Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Because preoperative cervical dilatation is advantageous, especially in nulliparous subjects, dilatation before vacuum aspiration was achieved by a single intramuscular dose of 500 mcg of 16 phenoxy delta 17,18,19,20 tetranor prostaglandin (PG) E2 methyl sulfonylamide. 80 first trimester nulliparas, aged 15-34, were pretreated 3 hours before uterine evacuation with the PG analog. None of the 80 aborted during the interval between PG injection and uterine evacuation, but 25 (31%) had some uterine bleeding. In 24 of these 25, bleeding was slight ( 10 ml), and it was moderate in the other (25-50 ml). 3 hours after PG administration, the degree of cervical dilatation ranged from 4-14 mm. 60 patients (75%) achieved adequate dilatation (8 mm or more), allowing for complete uterine evacuation without mechanical dilatation. 17 patients whose cervices had dilated 6-7 mm had slight further dilatation which was easily performed. The cervix failed to dilate beyond 4 mm in 3 subjects, and mechanical dilatation proved difficult. Uterine pain was reported by all subjects. Complications (through 4-weeks follow-up) were not evident. Side effects were those common to PG, i.e., vomiting, transient pyrexia 1 degree centigrade, and pain requiring analgesia. The time interval between PG injection and adequate cervical dilatation was short enough to avoid overnight hospitalization and seems an efficacious outpatient procedure.
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PMID:Intramuscular administration of 16 phenoxy omega 17,18,19,20 tetranor PGE2 methyl sulfonylamide for pre-operative cervical dilatation in first trimester nulliparae. 71 49

Somatovisceral reflex suggested that the somatic stimulation could affect visceral function like acupuncture which treats diseases by stimulating acupoints. The neuronal connection between somatic point and visceral organ was not clear. Uterine pain referred to the groin region has long been recognized clinically. Wesselmann, using neurogenic plasma extravasation method, showed that uterine pain was referred to the groin region through a neuronal mechanism (Wesselmann and Lai 1997). This connection could be considered through the somatovisceral reflex pathway. However, the relay center of this pathway is still not clearly identified. In the present study, bee venom was injected in the groin region to induce central Fos expression to map the sensory innervation of groin region. Pseudorabies virus (PrV), a transneuronal tracer, was injected in the uterus to identify the higher motor control of the uterus. Immunohistochemistry staining revealed the Fos expression and PrV-infected double-labeled neurons in the nucleus of solitary tract (NTS), the dorsal motor nucleus of vagus (DMX), and the paraventricular hypothalamic nucleus (PVN). These results suggest a somatoparasympathetic neuronal connection (groin-spinal dorsal horn-NTS/DMX-uterus) and a somatosympathetic neuronal connection (groin-spinal dorsal horn-NTS-PVN-uterus). These two neuronal connections could be the prerequisites to the neuronal basis of the somatovisceral reflex and also the neuronal mechanism of acupuncture.
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PMID:The Possible Neuronal Mechanism of Acupuncture: Morphological Evidence of the Neuronal Connection between Groin A-Shi Point and Uterus. 2353 81