Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0030193 (
pain
)
261,466
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Voluntary muscle is the largest human organ system. The musculotendinous contractual unit sustains posture against gravity and actuates movement against inertia. Muscular injury can occur when soft tissues are exposed to single or recurrent episodes of biomechanical overloading. Muscular pain is often attributed to a myofascial
pain
disorder, a condition originally described by Drs Janet Travell and David Simons. Among patients seeking treatment from a variety of medical specialists, myofascial
pain
has been reported to vary from 30% to 93% depending on the subspecialty practice and setting. Forty-four million Americans are estimated to have myofascial
pain
; however, controversy exists between medical specialists regarding the diagnostic criteria for myofascial
pain
disorders and their existence as a pathological entity. Muscles with activity or injury-related
pain
are usually abnormally shortened with increased tone and tension. In addition, myofascial
pain
disorders are characterised by the presence of tender, firm nodules called trigger points. Within each trigger point is a hyperirritable spot, the 'taut-band', which is composed of hypercontracted extrafusal muscle fibres. Palpation of this spot within the trigger point provokes radiating, aching-type
pain
into localised reference zones. Research suggests that myofascial
pain
and dysfunction with characteristic trigger points and taut-bands are a spinal
reflex disorder
caused by a reverberating circuit of sustained neural activity in a specific spinal cord segment. The treatment of myofascial
pain
disorders requires that symptomatic trigger points and muscles are identified as primary or ancillary
pain
generators. Mechanical, thermal and chemical treatments, which neurophysiologically or physically denervate the neural loop of the trigger point, can result in reduced
pain
and temporary resolution of muscular overcontraction. Most experts believe that appropriate treatment should be directed at the trigger point to restore normal muscle length and proper biomechanical orientation of myofascial elements, followed by treatment that includes strengthening and stretching of the affected muscle. Chronic myofascial
pain
is usually a product of both physical and psychosocial influences that complicate convalescence.
...
PMID:Myofascial pain disorders: theory to therapy. 1472 58