Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Complete ulnar collateral ligament tears incurred during the period fall 1977 through spring 1979 were treated under regional anesthesia by a single group of surgeons in an identical fashion as outpatients. Of 123 thumbs repaired, 69 (59%) were available for follow-up examination. There were 34 women and 35 men with an average age of 34.5 years (range, 16-61 years). The follow-up period averaged 31.6 months (range, 16-46 months). Weakness of pinch was described as none or mild in 66 (96%) and significant in only three (4%). Stiffness was described as none or mild in 66 (96%), moderate in two (3%), and severe in one (1%). Pain was described as none or mild in 68 (99%) and moderate in one (1%). Sixty-two patients (90%) preferred outpatient surgery with regional anesthesia whereas only seven (10%) did not. Forty-five (65%) of the 69 patients who required surgery had used traditional poles with straps, suggesting the pole as the causative factor. However, only 20% of noninjured skiers during the 1981-1982 season were using traditional poles with straps, and the total number of complete ulnar collateral ligament repairs did not decrease with the same number of skiers. Therefore, the change in pole design has not decreased the incidence of total ulnar collateral ligament tears. The results of acute surgical repair as an outpatient with regional anesthesia are excellent; 96% of the patients were pleased with the results. If the lesion is overlooked, the results of secondary construction are not nearly as good.
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PMID:Acute surgical repair of the skier's thumb. 381 59

Acquired immune deficiency syndrome (AIDS)-related Kaposi's sarcoma (KS) is more virulent than previously reported cases of KS and affects a much younger population. The cell of origin is lymphatic endothelium, with the histopathology characterized by a proliferation of small vessels with abnormal endothelial cells, extravasated erythrocytes, and spindle-shaped-cell infiltration. Clinical manifestations are pigmented, nodular lesions affecting the skin, mucous membranes, lymph nodes, and/or visceral organs. The head and oral cavity, uncommon sites in other KS populations, are frequently involved. Pain is not an early part of the clinical picture. AIDS-related KS is often widespread and rapidly progressive. However, the cause of death in most cases is attributed to opportunistic infection, which is believed to increase as a result of conventional cytotoxic chemotherapy. Recombinant interferon alpha has been the most thoroughly tested of immune-stimulating or nonimmunosuppressive drugs for the treatment of AIDS-related KS. An objective antineoplastic response rate (25% to 60%) comparable to single-agent chemotherapy with vinblastine or VP-16 has been demonstrated in several trials. Response rates to interferon alpha may be enhanced by such factors as absence of lymphoma-like B symptoms, low levels of circulating acid-labile interferon alpha, and absent history of recent serious infection. Varied drug dose, schedule, and route of administration have been employed; doses equal to or greater than 30 million U/day administered intravenously or intramuscularly appear to give the best results. Daily dosing regimens may induce tolerance for subjective toxicities (eg, fever, asthenia, and anorexia), which are often dose limiting. Direct immune stimulation following treatment with interferon alpha has not been conclusively established, but evidence suggests that respondents have low rates of opportunistic infection. Other recent studies demonstrate interferon alpha inhibiting activity against the AIDS-associated retrovirus in vitro and trials in vivo are in progress to define the clinical relevance of this observation.
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PMID:Recombinant interferon alpha in the treatment of acquired immune deficiency syndrome-related Kaposi's sarcoma. 390 16

A retrospective study was done to determine why a meat packing plant in Illinois had such an unusually high incidence of carpal tunnel syndrome. In the past 12 years, 14.8% of employees at this plant have had a carpal tunnel release. Only two of 117 patients remained unimproved at an average follow-up of 37.4 months. The most consistent result after release was relief of the paroxysmal attacks of burning pain and paresthesia. Weakness of grip was the most significant postoperative complaint in 78%. Highly repetitive motions involving extreme wrist positions, especially flexion and ulnar deviation while grasping, are predominant in meat cutting and probably contribute to the development of carpal tunnel syndrome in this industry. Previous reports of industrial carpal tunnel syndrome have not approached the incidence identified in this study. Patient awareness and Workers' Compensation benefits may account for the high numbers seeking treatment.
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PMID:An industrial cause of carpal tunnel syndrome. 395 51

Brachial neuritis is an unusual syndrome of unknown etiology that can be confused with other causes of pain or weakness, or both, of the shoulder and arm. It is important to distinguish this disorder because of its dramatic symptoms and relatively good prognosis. Sharp pain, usually in the elbow or shoulder, marks the onset of brachial neuritis, but is relatively short-lived. Weakness generally occurs as the pain is subsiding and most frequently involves the deltoid, spinati, serratus anterior, biceps, and triceps. Paresthesias, atrophy, and sensory loss are inconstant features. Electromyographic findings of fibrillation potentials and positive waves characteristically are found in a pattern indicating combined nerve-root and peripheral nerve involvement. Electromyography more frequently than clinical examination shows that the lesion is bilateral, and also is of both diagnostic and prognostic value. Other laboratory studies serve only to exclude other causes of shoulder pain. The clinical course is variable, but in 90 per cent of patients complete recovery occurs within three years. Recurrences are uncommon.
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PMID:Brachial neuritis. 401 36

