Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Miller-Fisher syndrome (MFS) typically presents with ophthalmoplegia, ataxia, and areflexia. Atypical MFS additionally includes bulbar impairment, affection of the limbs, or abortive presentations. Mostly, MFS follows an infection with Campylobacter jejunii. Aspergilloma has not been reported to trigger MFS. In a 48-year-old male tiredness, tinnitus, otalgia, parietal hyperaesthesia, coughing, plugged nose, hypoacusis, globus sensation, epipharyngeal pain, dysarthria, hypogeusia, arthralgia, lid cloni, facial hypaesthesia and tooth ache consecutively developed. There were occasional lid cloni, left-sided facial hypaesthesia, reduced gag reflex, divesting soft palate, and absent tendon reflexes. CSF investigations revealed normal cell-count but increased protein. Antibodies against GM1 and GQ1b were negative. Atypical MFS was diagnosed. Otolaryngological examinations revealed chronic sinusitis maxillaris from an aspergilloma. After immunoglobulins and resectioning of the aspergilloma, neurological abnormalities disappeared within 19d. MFS may manifest as unilateral lower cranial nerve lesions without affection of the upper cranial nerves or ataxia. Atypical MFS may be triggered by parasinusoidal aspergilloma.
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PMID:Anti-GQ1b-negative Miller-Fisher syndrome with lower cranial nerve involvement from parasinusoidal aspergilloma. 1608 Nov 59

Acute diffuse otitis externa (swimmer's ear), otomycosis, exostoses, traumatic eardrum perforation, middle ear infection, and barotraumas of the inner ear are common problems in swimmers and people engaged in aqua activities. The most common ear problem in swimmers is acute diffuse otitis externa, with Pseudomonas aeruginosa being the most common pathogen. The symptoms are itching, otalgia, otorrhea, and conductive hearing loss. The treatment includes frequent cleansing of the ear canal, pain control, oral or topical medications, acidification of the ear canal, and control of predisposing factors. Swimming in polluted waters and ear-canal cleaning with cotton-tip applicators should be avoided. Exostoses are usually seen in people who swim in cold water and present with symptoms of accumulated debris, otorrhea and conductive hearing loss. The treatment for exostoses is transmeatal surgical removal of the tumors. Traumatic eardrum perforations may occur during water skiing or scuba diving and present with symptoms of hearing loss, otalgia, otorrhea, tinnitus and vertigo. Tympanoplasty might be needed if the perforations do not heal spontaneously. Patients with chronic otitis media with active drainage should avoid swimming, while patients who have undergone mastoidectomy and who have no cavity problems may swim. For children with ventilation tubes, surface swimming is safe in a clean, chlorinated swimming pool. Sudden sensorineural hearing loss and some degree of vertigo may occur after diving because of rupture of the round or oval window membrane.
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PMID:Ear problems in swimmers. 1613 12

The aim of the present research was to evaluate disk displacements (DDs) of the temporomandibular joint (TMJ) among patients referred for magnetic resonance imaging (MRI) scans, and analyze the type and prevalence of DD, gender, age, side distribution, reciprocal clicking, presence of pain, range of mouth opening movement, and dental condition. The sample comprised 113 patients, 12-78 years old (the age average was 36.4 +/- 13.5 years), 92 females and 21 males, who underwent MRI between July 2001 and December 2002. A Signa Horizon system (GE) MRI scanner was used at a magnetic field magnitude of 1.5 T with a bilateral radiofrequency surface coil (6.5 x 6.5 cm). Twenty-three (20.4%) patients were found to be normal, whereas 90 (79.7%) presented with DD. Anterior DD (61.1%) was the most common type of articular disk displacement. Males and females were equally affected (no statistically significant difference). We did not find a statistically significant association between DD and increased age. Bilateral DD (70%) was the most common DD occurrence. We found a statistically significant association between reciprocal clicking and anterior DD with reduction. We did not find a statistically significant association between DD and pain, be it articular or facial pain, otalgia or cephalgia. We found a statistically significant association between anterior DD without reduction and mouth opening limitation. With regard to oral condition, we did not find a statistically significant association between DD and loss of teeth.
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PMID:Assessment of disk displacements of the temporomandibular joint. 1622 59

In our case we present a 47-year old female patient, who had a history of one year of right-sided recurrent ear pain without any signs of ear-infections. A computer tomography (CT) imaging was carried out. At the mid-modiolar level, the axial CT-scan showed a small contrast-enhancing density in the middle ear space. She refused further investigation until the ear-pain increased and slight hearing loss was present. Again, six months later a CT-scan was performed, and the hyperdense tissue formation engaged the entire middle ear cleft of the right temporal bone. Typical of MEA, no osteolytic signs were present; the skull-base was intact, the air-cell system of the temporal bone showed no osteolysis or deficiency. In the case presented here, we show a MEA which has filled the middle ear with fluid retention in the mastoid with absent destruction of any structure clinically resulting in ear pain and slight conductive hearing loss. These lesions are contrast-enhancing on CT and on magnetic resonance imaging (MRI) have brain-like signal intensity T2-weighted images. In this case, the lesion was exenterated.
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PMID:[Middle-ear adenoma]. 1644 56

