Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 465 patients treated surgically for low back and lower extremity disability, almost 10 per cent had femoral rather than sciatic distribution of pain. The average age of patients who had a primarily femoral distribution of pain is higher by a decade than those who had a predominantly sciatic distribution of pain; the higher level of the lesion and greater incidence of apophyseal joint arthritis may be associated with the aging process. The femoral distribution of pain may lead to difficulties in differential diagnosis between a spinal origin and a hip or knee origin of the problem. Radiculopathy causing femoral pain may be the result of both disk degeneration with protrusion and apophyseal arthritis with synovitis. Neuritis of the L4 nerve root is more commonly the result of a lesion at the L4-5 nerve root foramen than centrally at the L3-4 disk level. The syndrome of low back pain with femoral neuritis is not uncommon 5 or more years after an otherwise successful L4-S1, two level spine fusion. This syndrome can result from an L3-4 disk protrusion with nerve root neuritis but may be a reflex disturbance from the posterior arch structures as evidenced by fusion mass, apophyseal joint or spinous process overgrowth and associated soft tissue inflammation.
 ...
PMID:Low back pain with femoral neuritis. 12 41

The records of 40 patients who had suffered from low back pain, and who had a marked restriction of straight leg raising (SLR) have been studied. Thirty-four of these cases had referred pain down the lower limb. They were all treated, at least in the first place, by manipulation. The response to manipulation demonstrates that, in the absence of evidence of interference with nerve root conduction, limitation of SLR is an unreliable sign of possible disc pathology. Furthermore, the immediate response to manipulation, particularly in the known disc protrusions, strongly suggests that muscle spasm plays a major role in limiting SLR. These points are discussed.
 ...
PMID:The straight leg raising test: its relevance to possible disc pathology. 12 64

Injection of irritant fluid precisely into the facet joint causes referred pain patterns indistinguishable from the pain complaints frequently associated with the "disk syndrome." Even straight leg raising and diminished reflex signs can be obliterated by precise local anesthetic injection into the facet joint. The use of radiographically localized injection of steroids and local anesthetic into the facet joint has been presented as a diagnostic-therapeutic procedure. Clinical experience with a group of 100 consecutive patients suggests that this treatment alone can achieve long-term relief in one-fifth of the patients with lumbago and sciatica and partial relief in another one-third of these patients. This information suggests that the structures related to the facet joint can be a persistent contributor to the chronic pain complaints of individuals with low back and leg pain.
 ...
PMID:The facet syndrome. 13 Feb 16

The MMPI was administered to 36 male low back pain patients at the Seattle Veterans Administration Hospital. The patients were divided into three groups of 12 each. The organic group contained patients who had an organic basis for their pain. The functional group contained patients who had no organic basis for their pain. The mixed group contained patients who had some organic basis for their pain, but one that was thought to be insufficient to account for the pain they were reporting. The mixed and functional groups differed significantly from the organic group on the Hs, Hy, Pt, Sc, Hy-O, D-O, and DOR scales. The mixed and functional groups differ significantly from each other only on the Hy-O scale. The special low back pain scales of Lb and DOR were found to have little utility when used separately. When used in conjunction, however, the scales discriminated correctly 75% of the time.
 ...
PMID:The use of the Minnesota Multiphasic Personality Inventory with low back pain patients. 13 Nov 32

Four elements of the nervous system may be involved in the production of the lumbar intervertebral disc syndrome. These are the lumbosacral nerve roots, the spinal nerves, the dorsal rami and the sinuvertebral nerves. Each nerve is associated with a particular group of pathological conditions which may irritate the nerve and produce symptoms. The anatomy of each nerve determines which particular conditions may irritate it. Moreover, one or both of two mechanisms may be involved in symptom production. The type of nerve irritated determines which mechanism is involved. In the first mechanism, low back pain and referred lower limb symptoms are produced when afferent fibres from dorsal and ventral rami are stimulated where they pass in common through spinal nerves or nerve roots. In the second mechanism, dorsal rami or sinuvertebral nerves are stimulated. This directly produces low back pain, but referred pain is produced by reflex mechanisms in the spinal cord.
 ...
PMID:The anatomy of the lumbar intervertebral disc syndrome. 13

