/ml). Based on the results of this study, physicians should consider any child complaining of persistent pain as having a pathology in the urinary tract since pain was present in 13 of the 14 UTI cases. As for those patients who experience discomfort during micturition, physicians should further examine those with significant leucocyturia.
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PMID:Dysuria in infancy and childhood: an analysis of 42 children presenting in the paediatrics outpatients department. 180 78

In Riyadh, Saudi Arabia, physicians took endocervical swab examples from 325 women and urethral swab samples from 85 men to determine the extent of Chlamydia trachomatis infections and to compare an enzyme immunoassay (EIA) for the detection of C. trachomatis with the standard cell culture. All the men had urethritis. The women included pregnant, postnatal, and nonpregnant women. EIA positive tests were used to indicate C. trachomatis infection. 22.4% of all men had chlamydia infection (17.2% of symptom free men, 26% of men experiencing pain when urinating and/or urethral discharge, and 75% of men with postgonococcal urethritis). 8.6% of all pregnant women had cervical C. trachomatis infection (8.5% of asymptomatic pregnant women and 16.7% of pregnant women with vaginal discharge). 11.4% of all postnatal and nonpregnant women tested positive for C. trachomatis. The rates among these women were 66.7% for those who had pelvic inflammatory disease (PID), 50% for those with a history of abortion. 50% for those with a herpetic lesion, 25% for those using oral contraceptives (OCs), 16.3% for nonpregnant women with pain during urination and/or vaginal discharge, 11.4% for those with no symptoms, 8.1% for those with infertility, 7.7% for postnatal women having pain during urination or vaginal discharge, and 4% for those using IUDs. The EIA's sensitivity rates ranged from 75% for women with infertility to 100% for symptomatic men and those with postgonococcal urethritis, symptomatic pregnant women, symptomatic postpartum women, women with PID, and women using OCs. Specificity rates were higher and ranged 92.9-100%. EIA's high sensitivity and specificity along with its rapid performance make it a valuable diagnostic test in clinics where incidence of C. trachomatis infection tends to be high, e.g., sexually transmitted disease clinics. Clinicians could also use it in low risk settings, but they should be careful when interpreting results.
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PMID:Enzyme immunoassay in the diagnosis of Chlamydia trachomatis infections in diverse patient groups. 267 Nov 55

Clinical effects of ofloxacin (OFLX) in the treatment of the patients with chlamydial urethritis was studied. OFLX was administered at a dose of 200 mg, three times daily (600 mg) for 14 days. In all of the 26 patients with chlamydial urethritis, C. trachomatis was eliminated in 7 to 14 days after the start of administration. The subjective clinical symptoms such as pain on urination and abnormal urethral feeling was disappeared in all cases within 7 days after the administration. The objective clinical symptoms, urethral discharge, polymorphonuclear leukocyte (PMNL) in urethral discharge and PMNL in first urine were improved in 94, 68, 91% respectively on 14 days after the administration. Overall clinical efficacy rate of OFLX on 7 days, 14 days and 21 days after the administration in this study was 63, 82, 91% respectively. Whereas subjective symptoms of side effects were noted in 2 patients (7.6%), any additional medical care was needed in none of them. Because of the marked improvement of clinical symptoms and the safety administration, OFLX could be the first regimen to be chosen for the treatment of the patients with chlamydial urethritis.
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PMID:[Treatment of chlamydial urethritis--studies on clinical effects of ofloxacin]. 272 17

A group of 218 men complaining of symptoms of chronic prostatitis were identified. Symptoms included pelvic and genital pain with or without voiding or ejaculation, urinary frequency and/or urgency, and often a thin watery urethral discharge. Of the group 134 (60%) were followed carefully. With nothing but stress management therapy 110 patients (86%) reported that they were "better," "much better," or "cured." Physiologically, the therapy makes sound medical sense. It is suggested that the term "stress prostatitis" is an appropriate label for this condition.
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PMID:Stress prostatitis. 320 57

From January through June 1983, 178 male patients with urethritis were investigated on the etiology and epidemiological and clinical features. By using Chlamydia trachomatis direct specimen test (Micro Trak), C. trachomatis was detected in 60 (47.2%) among 127 patients with non-gonococcal urethritis, while it was detected 8 (15.7%) among 51 patients with gonococcal urethritis. The source of infection was a non-prostitute in 30% of chlamydial urethritis, while in gonorrheal urethritis only one patient was infected from a non-prostitute. Mean incubation period of chlamydial and gonorrheal urethritis was 28.5 and 9.2 days, respectively. In chlamydial urethritis, 33.3% of patients did not complain of urination pain and 20.4% showed no urethral discharge. Symptoms of chlamydial urethritis were milder than those of gonorrheal urethritis.
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PMID:[Clinical studies of male urethritis caused by Chlamydia trachomatis]. 337 22

Physicians treated a 37 year old man, who 5 years earlier had a successful vasectomy reversal, with a 24 hour history of intense left testicular pain, rigors, and pain and difficulty in urinating. Prior to these symptoms, he noted a mild, transient urethral discharge. Upon examination, physicians noted a fever of 38.5 degrees Celsius and swelling and tenderness around the left testis extending towards the groin. Pus cells existed in the urine, but no organism was found. While operating on the scrotal sac, physicians observed severe epididymitis which extended to the vasovasostomy site where a firm granuloma existed. The testis itself seemed fine. Blood cultures taken on admission revealed Haemophilus influenzae (non capsulate, biotype II) and ampicillin was administered intravenously. This case's physicians have not heard of any previous reported severe infection of a vasovasostomy site with bacteremia. Generally, granuloma formation after a vasovasostomy is caused by sperm leakage and represents an inflammatory response often resulting in obstruction. This may predispose the site to infection. Haemophilus influenzae rarely causes epididymo-vasitis but perhaps non capsulated strains possess an increased ability to evade host defenses, especially in a vasovasostomy granuloma, a damaged tissue.
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PMID:Epididymo-vasitis associated with previous reversal of sterilisation. 340 94

In a randomized trial, the Bardex Urinary Drainage System was tested against a routine system consisting of a silicone-coated 16F Latex Foley catheter and exchangeable 1 500 ml collecting bags. The Bardex system consists of an all-silicone balloon catheter preconnected and sealed to the drainage tube with tape. The tube is united with a 2,000 ml collecting bag via a vented drip chamber. It has an extremely hydrophilic coating (BN-74) resembling the natural glycosaminoglycans lining the urothelium. This coating is intended to minimize urethral irritation and bacterial migration and also to cause slow release of water-soluble antiseptics applied to the surface. In the present study, isobetadine 10% was applied prior to the insertion and reapplied daily after pulling gently on the catheter. Forty female patients aged 31 to 85 years completed the study. In the Bardex group of patients, bacteriuria developed in none by the third day of catheterization and in 5% by the fourth day. In the Foley group, the bacteriuria rate was significantly higher, with 35% on the third day (p less than 0.01) and 45% on the fourth day (p less than 0.02). No difference between the two drainage systems was found concerning incontinence beside the catheter, urethral pain or burning, meatal reddishness or urethral discharge. No conclusion regarding the advantages or disadvantages of the BN-74 coating and the isobetadine application can be drawn from the present study.
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PMID:Catheter-associated bacteriuria. A controlled trial with the Bardex Urinary Drainage System. 352 3


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