Patients referred from an otorhinolaryngologist with a chief complaint of earache or other ear symptoms are common in a temporomandibular disorders (TMD) clinic. These patients often complain of other symptoms, such as headache, facial pain, and limited mouth opening, all of which can be present in a patient suffering from a nasopharyngeal carcinoma (NPC). The aim of this case report was to describe the signs and symptoms of NPC and discuss possible causes for the misdiagnosis of NPC as TMD. The characteristics of 8 NPC patients reported in the literature whose cancer was initially misdiagnosed as TMD and those of an NPC patient with TMD-like symptoms treated at the clinic of 1 of the authors are described, and the reasons for misdiagnosis are discussed. A revision of Trotter's syndrome for the differential diagnosis of TMD is proposed. There is a need for detailed exclusion criteria to be applied prior to the assignment of a clinical diagnosis based on the Research Diagnostic Criteria for TMD.
J Orofac Pain 2006
PMID:Nasopharyngeal carcinoma mimicking a temporomandibular disorder: a case report. 1648 23

Sino-orbital aspergillosis in a 61-year-old male with uncontrolled non-insulin dependent diabetes mellitus presented with three months history of left ear pain, left side headache with mucopurulent nasal discharge and one week history of progressive swelling and pain with difficulty in opening of the left eye and sudden loss of vision. In spite of surgical debridement and medical management with amphotericin B and itraconazole his visual outcome was poor and the infection was unabated at one month follow up.
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PMID:Sino-orbital aspergillosis in a diabetic patient. 1668 69

We report a 50 year old man who presented to our clinic with a 5 year history of intermittent bilateral ear pain and underwent 2 biopsies which revealed nonspecific findings. A diagnosis of relapsing polychondritis was made based on positive serum antibodies to type II collagen and a wedge biopsy which revealed areas of cartilage necrosis and focal areas of perichondral inflammation with lymphocytes and histiocytes. He was successfully treated with a prednisone taper and mycophenolate mofetil 3 g per day (increased from the initial dose of 2 g per day). During his last clinic follow up, 17 months after beginning mycophenolate mofetil, our patient had no subjective symptoms and objectively had no inflammation or pain to palpation. He was continued on prednisone 5 mg daily and mycophenolate mofetil 3 g per day.
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PMID:Successful treatment of relapsing polychondritis with mycophenolate mofetil. 1685 56

The close proximity of the styloid process to many of the vital neurovascular structures in the neck makes it clinically significant. Abnormal elongation of the styloid process may cause compression on a number of vital vessels and nerves related to it, producing inflammatory changes that include continuous chronic pain in the pharyngeal region, radiating otalgia, phantom foreign body sensation (globus hystericus), pain in the pharyngeal region, and dysphagia. The normal length of the styloid process is usually 2.0-2.5 cm long. We report a dry human skull that showed bilateral styloid processes measuring 6.0 cm on the right side and 5.9 cm on the left side. The variation in dimension of the process and its clinical implication are discussed.
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PMID:An unusually lengthy styloid process. 1730 74

Many patients who present with otalgia have a normal otological examination, and a distant source of pain must be considered. The ear receives an extensive sensory innervation arising from six nerve roots. Many other structures in the head, neck and thorax share a common neuronal pathway with the ear, and these tissues represent the possible sites of disease in the cases of referred otalgia. Consequently, the differential diagnosis is extensive and varied. Making an accurate diagnosis relies on an understanding of the complex distribution of nerve fibres and a structured approach to patient assessment. This article aims to classify the aetiology of referred otalgia and to outline current treatments for these conditions. The origins of referred otalgia may be as remote as the cranial cavity and thorax; however, dental disease, tonsillitis, temporomandibular joint disorders and cervical spine pathology represent the most frequent causes. Ear pain may also be the first sign of a head and neck malignancy. Patients complaining of otalgia, with risk factors for an aerodigestive neoplasm, and a normal ENT examination require an urgent otolaryngological opinion.
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PMID:Referred otalgia: a structured approach to diagnosis and treatment. 1750 63

The present zootherapeutic study describes the traditional knowledge related to the use of different animals and animal-derived products as medicines by the Saharia tribe reside in the Shahabad and Kishanganj Panchayat Samiti's of Baran district of Rajasthan, India. A field survey was conducted from April to June 2006 by performing interview through structured questionnaire with 21 selected respondents, who provided information regarding use of animals and their products in folk medicine. A total of 15 animal species were recorded and they are used for different ethnomedical purposes, including cough, asthma, tuberculosis, paralysis, earache, herpes, weakness, muscular pain etc. The zootherapeutic knowledge was mostly based on domestic animals, but some protected species like the peacock (Pavo cristatus,), hard shelled turtle (Kachuga tentoria), sambhar (Cervus unicolor) were also mentioned as medicinal resources. We would suggest that this kind of neglected traditional knowledge should be included into the strategies of conservation and management of faunistic resources. Further studies are required for experimental validation to confirm the presence of bioactive compounds in these traditional remedies and also to emphasize more sustainable use of these resources.
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PMID:Traditional knowledge on zootherapeutic uses by the Saharia tribe of Rajasthan, India. 1754 81


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