Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Critical lower limb ischemia is a term used to define those patients with chronic ischemic pain at rest, ulcerations or limb necrosis caused by confirmed atherosclerotic lesions of the arteries. In this paper to evaluate of the clinical usefulness of silver coated prostheses in critical lower limb ischemia was presented. The use of the vascular artificial prostheses (dacron, dacron with velour, dacron albumin coated, polytetrafluoroethylene, dacron gentamicin/ryfampicin coated) in the critical ischemia limbs threatened is her contagion. In cases of potentially threatened a contagion is indicated the use of vascular prostheses about enlarged resistance on the contagion, e.g. the silver/collagen coated prosthesis. A foundation of the use of such prostheses are antibacterial proprieties of polyester fibers salts of the silver. An aim of many works is estimation of healing of the silver prostheses of grafted in lower limb at ill with the critical ischemia where infecting of the synthetic material is extremely probable. The healing of the silver prosthesis rated is most often at the use of the scintigraphy with Technetium 99. One attends that such research will make possible the estimation of the usefulness of the vascular silver prostheses in reconstructive operations in the vascular surgery, particularly in cases threatened with the infection of used synthetic material.
 ...
PMID:[The use of silver/collagen coated vascular prostheses in the treatment of critical limbs ischemia]. 1795 51

The purpose of this study was to examine the safety and efficacy of the Frontrunner XP CTO (chronic total occlusion) Catheter (Cordis) for recanalization of long femoropopliteal artery occlusions. A Frontrunner catheter was used to treat 26 CTOs in SFA after guidewire failure (68.3 +/- 8.8 years). Sixty-seven percent of patients had severe claudication. Critical lower limb ischemia with rest pain or minor tissue loss was present in three and eight patients, respectively. All the lesions were considered complex (TASC B, C, and D); 68% of the lesions were heavily calcified. The mean lesion length was 17.6 cm (range, 10-42 cm). The initial attempt to cross the occlusion with the CTO guidewire V18 was unsuccessful in 26 of 76 limbs (34.26%). A secondary attempt using the Frontrunner catheter (crossover approach, 27%; antegrade, 73%) performed in all 26 failed cases was successful in 17 limbs (65.38%), increasing the technical success rate to 88.12%. The main reasons for failure with the Frontrunner were inability to cross the lesion due to heavy calcification (six of nine) and inability to re-enter the true lumen after subintimal passage of the occluded segment (three of nine). The mean fluoroscopy time was 22.9 min. Minor complications included one distal extension of the dissection with involvement of the first popliteal segment and one perforation in the occluded segment. No major complications were seen. In conclusion, recanalization with the Frontrunner CTO catheter is a simple and safe method with a high technical success rate in the endovascular treatment of long superficial femoral artery occlusions and should be an alternative method after guidewire failure.
 ...
PMID:Percutaneous intraluminal recanalization of long, chronic superficial femoral and popliteal occlusions using the Frontrunner XP CTO device: a single-center experience. 1977

Critical lower limb ischaemia is a diffuse pathology that could cause claudication, severe ischaemic pain and tissue loss. The common treatment includes modification of risk factors, pharmacological therapy and endovascular or surgical revascularisation of the lower limb to restore a pulsatile flow distally. Spinal cord stimulator is seen as a valid alternative in patients unsuitable for revascularisation after endovascular or surgical revascularisation failure and as adjuvant therapy in the presence of a functioning bypass in patients with extensive tissue loss and gangrene presenting a slow and difficult wound healing. We report our experience on spinal cord stimulation (SCS) indication and implantation in patients with critical lower limb ischaemia, at a high-volume centre for the treatment of peripheral arterial disease.
...
PMID:Spinal cord stimulation to achieve wound healing in a primary lower limb critical ischaemia referral centre. 2471 87