Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 44-year-old man presented with painful swelling of wrists and ankles, severe pain at both tibiae, clubbing of fingers and toes and arthritis in wrist and ankle joints. The chest roentgenogram showed consolidation of the right lower lobe, whereas plain roentgenograms revealed solid periosteal reaction at both tibiae. CT and bronchoscopy confirmed the presence of adenocarcinoma of the right lower lobe. Moreover, mycobacterium of tuberculosis was isolated by culture of the patient's sputum.Our patient received antituberculous treatment and soon he underwent surgical excision of the tumour and subsequent chemotherapy. Ten months later, he returned with metastatic lesions in the brain and the adrenals. A few days later, he died.The patient suffered from bronchial adenocarcinoma as well as pulmonary tuberculosis. As a complication of these two coexisting conditions, the patient developed hypertrophic pulmonary osteoarthropathy.
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PMID:Hypertrophic pulmonary osteoarthropathy secondary to bronchial adenocarcinoma and coexisting pulmonary tuberculosis: a case report. 1884 Feb 65

Charcot neuro-osteoarthropathy (CN) is among the most devastating complications of neuropathy and now most commonly occurs in the feet of diabetic patients. Because it is relatively rare and because most patients and practitioners do not expect major bone pathology in the absence of significant pain, CN is often misdiagnosed as cellulitis, deep venous thrombosis, or gout. Also, radiographs early in the process are often relatively unremarkable. Although MRI findings are characteristic, treatment should not wait for the MRI result. The hot swollen erythematous neuropathic foot suspected to be CN should be emergently mechanically protected, usually in an irremovable total contact cast. Mechanical protection is the mainstay of conservative therapy, but surgical reconstruction of a deformed foot can usually also be successful. Unless diagnosed very early, significant decrements in quality of life result. Controlled studies are urgently needed to identify best practices.
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PMID:The Charcot foot: medical and surgical therapy. 1899 Mar

An intervention to prevent chronic back pain and muscular-skeletal disorder (MSD) was implemented in the second half of 2003 at an automobile factory targeting employees from the cable construction division who were redeployed internally to a another division of the plant. This action-research consisted of exploring the benefits of establishing specialized gym classes for back exercises and re-education at the workplace to help prevent chronic lower back pain. Employees who had previously reported lower back pain that was either slightly disabling to none incapacitating and those who were in-line to be redeployed to another division were all offered the opportunity to undertake a medical exam and physical therapy check-up and to respond to a self-administered questionnaire in order to assess the functional state of of each employee, his perception of pain, and the manifestation and impact of this in daily life. Employees were oriented to appropriate gym and physical therapy classes for re-educating and improving back strength under the supervision of a physical therapist. As a follow-up to this, in between sessions, the workers were invited to redo the assessment tests in order to assess and appraise the value of the effects of the exercises. The action-research carried out in the workplace shows a positive contribution of the gym classes specialized for back exercises and re-education training to the improvement of the status of those persons suffering from lower back pain. In addition, placing employees in new professional positions following their completion of these gym and physicals therapy sessions proves to be essential for validating the acquisition of knowledge gained and the commitment to adjusting to the job position.
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PMID:[Preventing chronic back pain at the workplace: action-research at the workplace]. 1908 83

In India, particularly in Sunderban of West Bengal, collection of prawn seeds is one of the major earning resources among prawn seed collectors. They are compelled to carry out a considerable amount of hard, manual, rigorous tasks in the river of the Sunderban area for collecting prawn seeds. They have to adopt some undesirable postures that may lead to the development of musculo skeletal disorder (MSD). The main aim of the present study is to investigate the prevalent postures adopted by the prawn seed collectors during individual prawn seed collection and to analyze the causation of discomfort feeling related with those postures. For this study, 21 male and 25 female prawn seed collectors were selected randomly and a detailed posture analysis was performed among them by means of OWAS method. It was observed that these workers worked continuously in awkward postures during certain prawn seed collection activity and consequently they suffered from discomfort feeling (pain) in different parts of the body.
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PMID:The prevalence of musculoskeletal disorders among prawn seed collectors of Sunderbans. 1922 95

A 40-year-old woman was hospitalized for investigation of dry cough, dyspnoea, and pain and swelling in the large joints of the arms and legs. Chest CT revealed a left hilar mass with partial atelectasis in the apical segment of the left lower lobe. X-ray of the wrists, elbows, ankles and knee joints showed a periosteal reaction, associated with hypertrophic pulmonary osteoarthropathy. Endobronchial biopsy suggested a pulmonary epithelioid haemangioendothelioma. Whole left lung resection was performed and the patient died of respiratory failure 1 month postoperatively.
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PMID:Pulmonary epithelioid haemangioendothelioma mimicking central lung cancer. 1934 25

