Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The accessory soleus muscle is infrequently found; no reports of it are available in South American literature. It is found between the tibia and the soleus muscle in the distal leg. It may be misdiagnosed as a hemangioma, lipoma or sarcoma. It may be the cause of functional disorder such as varus or equino-varus. Among 254 dissections performed in young adults of both sexes and different ethnic origin we found only 2 accessory soleus muscles, both in males. One originated from the soleus muscle and was inserted in the superior aspect of the "calcaneo", in front of the "tendon calcaneo". The other originated from the anterior fascia of the soleus muscle and was inserted on the medial aspect of the "calcaneo". The clinical significance of the accessory soleus muscle is related to the presence of pain or functional disorders.
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PMID:[The accessory soleus muscle: 2 cases]. 251 18

Two cases of an unusual association between bone infarction and sarcomatous change are reported. The exact incidence of sarcomatous change in bone infarction is unknown. It seems that the risk is greatest in large medullary infarcts of bones. Also, once sarcoma has developed the prognosis is poor. Patients should therefore be advised to report any pain or swelling in an area of known medullary infarction.
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PMID:Sarcoma associated with bone infarction. A report of 2 cases. 253 31

The authors report a synovial sarcoma of the hand with an unusual case history and a favorable outcome after two years. A forty-four-year old woman suffering from uncharacteristic pain in the right hand with slightly abnormal EMG-findings for the median nerve was treated by operative release of the carpal tunnel. No unusual findings were discovered intraoperatively. The patient continued suffering from disabling pain for another year so that a second operation was performed by another surgeon. He discovered a tumor behind the median nerve which could not be removed radically because of profuse bleeding. In spite of diagnosing a sarcoma, the patient refused further surgery, however combined radio- and chemotherapy was administered for one year. The tumor was reduced in size but did not disappear. Following open biopsy and proved presence of sarcoma, the remaining tumor was removed by amputating the ulnar part of the hand. Two years following this last operation, the patient is free of local symptoms and there is no evidence of metastases.
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PMID:[Unusual course of malignant synovioma of the flexor tendon sheath of the hand]. 254 38

We have documented functional and psychosocial changes in patients with extremity soft tissue sarcomas who have undergone multimodality limb-sparing treatments. In 88 patients, parameters related to economic status, sexual activity, pain, limb function, and global quality of life (QOL) were recorded prior to surgery and every 6 months postoperatively. Changes from the preoperative assessment for every parameter were analyzed in each patient. Six months after surgery, there was a decrease in employment status, sexual activity, and in limb function in a significant number of patients. At 12 months, these decreases were still evident. Despite these changes, global QOL measured by a standardized test showed at least some improvement in a significant proportion of patients at 12 months. These findings highlight the difficulty in defining QOL. It could not be ascertained if radiation therapy and/or chemotherapy were causative factors in specific changes because of the small numbers of patients in each subgroup. However, among 60 patients with high-grade sarcomas, significant wound problems developed in 10 of 33 who received postoperative radiation therapy in combination with adjuvant doxorubicin and cyclophosphamide chemotherapy compared with one of 27 patients who received adjuvant chemotherapy alone (P = .016). Also, among high-grade sarcoma patients with 12-month follow-up, six of 19 patients who received radiation therapy and chemotherapy developed joint contractures compared with zero of 15 patients who received chemotherapy alone (P less than .04). The combination of postoperative radiation therapy and chemotherapy appeared to be associated with significantly more tissue-related injury in patients with high-grade sarcomas compared with chemotherapy alone.
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PMID:Functional and psychosocial effects of multimodality limb-sparing therapy in patients with soft tissue sarcomas. 267 Dec 82

We report an asynchronous bilateral malignant lymphoma of the breast, in a 56-year-old woman, presenting unusual clinical signs and histological features. The patient, who had a family history of breast cancer, had undergone a standard right radical mastectomy four years previously for a non-epithelial malignant tumor. At that time, the tumor was thought to be a stromal sarcoma, because some of the neoplastic cells were elongated or vacuolated. The patient recently became aware of a rapidly growing tumor of the left nipple without erosion or pain. This tumor underwent biopsy, and the histological examination showed a non-Hodgkin's lymphoma of diffuse mixed type. Staging procedures demonstrated no sign of generalized disease. Following a modified left radical mastectomy for optimal local control and accurate staging, adjuvant chemotherapy consisting of vincristine, cyclophosphamide, prednisolone and doxorubicin was initiated. Immunohistochemical staining for PAN-B and leucocyte common antigen revealed both tumors to be malignant lymphomas of B-cell type, and the first lymphoma of the right breast was thought to be showing 'signet ring' cell change. Since the two tumors were morphologically quite different from each other, it was suggested that they were asynchronous bilateral primary malignant lymphomas; however, the possibility remains that the recent left breast tumor is a recurrence of the malignant lymphoma of the right breast. The patient is currently disease-free, 10 months after surgery.
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PMID:A rare case of asynchronous bilateral B-cell lymphoma of the breast. 269 33

