Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Seventeen patients with primary osteoarthritis of the knee were evaluated with respect to the severity and clinical importance of pain, stiffness and physical function during the conduct of a double-blind randomized controlled trial of flurbiprofen SR versus diclofenac sodium SR using the WOMAC Osteoarthritis Index. Mean importance scores were similar for items within the same dimension as well as between items in different dimensions. In general, low levels of correlation were noted between the severity and importance of symptoms. Analysis of individual WOMAC items within a given subscale indicated that, although highly correlated, they differed from one another. Factor analysis further supported the contention that scores from items within a subscale could be summated into subscale scores. These observations are of importance in the weighting and aggregation of items within discrete dimensions and have the potential for reducing sample size requirements for clinical trials in osteoarthritis.
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PMID:Relationship between severity and clinical importance of symptoms in osteoarthritis. 191 13

Sixty-two patients with early medial compartment osteoarthritis of the knee were treated with lateral heel wedges and followed for from 7 years and 5 months to 12 years. Those who were treated with heel wedges and analgesics showed a significantly greater improvement in pain score than those treated with analgesics only, but not in the walking ability score at the second follow up. The lateral heel wedge had no effect on the progress of the radiographic changes. The lateral heel wedge is useful for patients with early medical compartment osteoarthritis provided it is used with an understanding of the indications and its limitations.
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PMID:Treatment of osteoarthritis of the knee with heel wedges. 207 Dec 78

The efficacy of treatment with a heparin-glucuronilglucosaminoglycane association for external use was tested, in a double blind design, on clinical symptomatology and consumption of analgesic drugs (FANS) in patients affected with painful osteoarthritis of the knee. In the course of a 3-week treatment, the following parameters were evaluated: a) concerning the symptoms, intensity of spontaneous pain and of pain induced by both passive mobilization of the joint and walking; b) concerning the analgesic treatment, reduction of FANS consumption (expressed as percentage of basal dose) and of intensity of side effects. In the FANS + heparin-glucoronilglucosaminoglycane-treated group, the following were found with respect to the control group: a) higher reduction of pain intensity, statistically significant as far as pain on walking is concerned and higher increase in passive mobility of the joint; b) notable reduction of FANS consumption and intensity of side effects. The possible therapeutic mechanisms are discussed on the basis of both the characteristics of the employed drugs and the pathophysiology of painful osteoarthritis of the knee.
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PMID:[Evaluation of reduction of NSAID consumption after local treatment with a heparin-heparinoid combination in patients with osteoarthritis]. 210 69

A double-blind study was carried out to compare the effectiveness and tolerability of two non-steroidal anti-inflammatory drugs, etodolac and piroxicam, in patients with osteoarthritis of the knee. Sixty-five patients with active, radiologically verified osteoarthritis were randomly assigned to receive either 300 mg etodolac twice a day (33 patients) or 20 mg piroxicam once a day (32 patients) for 8 weeks. Effectiveness was measured by changes in the patients' and physician's overall evaluations, pain intensity, and night pain, recorded on 5-point scales. Other efficacy assessments included tenderness on pressure, the degree of swelling, knee flexion, the time needed to walk 50 feet, and duration of morning stiffness. After 4 weeks of therapy, mean values for patients' and physician's global evaluations, pain intensity, and night pain were significantly improved from baseline values in both treatment groups. Improvement continued throughout the study. Significant improvement in the other efficacy assessments was seen in both treatment groups after 4 weeks of therapy. There were no significant differences between the treatment groups in any efficacy assessment at any observation. Three etodolac-treated patients and 2 piroxicam-treated patients withdrew from the study because of adverse events. The results of this study indicate that 600 mg etodolac per day is as effective as 20 mg piroxicam per day in the treatment of osteoarthritis.
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PMID:A double-blind comparison of etodolac and piroxicam in the treatment of osteoarthritis. 215 Jan 87

From a population survey of 2865 subjects, test characteristics of a number of clinical findings relating to knee osteoarthritis were calculated against the standard of radiographic diagnosis. The clinical findings included from the history were age, gender, current pain in the knee, swollen knee, pain in both hands, morning stiffness, osteoarthritis in any joint, pain or stiffness, or both, in knees or hips when rising from seated position, and pain in knees or hips while climbing stairs; and from the physical examination: Quetelet's index, Heberden's nodes, bony enlargement, palpable effusion, soft tissue swelling, limitation of knee function, pain with knee flexion, bony tenderness and, finally, the latex fixation test. Of 18 clinical variables, all but Heberden's nodes, palpable knee effusion, pain in both hands, and latex fixation test showed a significant association after adjustment for age. Neither one single variable nor a combination could predict radiographic osteoarthritis of the knee with reasonable accuracy and thus be applicable in clinical practice. The x ray film, therefore, keeps its place in the diagnosis of knee osteoarthritis in general practice as well as in epidemiological research.
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PMID:Do clinical findings associate with radiographic osteoarthritis of the knee? 224 Dec 66

