Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Since 1972, 18 patients suffering from metastatic cancer in the cervical spine were treated with prosthetic replacement surgery. The surgery enabled the authors to decompress the spinal cord and the nerve roots and at the same time restore stability in the affected spine. Patients suffering from severe pain and spinal cord and/or nerve root compression secondary to involvement of a single vertebral body particularly benefited from this surgery. The rates of positive recovery were as follows: 94.1% for pain relief, 91.7% for motor recovery, and 87.5% for ambulation. The surgical efficacy was maintained until the terminal stage. Tumor recurrence took place in five cases--two anterior, and three posterior. Anterior recurrence caused a marked instability, whereas posterior recurrence did not affect stability.
 ...
PMID:Prosthetic replacement surgery for cervical spine metastasis. 319 92

The teeth provide precise skeleto-motor influences for the stomatognathic system. This unique guidance mechanism characterizes each individual's chewing pattern. It controls the activity of jaw muscles to ensure that appropriate tooth contacts within the limits of existing tooth relationships occur at the end of each chewing cycle. This acts as a means of re-setting the neuromuscular system in anticipation of the next jaw opening movement. The absence of stable centric occlusion at the end point of each chewing cycle alters neuromuscular co-ordination and predisposes to muscle dysfunction. Tooth and jaw or craniomandibular relationships are associated with craniocervical relationships and especially tongue posture. This is also directly influenced by the need for airway maintenance as the predominant influence on tongue-muscle function. The susceptibility to pain and dysfunction is further influenced by individual stereognathic sensitivity or the variable awareness of tooth contour and tooth contacts. These special features are present within the framework of the psycho-physiological and psycho-social significance of the face and mouth, which directly bears on the individual response to and appreciation of pain and dysfunction. Tooth guidance also influences condyle-disc function. Anterior and posterior teeth provide primary and secondary lateral guidance in function, directing the jaw into centric occlusion. If this guidance tends to direct the jaw posteriorly along distal, rather than mesial tooth inclines, it restricts the antero-posterior 'function' of jaw movement at tooth contact. This predisposes to condyle-disc dysfunction and the development of internal derangements, by increasing the likelihood of the posterior thick band of the disc being displaced anteriorly and the condyle posteriorly.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Occlusion as the cause of undiagnosed pain. 329 Jan 13

A fluoroscopically guided anterior approach to celiac plexus block was developed that can be performed on the supine patient during a percutaneous biliary procedure. Unlike posterior blocks, anterior blocks can be performed at any time during the procedure and thus can be reserved for the few patients whose pain does not respond to intravenously administered narcotics. Anterior blocks were performed 18 times in 14 patients; satisfactory visceral anesthesia was achieved in ten of the 18 procedures.
 ...
PMID:Anterior approach to celiac plexus block during interventional biliary procedures. 335 75

We studied 38 patients with metastatic spinal tumors and discussed the indications and methods for surgical treatment. Metastatic spinal lesions were from carcinomas (31 cases) and sarcomas (7 cases). 20 patients underwent conventional decompressive laminectomy, 10 patients were treated by posterior decompressive laminectomy with stabilization, which included Harrington or Luque instrumentation. The remaining 8 patients were treated by anterior decompression and stabilization. Anterior decompression and stabilization (effective cases 87.5%) were better than the other procedures (effective cases of posterior decompressive laminectomy and stabilization: 70%: that of conventional laminectomy: 30%) to sustain relief of pain and reduction of paralysis. Our surgical procedures were palliative and directed at relief of pain and prevention of neurological deterioration. But our results suggested that the spinal column stabilization was worthwhile in treatment of metastatic spinal tumors.
 ...
PMID:[Indication and method for surgical treatment of metastatic spinal tumors]. 338 22

Twenty-two herniations of a thoracic disc in nineteen patients were surgically excised between 1972 and 1984. An anterior transthoracic decompression or a costotransversectomy was used for all discectomies. Pain and paraparesis were the most common symptoms preoperatively. The average length of follow-up was forty-eight months. Sixteen patients had an excellent or a good result, one had a fair result, and two had a poor result. Twelve of the fourteen patients who had had motor weakness preoperatively had varying degrees of improvement in motor function postoperatively. Pain was relieved in ten patients, reduced in eight, and unchanged in one. Anterior decompression of herniated thoracic discs yielded gratifying results, but the procedure is associated with some risk of damage to the spinal cord. It therefore requires meticulous preoperative planning and careful surgical technique.
 ...
PMID:Anterior excision of herniated thoracic discs. 340 72

Forty-two temporomandibular joints (TMJs) in 21 asymptomatic volunteers were visualized by magnetic resonance imaging (MRI). The subjects, 12 males and nine females, were between 23 and 43 years of age and had no history of TMJ pain, joint noise, limited opening, or previous treatment for TMJ disorder. A cephalometric head-holder was designed to position the TMJ in an accurate and reproducible manner and multisection parasagittal images were obtained perpendicular to the longitudinal axis of the condyle. MR images depicted anterior disc position in 32% of the asymptomatic joints (8/24 males, 5/18 females). Anterior disc position in asymptomatic subjects may be a predisposing factor to TMJ dysfunction or simply an anatomic variant whose prevalence must be considered when evaluating TMJ dysfunction.
 ...
PMID:Magnetic resonance imaging of the TMJ disc in asymptomatic volunteers. 347 21