An unstable carpometacarpal joint of the thumb may present with pain and interfere significantly with normal function. Weakness of the intermetacarpal ligament may result in partial or complete dislocation. A procedure that reinforces this ligament more accurately than those previously published is described. A sling is made by routing part of the extensor carpi radialis longus tendon through the interspace between the second and third metacarpals and around the base of the first metacarpal. The ligament returns to its point of entry where it is sutured to itself. The entire ligament is situated deep to the adductor pollicis longus and restores stability without interfering with the first metacarpal excursion. All 10 patients who had this procedure had full metacarpal excursion and could oppose to the base of the small finger.
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PMID:The extensor sling procedure for an unstable carpometacarpal joint. 404 40

A total of 103 patients with Addison's disease were examined. The task was to determine the information content of the clinical symptoms of Addison's disease in their interrelationship. The theorem of the multiplication of probability of independent events and probability of the appearance of at least one event were used. On the basis of the above mathematical method it has been established that the most informative syndromes of Addison's disease are the combination of asthenia and adynamia with mass deficiency, arterial hypotension, skin pigmentation and nervous-psychic break-down. In comparing clinical and mathematical results it has been shown that a simultaneous appearance of the signs of the dyspeptic syndrome, its combinations with the pain abdominal syndrome and mass deficiency point out to a possibility of the Addisonian crisis or the onset of its development. At least one of three signs of muscular or articular involvement is predicted in each patient with Addison's disease. A table given in the paper makes it possible to determine the information content of numerous complexes of symptoms of Addison's disease.
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PMID:[Evaluation of clinical symptoms of Addison's disease]. 404 91

A clinical and electrophysiological followup study was done on 23 patients with ulnar neuritis treated by surgical transposition of the nerve at the elbow. Pain was relieved in all those affected and other sensory symptoms showed some degree of improvement in most. Weakness tended to persist, but recovery of full use of the hand followed operation in 74%. Muscle wasting was the least likely to improve. The chance of recovery after operation was greatly reduced in patients in whom preoperative symptoms had been present for more than one year.
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PMID:Results of anterior transposition of the ulnar nerve for ulnar neuritis. 541 1

Nine patients are described with unilateral wasting of the hand muscles associated with elongated C7 transverse processes or with rudimentary cervical ribs. In three patients there was selective wasting of the lateral part of the thenar pad, accompanied by mild weakness of the other hand muscles. In four patients all the hand muscles were wasted, but this was more marked in the lateral part of the thenar pad than elsewhere. In two patients wasting was uniformly distributed throughout the hand. Weakness and wasting in the forearm was only present in four patients and was relatively mild. Sensory loss, when present, affected mainly the inner side of the forearm. Nerve conduction studies revealed no abnormality in the distal part of the median nerve, but some patients had reduced or absent sensory action potentials when the fifth finger was stimulated. In all nine patients a sharp fibrous band was found at operation, which extended from an elongated C7 transverse process or from a rudimentary cervical rib to the region of the scalene tubercle on the first rib. The fibrous band caused angulation of the C8 and T1 roots in five patients, and of the lower trunk of the brachial plexus in three. Pathological changes were frequently visible in affected nerves at the site of angulation. Division of the fibrous band relieved pain and paraesthesiae in eight patients and arrested muscle wasting and weakness in nine patients. There was, however, only slight recovery of power in affected muscles; wasting in the hand appeared to be unchanged after periods of up to eight years.
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PMID:Wasting of the hand associated with a cervical rib or band. 547 44

A single dose treatment trial with: spectinomycine 2 g, ampicilline + probenecide 3.5 g + 1 g, thiamphenicol 2.5 g, minocycline 300 mg was undertaken. Three teams were involved, epidemiologists clinicians, microbiologists, 636 patients were included, 483 resumed for control. A negative culture on the third day was considered a success. Failure rates were: spectinomycine 4%, ampicilline-probenecide 3%, thiamphenicol 4%, minocycline 3%. No significant difference was noted between the four rates. The delay of clinical cure was 1.98 days for spectinomycin, 1.87 days for ampicilline - probenecide, 2.16 days for thiamphenicol and 2.12 for minocycline without significant difference. When side effects were analysed, 10% of the patients reported asthenia without difference between the four treatments. Thiamphenicol is responsible for diarrhea 28%, P less than 0,01 minocycline more significantly responsible for guidiness 13%, P less than 0,001, and 18% treated by spectinomycine complained of pain at the time of injection. The antibiotics MIC's are studied. After the analysis of the results, the cost, and the resistances, one treatment was selected.
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PMID:[Results of a comparative therapeutic trial of single-dose treatment of non-complicated acute male gonorrhea]. 622 84

The effects of tiapride were studied in 180 patients, including 165 with cephalalgia originating in various causes and 15 with other types of pain. 110 of the 165 patients with cephalalgia completed the study; results were good or excellent in 78 (71%), with no differences related the the cause of the headache. 13 of the 15 patients with other types of pain completed the study, with good or excellent results in 10. Tiapride was given in a daily dose of three tablets a day in outpatients, and two daily intramuscular injections in hospitalized patients. Tolerance was excellent in 109 of the 123 patients (88%). Recorded side-effects were drowsiness in 4 patients, asthenia in 3, ebrious manifestations in 3, amenorrhea-galactorrhea in 2 and constipation in 2.
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PMID:[Effect of tiapride on headache and various other types of pain]. 629 72


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