The authors report a prospective study of the first 51 cementless P.C.A. unicompartmental arthroplasties performed for osteoarthritis of the knee by one surgeon. Forty-two medial prostheses in 38 patients and 9 lateral prostheses in 9 patients were reviewed at a minimum of 2 years after surgery. Patients were assessed using the HSS score. In the medial joint replacement group, 37 (88%) had an excellent or good result, 3 (7%) were fair, and 2 (5%) poor. Subjectively 37 (88%) were good, 2 (5%) were fair, and 3 (7%) had a poor result. All of the lateral joint replacements had an excellent or good result. This improvement was due to pain relief and increased functional ability; preoperative range of movement was maintained or only slightly improved. There were five unsatisfactory results, three due to technical errors (one requiring revision), one a failure of patient selection, and the last an unexplained synovitis causing persistent discomfort. The early results for the cementless PCA unicompartmental knee arthroplasty are encouraging, with a satisfactory result in 90% of patients.
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PMID:Cementless PCA unicompartmental joint arthroplasty for osteoarthritis of the knee. A prospective study of 51 cases. 235 14

The efficacy of etodolac (600 mg/day) and placebo were compared in a 4-week double-blind, parallel-group study involving 104 patients with osteoarthritis of the knee and 106 with osteoarthritis of the hip. Most patients had improvement of their symptoms during the study, but significantly more improvement was seen in the patients taking etodolac. Patients with osteoarthritis of the knee taking etodolac had significantly (p less than 0.05) more improvement than placebo-treated patients in joint swelling, weight-bearing pain, and patient's overall assessment. Patients with osteoarthritis of the hip taking etodolac had significantly (p less than 0.05) greater improvement than placebo-treated patients in hip abduction, weight-bearing pain, joint tenderness, investigator's overall assessment, and patient's overall assessment. The frequency of adverse events was not statistically different in the two treatment groups. However, significantly (p = 0.05) more etodolac-treated patients (n = 9) than placebo-treated patients (n = 2) reported indigestion. The incidence of adverse events was similar in patients aged 65 years and older to that in patients younger than 65 years. Results of laboratory evaluations indicated that etodolac therapy was associated with no more hepatic or renal enzyme abnormalities than was placebo.
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PMID:Etodolac therapy for osteoarthritis: a double-blind, placebo-controlled trial. 252 40

An open clinical trial was carried out in 57 patients with osteoarthritis of the knee, hip or spine to assess the effectiveness and tolerability of etodolac. Patients received 200 mg etodolac twice daily for a period of 2 weeks. The results of clinical and patient assessments made at baseline and at the end of the study period showed that there was significant improvement in pain at rest and on active and passive movement, local tenderness, pain on climbing stairs, joint swelling and functional status. No significant changes were seen in clinical severity of the condition or, in patients with osteoarthritis of the knee, in the degree of knee flexion. Patients judged the therapeutic results to be good or excellent more often than the investigator (75% vs 50%). Tolerability of etodolac was very good with few, generally mild side-effects and only 2 patients were withdrawn, more as a precautionary measure than of necessity.
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PMID:Efficacy and tolerability of etodolac in the treatment of osteoarthritis. 252 41

Skeletal scintigraphy and QCT were performed to determine changes of subchondral bone tissues in osteoarthritis of the knee and findings were compared with plain X-ray findings, knee pain and femoro-tibial angle. Results on blood pool study were especially related to pain. Results on delayed study using single photon emission computed tomography revealed high uptake on the medial side of the femur and tibia parallel to plain X-rays and pain. The QCT value was slightly decreased as osteoarthritic changes progressed without a significant change. In addition, delayed study in cases with previous surgical intervention by high tibial osteotomy revealed a lower uptake on the medial side of the femur and tibia. When skeletal scintigraphy accurately reflects blood flow through the subchondral bone tissues and is closely related to morbidity and pain, this modality is valuable in analysis of signs and symptoms as well as postoperative outcome.
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PMID:[Clinical application of skeletal scintigraphy and quantitative computed tomography (QCT) to osteoarthritis of the knee]. 258 27

The aim of the study was to evaluate the therapeutic effects of a Heparin-Glucuronilglucosaminoglycane association for external use in patients affected with painful osteoarthritis of the knee. The cutaneous pain threshold and subcutaneous tissue thickness at periarticular level were chosen as parameters for evaluation. In a previous experimental study, they proved to be reliable indexes of pain-related alterations of sensitivity and trophism. These parameters were measured in basal conditions and after 10, 20 and 30 days respectively of therapy consisting in 3 daily administrations of the drug. The measurements were also repeated 30 days after the interruption of the treatment. The cutaneous pain threshold and the subcutaneous tissure thickness underwent an increase and a decrease respectively in comparison with basal values in all the determinations performed. These increases and decreases were statistically significant throughout the whole period of treatment and remained significant even after the interruption of the drug administration (significant levels between p less than 0.04 and p less than 0.001). The possible mechanisms of such effects were examined, according to the pharmacological characteristics of the drug and the pathophysiology of pain and inflammation.
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PMID:[Effect of a combination of heparin-glucuronylglucosaminoglycan for topical use in modification of pain in osteoarthritis of the knee]. 264 48


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