Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A young girl with early-onset pauciarticular juvenile rheumatoid arthritis suffered from recurrent severe bilateral iridocyclitis. Despite intensive medical therapy, she gradually lost all useful vision and ultimately required bilateral enucleation at the age of 10 years for control of pain and photophobia. Histopathologic study of the eyes revealed in the iris and ciliary body a dense inflammatory infiltrate composed principally of plasma cells, as well as angle closure, a dense cyclitic membrane, retinal detachment, cystoid macula, and optic atrophy. Immunoperoxidase stains showed little immunoglobulin within or around the plasma cells within the ciliary body, although strong reactions for IgG and kappa- and lambda-light chains were seen in other parts of the eyes.
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PMID:Early-onset pauciarticular juvenile rheumatoid arthritis. A histopathologic study. 634 50

We treated four patients with corneal burns resulting from mishaps while using electric curling irons. In all cases, the burns were symptomatic with blurred vision, tearing, pain, and photophobia. Injury was limited to the corneal epithelium, and management included debridement, topical antibiotics, cycloplegia, and pressure patching. Burns resolved completely within 48 hours after debridement and patching.
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PMID:Contact thermal burns of the cornea from electric curling irons. 647 57

A patient with refractory acute myelogenous leukemia was treated with high-dose cytosine arabinoside (3.0 g/m2 every 12 hours). Following ten doses over five days the patient developed excessive tearing, photophobia, burning ocular pain, and blurred vision. Ophthalmologic examination revealed conjunctival injection, central punctate corneal opacities with subepithelial granular deposits, and decreased visual acuity. Symptoms gradually resolved over the following four days; however, impaired visual acuity persisted for two weeks and corneal opacification did not disappear until four weeks following therapy. Prior and subsequent administration of cytosine arabinoside according to the same dose schedule for only four doses over two days and eight doses over four days were well tolerated and did not produce ocular toxicity. It is suggested that ocular toxicity results from inhibition of corneal epithelial DNA synthesis and is related to both drug dosage and duration of drug exposure. Strategies should be explored to eliminate this treatment-limiting adverse effect of potentially effective therapy.
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PMID:Ocular toxicity from high-dose cytosine arabinoside. 657 99

The ability to differentiate the various causes of ocular hyperemia is important in primary care. Symptoms such as pain, photophobia, and significant blurring of vision usually signify a more serious ocular condition or even a serious systemic disease. The majority of cases can be managed by the primary care physician, but the more serious causes of a red eye deserve prompt recognition and referral to an ophthalmologist to ensure appropriate management.
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PMID:The red eye. Why it happens, what to do, when to refer. 668 86

Eleven patients with leukemia refractory to conventional therapy were treated with high doses of cytarabine (3 g/m2 intravenously every 12 hours for six days) followed by daunorubicin (30 mg/m2/day intravenously for three days). Each patient received, in a double-masked, randomized manner, either 1% prednisolone phosphate or placebo eyedrops in each eye 12 hours before and along with the cytarabine so that we could determine whether a topical corticosteroid prevents corneal toxicity from systemic cytarabine. Ten of the 11 patients had a significant reduction in the intensity and duration of the symptoms and signs of corneal toxicity in the corticosteroid-treated eye (P less than .0005). In the placebo-treated eye, pain, photophobia, and tearing occurred at a median time of 6.5 days after initiation of therapy but resolved in approximately one week. Patients receiving high doses of intravenously administered cytarabine should receive topical corticosteroid prophylaxis to reduce the corneal toxicity associated with this treatment.
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PMID:Topical corticosteroid therapy for corneal toxicity from systemically administered cytarabine. 675 55

Three patients with leukemia developed corneal toxicity while receiving high doses (3 g/m2) of systemic cytarabine. Symptoms began five to seven days after initiation of treatment with high doses of systemic cytarabine and consisted of ocular pain, tearing, foreign-body sensation, photophobia, and blurred vision. All three patients developed bilateral conjunctival hyperemia and fine corneal epithelial opacities and refractile microcysts that were more numerous in the central than in the peripheral cornea. The symptoms disappeared without treatment in approximately one week. The corneal changes we observed with high doses of systemic cytarabine resembled descriptions of corneal toxicity from topical cytarabine and were probably secondary to inhibition of DNA synthesis in the corneal epithelium.
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PMID:Corneal toxicity with systemic cytarabine. 693 30