Fibrous dysplasia of bone is a congenital skeletal disorder characterized by proliferation of spindle cells inside an intramedullary collagenous stroma and by formation of metaplastic bone. An aneurysmal bone cyst is a lesion of unknown etiology. Macroscopically it appears like a blood-filled cavity that expands the affected bone. Histologically, fibrous septa are bordered by macrophages, giant cells, inflammatory cells, and areas of bone production. Hemorrhagic areas can rise into fibrous dysplasia. The lesion appears as an aggressive and destructive process that is difficult to diagnose properly. A 29-year-old woman presented with a 2-year history of left inguinal and lumbar pain. She reported increased pain after physical activity. Magnetic resonance imaging of the left femur (without intravenous gadolinium) showed a mass extending 14 cm along the femoral metaphysis. This lesion involved cortical bone that was broken in the posteromedial site. Computed tomography confirmed the osteostructural lytic alteration that "blows up" the proximal femur metaphysis. A trochar biopsy allowed the diagnosis of aneurysmal bone cyst on fibrous dysplasia, excluding malignancy. The lesion was treated with curettage and local adjuvants and filled with bone grafts. Internal fixation with a sliding screw plate was also performed. Radiographs at 1 year postoperatively showed good consolidation of the grafts and absence of local recurrence. The patient achieved active and passive mobilization of the left hip with no pain.
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PMID:Secondary aneurysmal bone cyst in fibrous dysplasia of the proximal femur. 1947 53

For patients with diabetes mellitus and diabetic foot syndrome customized orthopedic shoes represent the most effective treatment to avoid foot ulceration and amputation. A total of 53 patients suffering from diabetes and treated with customized orthopedic shoes for more than 5 years were included in the study. Of the patients 91% had peripheral artery occlusion disease, polyneuropathy and diabetic neuropathic osteoarthropathy (DNOAP) and in nearly 25% amputation of one limb had already been carried out. The incidence of ulcers over a time period of 5 years was assessed from the patient records and questioning the patients. Questions on the duration of wearing orthopedic shoes, the durability of the shoes and resulting pain were also included. All patients except for one had problems walking on uneven surfaces. Of the patients 89% claimed to have used their shoes always or nearly always and 25% of the shoes had to be replaced after 1 year. The incidence of ulcers was 38% after 5 years. Treatment with customized orthopedic shoes is an effective method to prevent ulcers and amputation. To be successful it is necessary to control that the shoes are made correctly. Not all shoes last as long as 2 years.
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PMID:[Orthopedic made-to-measure shoes for diabetics. Long-term 5-year outcome]. 1992 91

Paraneoplastic osteoarthropathy includes various forms of arthritis syndrome which probably relates to immune mechanisms, and much more often hypertrophic osteoarthropathy(HOA). HOA is often accompanied with primary lung cancer, malignant pleural mesothelioma, chronic pulmonary diseases, cyanotic congenital heart diseases, among others. The presentation of HOA sometimes precedes the diagnosis of underlining malignancies, and consists of finger clubbing, polyarthralgia, and pain and swelling of forearms and lower thighs. Acute onset of the symptoms except for finger clubbing may indicate expansive growth of malignant diseases. Recently, a gene responsible for prostaglandin E2 degradation was identified as a cause of idiopathic HOA. As idiopathic HOA is clinically indistinguishable from paraneoplastic HOA, this discovery may highlight some common biomarkers involved in tumor progression and HOA formation.
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PMID:[Osteoarthropathy]. 2056 2

Bisphosphonates are widely use for pathologies such as osteoporosis, Paget's disease or bone metastasis. However, their potent antiresorptive properties open new therapeutic opportunities for other conditions associated with an increased focal or systemic bone remodelling. Moreover, apart from their antiresorptive activity, bisphosphonates could also have others properties through a specific analgesic or anti-inflammatory effect. Thus, rheumatic diseases like rheumatoid arthritis, spondylarthritis or SAPHO syndrome (acronym for synovitis, acne, pustulosis, hyperostosis and osteitis) that are associated with systemic and sometimes focal bone loss could be good candidates for bisphosphonate therapy. Other non-inflammatory rheumatic diseases like bone osteonecrosis, algodystrophy, fibrous dysplasia or neuropathic osteoarthropathy are also associated with pain and an increase of focal bone remodelling. Several studies have shown that bisphosphonate could have promising therapeutic potential in these inflammatory or non-inflammatory diseases where therapeutic options are usually few. This review will focus on the new potential alternative indications for bisphosphonate in rheumatic diseases.
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PMID:Alternative use of bisphosphonate therapy for rheumatic disease. 2072 20

A 20-year-old woman was referred to our hospital with complaints of both knees due to patellofemoral pain. Osteopathia striata, a rare radiographic skeletal disorder, manifested by fine, linear striations primarily in the long bones, was a chance finding.
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PMID:[A woman with bilateral linear striations in femur and tibia]. 2142 52


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