Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Iselin's disease (traction apophysitis of the tuberosity of the fifth metatarsal) has been reported rarely, but is probably more common than appreciated. It appears to be more common in athletically active older children and adolescents. Four patients with this condition were treated conservatively and all had resolution or improvement of symptoms. In one, however, nonunion developed and continues to cause intermittent pain at age 20 years. Early recognition and treatment may prevent long-term complications.
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PMID:Iselin's disease. 173 1

Os vesalianum pedis is an uncommon accessory bone. It is located proximal to the fifth metatarsal and found within the peroneus brevis tendon. The incidence is very low, and as with other accessory bones of the foot, it is rarely symptomatic. When symptomatic, the main objective in diagnosis is to differentiate from an ossifying apophysis of the fifth metatarsal base, an apophysitis of the fifth metatarsal base (Iselin's disease), a fracture of the tuberosity of the fifth metatarsal, nonunion of a tuberosity fracture of the fifth metatarsal, an ununited apophysis of the fifth metatarsal base, and an os perineum. We present a very rare case of a bilateral symptomatic os vesalianum pedis. The clinical presentation and course are described, as well as its treatment. This case showed that both conservative and operative treatment can be effective for pain reduction. Operative treatment of course has the risk of complications, a lesion of a branch of the sural nerve occurring in this case. On the other hand, conservative treatment can take a long time to reduce pain, and there is always the risk of recurrence.
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PMID:Bilateral symptomatic os vesalianum pedis: a case report. 2157 Mar 23

Although Iselin's disease, apophysitis of the fifth metatarsal base, is not infrequent in clinical practice, it is accepted as a rare cause of lateral foot pain in young adolescents. Usually a simple clinical examination and radiographs are sufficient for diagnosis. We present a patient with Iselin's disease and discuss its clinical and radiographic characteristics, differential diagnosis, aetiopathogenesis and treatment.
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PMID:Traction apophysitis of the fifth metatarsal base in a child: Iselin's disease. 2483 13

Iselin's disease was first described in 1912. It is a condition affecting the tuberosity of the base of the fifth metatarsal. It has been described as a traction apophysitis predominately affecting adolescents, in particular those who partake in regular sporting activity. The condition is rarely reported and likely to remain undiagnosed, possibly mistaken for a fracture. The present report reviewed the available published data to highlight this condition as a differential diagnosis in patients with fifth metatarsal pain. Investigations, treatments and outcomes into this condition are described, to support the management and diagnosis of this condition.
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PMID:Iselin's Disease: A Systematic Review. 2884 92