We studied hyperthermia for malignant tumors of the extremities, and obtained the following findings. In osteosarcoma cultured cells from OST (Human) and Dunn (Mouse), proliferation was clearly inhibited on being heated to 42 approximately 43 degrees C. On heat-treating the femurs of pigs, a rise in temperature to 42.5 degrees C or above was observed so that an antitumor effect could be anticipated. Moreover, no abnormal rise in temperature in the tissues surrounding the bone and light microscopy revealed no particular abnormalities. Clinically, a rise in temperature above 42.5 degrees C was observed in the majority of the malignant bone tumors (4 cases of osteosarcoma and 1 case of chordoma) and soft tissue tumors (1 case of epithelioid sarcoma, malignant fibrous histiocytoma, rhabdomyosarcoma, malignant melanoma and osteosarcoma) of which 2 cases were metastatic tumors. Before administration, 7 patients complained of pain, 4 of whom (57%) experienced an alleviation following treatment. Also in 5 (50%) out of 10 cases a shrinking of the tumor was observed and especially, in the case of soft tissue tumors a tendency towards a softening of tumor texture was seen.
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PMID:[Hyperthermia in malignant tumors of the extremities--experimental heating by a radiofrequency applicator and its clinical significance]. 273 74

Paget's disease is a common bone disease which usually has little influence on the patient's mobility. Functional symptoms, such as pain, and bone deformation can be controlled partly by treatment. Cardiovascular complications are rare, except for arterial hypertension which seems to be closely related to the skeletal dystrophy. The incidence of sarcoma is difficult to evaluate, but that disease has a frightful prognosis little improved by therapeutics. Neurological manifestations are diverse and due to anatomical alterations and vascular steal syndromes. Bone fractures are frequent and sometimes herald the disease. Pagetic arthropathies may benefit from surgery after medical treatment.
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PMID:[Functional consequences and complications of Paget's disease]. 273 77

Two cases of fibrous dysplasia of the skull are reported. Both patients were young women with acromegaly and were treated with radiotherapy. Progressive pareses of cranial nerves, pain, and a malignant course of the disease were characteristic in both patients, and the diagnosis of osteogenous sarcoma proved in one of them by histological examination. The clinical picture of fibrous dysplasia of the skull and the role of radiotherapy with the risk of development of malignancy is discussed.
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PMID:Fibrous dysplasia of the skull with acromegaly and sarcomatous transformation. Two cases with a review of the literature. 275 54

Elastofibroma dorsi was diagnosed in seven patients at the Columbia-Presbyterian Medical Center between 1976 and 1986. The ages of the patients ranged from 6 to 79 years (mean 49.3 years). No sex predominance was seen. Five cases of unilateral subscapular tumor and two cases of bilateral masses were identified. Four patients had pain with arm motion, and the remaining patients were free of symptoms. A nonencapsulated soft tissue mass elevating the scapula was identified by computed tomography. Incisional biopsy was performed in all cases, followed by local excision of the tumor. On gross examination, these lesions were firm and rubbery. Histologic evaluation demonstrated a slightly hypercellular fibrous tissue that contained variable numbers of fragmented elastic fibers. All patients with symptomatic tumors had complete relief of their pain after the operation. No recurrences were observed. Clinically, elastofibroma may mimic sarcoma and fibromatosis (extraabdominal desmoid tumors). Whether elastofibroma is a true neoplasm or a reactive fibrous lesion that produces not only collagen, but also abnormal elastic fibers, has been the subject of controversy and remains undetermined.
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PMID:Elastofibroma dorsi: benign chest wall tumor. 275 56

The first case of stromal sarcoma of breast occurring after augmentation mammaplasty is reported. The patient is 55-year-old Japanese woman who had received injection augmentation mammaplasty 19 years earlier. Both breasts indurated soon after mammaplasty and the patient felt a severe pain in her right breast for about 6 months before seeking treatment. Stromal sarcoma of the breast was proven by a subcutaneous mastectomy, and the determined histological subclassification was a malignant fibrous histiocytoma (MFH). The patient died with tumor recurrence 14 months after her first admission. The tumor cells were found to have invaded the surrounding tissue, such as the nerves, the muscle, the lymphatic vessels, and a severe reactive inflammation, caused by the injected material, was noticed.
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PMID:[A case of stromal sarcoma of the breast occurring after augmentation mammaplasty]. 283 42


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