A course of 10 daily acupuncture treatments was given to 200 patients who suffered from chronic pain syndromes of at least one year duration and the result assessed at the end of the course of treatment and after an interval of at least 2 months. Treatments were individualized using needling of body loci distally and near the site of pain, and ear acupuncture. In 38 patients suffering from chronic headaches, including 13 cases of migraine-type headache, 81% reported an improvement in their condition, but only one patient was pain free for the 2-month observation period. In 162 patients with other chronic pain problems, 99 or 61% were improved or pain free at the end of treatment; in 69 of these a worthwhile degree of improvement persisted over the observation period of 2 months. Thirteen percent of all patients did not respond to acupuncture and in 26% the response was considered as transient only. Daily treatments are not more effective than weekly or biweekly treatments. Pain in the neck and shoulder region, in the knee and low back pain responded to acupuncture with prolonged improvement in over 50% of the patients treated. Facial pain syndromes and pain in the region of the trunk were least responsive and only 3 of 11 patients with post-herpetic neuralgia reported still having less pain after 2 months. Needling of effective loci and particularly ear needling often causes an instantaneous reduction or disappearance of pain; the speed of this response can only be explained by a mechanism within the nervous system. Based on our experience acupuncture represents a useful therapeutic modality in the management of pain.
 ...
PMID:Acupuncture in chronic pain. 13 11

Low back pain may arise from degenerative changes in the posterior joints of the lumbar spine. These joints are innervated by a branch of the posterior primary ramus, which follows an anatomically constant course. Pain impulses from these joints can be interrupted by coagulating this nerve with a radiofrequency wave, the probe having been placed in the area of the nerve percutaneously. Percutaneous lumbar rhizolysis was carried out under local anesthesia on an outpatient basis in 82 patients, most of whom had multiple level rhizolysis. Rhizolysis was successful in 67% of patients with mechanical low back pain without evidence of disc herniation and nerve-root compression or psychogenic pain, who had not previously undergone an operation for relief of the pain.
 ...
PMID:Percutaneous radiofrequency lumbar rhizolysis (rhizotomy). 13 70

50 patients admitted for lumbago or sciatica are examined for their "static". Radiographs of the lumbar-pelvis-hip-joint region are taken in 2 planes with the patient standing. An oblique pelvis is a certain, a reduced angle of Leger a probable influence of lumbosciatic pain. The high-assimilation-pelvis of Gutmann produces an unfavorable prognosis.
 ...
PMID:[Faulty mechanics and spinal dysfunction. Investigations of the mechanism in patients with "lumbar syndrome" (author's transl)]. 14 May 51

Intractable low back pain in children is often due to disc space infections. The clinical presentation, diagnostic workup, and treatment of four cases are presented. Symptoms often occur well before radiographic findings are evident. The diagnosis can only be made by a high degree of suspicion and repeated X-rays. Antecedent causes, such as urinary infection or intravenous administration of narcotics were lacking in this group. Fever or a preceding febrile illness was often, but not invariably, present. Percutaneous biopsies were not usually helpful. Myelography in each instance was normal. Bed rest reduced but did not alleviate the back pain. The institution of appropriate antibiotic therapy resulted in a prompt diminution of pain.
 ...
PMID:Disc space infections in children. 14 Jul 93

This report describes a double-blind between-group comparison of Tofranil and placebo in fifty-nine patients admitted to the Joint Service Medical Rehabilitation Unit suffering from low back pain. Patients were given 25 mg of either Tofranil or placebo three times a day for four weeks. Fifteen patients were not included in the analysis, nine dropping out for non-trial related reasons, two dropping out complaining of lost libido and four not taking the tablets, or taking additional drugs. One of the patients complaining of lost libido was taking Tofranil and the other was taking placebo. Over the whole sample there was no significant benefit for Tofranil over placebo as regards physical measurements. Both Tofranil and placebo groups showed a significant improvement during the trial on straight leg raise and backward flexion. For lateral flexion the Tofranil group was significantly worse than the placebo group on entering the trial, and during the trial the Tofranil group improved to match the placebo group. The clinician's pain and stiffness assessments and the patients' pain and stiffness assessments show a significant improvement for both the Tofranil and placebo groups during the trial. However, no difference is shown between Tofranil and placebo. The psychological tests show no difference between Tofranil and placebo and only a marinal improvenmet over initial condition. Further analysis according to initial diagnosis showed nothing conclusive. Numerically, the use of Tofranil produced a marked improvement in pain and stiffness in patients with 'disc lesion only' diagnoses, whereas placebo did not produce an improvement. However, this observation was far from reaching statistical significance. Side-effects were not severe for either drug. Additional medication was rarely used.
 ...
PMID:Tofranil in the treatment of low back pain. 14 Aug 27


1 2 3 4 5 6 7 8 9 10 Next >>