A 47-year-old man was admitted to our clinic because of the pain of left extremities for four years. The patient developed dysesthesia, hyperpathia and spontaneous pain 2 months after the onset of cerebrovascular accident with left hemiparesis. Using Toshiba TCT-20A CT scanner and Leksell's CT-stereotaxic system, stimulation electrode (by Medtronic Co.) was implanted in the posterior limb of the internal capsule which was 25 mm lateral to the posterior commissure. Ventriculography was not necessary because the target point was directly measured from the axial CT and midsagittal reformatted CT based on 18 axial CT images (2 mm thick slices). Anterior commissure, pineal calcification, posterior commissure and Sylvian aqueduct were demonstrated on the midsagittal reformatted CT by this method. The pain was relieved by the ramped square pulse stimulation (2 V, 0.6 msec, 50 Hz) and receivor system was internalized. The patient was free from pain by 30 minutes-long stimulation four to six times a day. Precise electrode placement was possible by CT images alone using high resolution CT and CT-stereotaxic system. CT-guided stereotaxic technique seemed to have an advantages especially for the implantation of electrode in the posterior limb of the internal capsule. The reason is as follows: The target is just lateral to the posterior commissure which could be recognized easily on the midsagittal reformatted CT. The internal capsule is advantageously demonstrated on the axial CT.
 ...
PMID:[CT-guided stereotaxic implantation of a deep brain electrode for the stimulation of the internal capsule--a case report]. 351 39

The surgical results of the 63 patients with metastatic cancer of the spine, treated in Chiba University Hospital and Chiba Cancer Center in 1977-86, were analyzed. The location of the primary tumor were lung (30.2%), thyroid gland (14.3%), kidney (14.3%), breast (12.7%) and gastro-intestinal tract (9.5%). All patients had intractable pain, and 47 (76%) had neurologic deficit. 46 patients were treated with posterior procedure, 7 with anterior procedure and 10 with combined anterior and posterior procedure. Anterior and posterior stabilization using implants (instrumentation, ceramics, cement) were undertaken together with tumor resection and surgical decompression in past 10 years. In 21 patients treated with laminectomy only, 53% had pain relief, and 48% had improvement of neurologic deficit. In 42 patients treated with surgical decompression and stabilization, 78% had pain relief, and 54% had improvement of neurologic deficit. Surgical decompression should be undertaken before complete paralysis develop (degree B on Frankel classification). With multi-disciplinary treatment patients with metastatic cancer of the spine survived for a significantly longer time. In patients with neurological deficit but few visceral metastasis and in those with slow-growing tumor (thyroid cancer, breast cancer and kidney cancer) in which a survival time of longer than 6 months can be expected, operative intervention using advanced surgical technique the quality of the patient's life and let patients support themselves in ADL.
 ...
PMID:[Diagnosis and treatment of secondary spine tumors]. 359 13

One hundred sixty-nine posterior cruciate condylar knee arthroplasties were evaluated for investigation of the effect of anterior displacement on instability and interface radiolucency in total knee arthroplasty. All knees were followed for at least one year, and 37 knees were followed for at least three years. The status of the anterior cruciate ligament at surgery was first compared to the postoperative, six-month, one-year, and three-year anterior drawer sign. A correlation coefficient was computed to test for the existence of a relation between these two variables. A chi-square test for statistical significance was used to compare the overall anterior drawer results with time and the anterior drawer sign at each follow-up evaluation with pain and radiolucent zones between cement and bone. For further evaluation of the effect of anterior stability on radiolucent zones, the authors analyzed the records of all their posterior cruciate condylar total knee arthroplasties over a seven-year period (average follow-up period, 2.5 years). Anterior stability over time was independent of the status of the anterior cruciate at surgery, and the presence or absence of an anterior cruciate ligament at surgery did not affect anterior stability over time. Furthermore, cutting of the anterior cruciate did not change anterior stability over time. Anterior instability proved to be statistically less at six months than at surgery and did not become worse with time. Neither anterior instability nor the preoperative state of the anterior cruciate ligament affects pain and interface radiolucency between cement and bone.
 ...
PMID:Anterior displacement. Its effects on instability and radiolucency in total knee replacements. 372 Jan 33

The indications and techniques for internal fixation of the lumbar spine in degenerative conditions have changed drastically since internal fixation was first applied to the spine almost 100 years ago. Anterior instrumentation and fusion may be used for repair of pseudarthrosis after posterolateral fusion; symptomatic lumbar scoliosis associated with degenerative disc disease; late pain secondary to posttraumatic kyphosis; postlaminectomy instability; and lumbar pain secondary to thoracolumbar kyphosis. Posterior instrumentation and fusion has been performed with Luque instrumentation over 3-4 levels in cases of multilevel instability. Combined anterior and posterior instrumentation and fusion are required for lumbosacral fusion in lumbar scoliosis with degenerative disease, and surgical correction of postsurgical lumbar kyphosis (flat-back syndrome). The techniques are demanding but with attention to detail can be performed with acceptably low-complication rates.
 ...
PMID:Techniques of internal fixation for degenerative conditions of the lumbar spine. 395 84


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>