Autosomal dominant hereditary lattice-type corneal dystrophy is a purely corneal hereditary metabolic disturbance, i.e. a localized amyloidosis. The author describes the findings in a family presenting with this disease. The condition progresses slowly; three stages may be distinguished, namely stage A, characterized by paracentrally arranged reticular lattice lines; stage B, characterized by paracentral lattice lines and patchy central subepithelial opacifications, and stage C, distinguished by paracentral lattice lines and diffuse white central subepithelial opacifications. Frequently, lattice-type corneal dystrophy is accompanied by symptoms of a pseudo-inflammation, e.g., photophobia, epiphora, "red eye" and pain due to recurrent corneal erosions. With regard to penetrating keratoplasty, changes of the donor cornea after a certain period of latency may be observed lattice-type corneal dystrophy as a result of which three types of opacifications may occur: 1) peripheral lattice lines and spots in the stroma; 2) diffuse whitish subepithelial opacifications, and 3) recurrent straited eruptions of the corneal epithelium.
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PMID:[Clinical appearance of corneal lattice-type dystrophy (author's transl)]. 700 16

A patient underwent a radial keratotomy (RK) to reduce residual astigmatism that occurred after a corneal transplant. The patient enjoyed immediate good vision, but later intense glare, photophobia, and pain forced him to quit work. Five months later the graft became cloudy, and superficial vascularization developed in the radial scars. An 8.5-mm penetrating keratoplasty was performed 5 1/2 months after RK. Analysis of the corneal button revealed diffuse epithelial edema, epithelial ingrowth into the incisions, an irregularly thickened epithelial basement membrane, immature hemidesmosomes, focal malapposition of Bowman's layer, marked cellularity of the stroma around the margins of the incisions, and posterior folds in Descemet's membrane. Our analysis of this specimen suggests RK may carry a risk of optical and visual aberrations by producing multiple defects in the anterior and posterior aspects of the cornea.
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PMID:Histopathology of a case of radial keratotomy. 711 77

Ewing's sarcoma, which is regarded as one of the most lethal primary bone tumors, lies in the domain of the orthopedic surgeon because it occurs most commonly in the shaft of the long bones, especially in the lower extremities. Pain, leukocytosis, fever, anemia, and an elevated erythrocyte sedimentation rate are commonly seen. We are presenting a case of Ewing's sarcoma of the left greater trochanter with metastasis to the clivus producing a bilateral 6th nerve palsy. The presence of fever, nuchal rigidity, and photophobia simulated meningitis. The rapid evolution of radiological signs will be discussed.
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PMID:Ewing's tumor metastatic to the clivus, simulating meningitis: case report. 720 59

610 sacrorodiculographic and myelographic examinations were carried out injecting at lumbar level Iopamidol at 200, 300 and 370 mg I/ml concentrations. Immediate and early complications have been noticed in 18,52% of cases, i.e. sensation of pain during contrast injection, headache, nausea, vomit, neck stiffness, photophobia, epilepsy. In sacrorodiculographic examinations, side effects especially occurred by using 370 mg I/ml concentrations; in lumbar and thoracic myelographies, incidence of complications did not statistically differ by uing 300 or 370 mg I/ml concentrations. Side effects have occurred most frequently in cervical myelographies carried out with 370 mg I/ml concentration. Analysis of complications as well as radiographic results suggest to use Iopamidol at 300 mg I/ml concentration in sacrorodiculographics, in lower thoracic myelographies and in studies of narrowed, stenosed or obstructed canals; Iopamidol at 370 mg I/ml concentration may be used in upper thoracic studies and cervical myelographies.
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PMID:[Sacroradiculo graphic and myelographic investigations with iopamidol: study of 610 examinations (author's transl)]. 734 52


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