Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Seventy-three patients with mid-dorsal and/or unilateral chest pain seen consecutively in the rheumatology clinic by a single clinician over a three-year period were studied, after exclusion of visceral disease. The majority were young women. The pain was dull and continuous, was aggravated by coughing and sneezing and relieved by rest. There was frequently tenderness over the thoracic spine (T4-5) and an adjacent rib, and pain at extremes of thoracic spinal movement in one or two directions was invariable. Cutaneous hyperaesthesia in a radicular distribution was found in 16.4%, but there were no other neurological abnormalities. This clinical picture is probably the result of a thoracic disc prolapse, though confirmation by myelography was not thought to be ethically justified. The condition settled in most of the patients following manipulative treatment and advice on back care. No patient developed spinal cord compression. It is concluded that this is a common benign condition which deserves wider recognition.
 ...
PMID:Benign thoracic pain. 361 61

The dorsal spine is the least affected region of the spine for intervertebral disc prolapse. The majority of cases of thoracic disc prolapse affect the lower dorsal spine, probably due to the increased mobility of that region. The dorsolumbar junction (DLJ) comprises D10 to L1 together with the intervening discs. Over a period of nine years, we have operated on thirty-two DLJ disc prolapses using a transpedicular approach in thirty patients. There were eight cases of D10/D11 disc prolapse, ten of D11/D12, and twelve of D12/L1 prolapse. Two patients had more than 1 level involvement. Back ache was the predominant symptom in patients with DLJ disc prolapse, seen in 92 % of cases. Presentation was in the form of conus/cauda equina syndrome with D11, D12 and L1 radiculopathy. All the patients were evaluated by MRI. Disc prolapse was eccentric in 10 and diffuse central in 22 levels. There was a distinct neurological improvement in all patients after surgery, pain relief being the most prominent feature. The dorsolumbar region differs from the dorsal spine in terms of mobility, anatomic and biomechanical features. It is a transition zone between the relatively fixed dorsal spine and the mobile lumbar region. These differences account for the higher incidence of disc prolapse in the region as compared to the dorsal spine cranial to D10. The transpedicular approach appears to be most suitable for discectomy for DLJ disc prolapse. The approach is minimally invasive considering the size of the incision, minimal bone removal and avoidance of vital structures. Postoperative pain is minimal and ambulation can be begun within 24 hours of surgery.
 ...
PMID:Transpedicular surgery for dorsolumbar junction disc prolapse: anatomic and biomechanical considerations of a minimally invasive approach. 1632 Jan 89

A 52-year-old woman was admitted to our emergency department with a suspected diagnosis of a thoracic disc prolapse. She presented with acute thoracic and vertebral pain of sudden onset that increased on movement and change of body position. An emergency echocardiography that was performed at the bedside showed aortic insufficiency, dilation of the aortic root, and membrane dissection in the ascending aorta. A thoracic contrast-enhanced CT angiogram verified acute aortic dissection Stanford type A, which resulted in immediate referral to the department of cardiothoracic surgery for an emergency replacement of the ascending aorta. In the emergency department, emergency bedside echocardiography facilitates the rapid evaluation of potential differential diagnoses in patients presenting with acute thoracic pain.
 ...
PMID:[Value of emergency echocardiography using the example of acute aortic dissection]. 2483 57

Fifteen patients with thoracic disc prolapse were treated at our institution over a 23 year period. The clinical presentation, investigations, surgical treatment and results of these cases are analysed retrospectively in this report. Lower dorsal region disc prolapse formed the majority of cases. Local and radicular pain, motor weakness, bladder and bowel involvement were the principal presenting features. Five cases had acute presentation while the rest had chronic and progressive symptomatology. All cases were treated by posterior decompressive laminectomy operation and in five discoidectomy was performed. It was observed on long term follow up than patients who underwent discoidectomy faired better than those in whom only laminectomy was performed.
 ...
PMID:Thoracic disk prolapse. 2954 11