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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This is the first report of bilateral orbital apex syndrome caused by malignant lymphoma. A 73-year-old man suffered from right forehead pain, diplopia and right numb cheek. Thereafter progressed bilateral visual disturbance rapidly, and soon he became blind. Cavernous sinus thrombosis was suspected clinically, but histological study of the biopsied specimen from the nasopharynx revealed malignant lymphoma (non-Hodgkin, diffuse, large cell type) (LSG). The patient died 5 months after the onset of his illness. Autopsy revealed lymphoma cell invasion and necrosis in parasellar region, bilateral optic nerves, nasopharynx, and left posterior root of L3. There was no lymphoma cell in the liver, spleen, or gastrointestinal tract. The nasopharynx was suspected to be the primary site of the tumor. In bilateral orbital apex syndrome, malignant lymphoma should be taken into consideration. Remission can be expected if treatment is started in early stage.
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PMID:[Malignant lymphoma presenting with bilateral orbital apex syndrome]. 260 39

Intracranial complications of sinusitis are infrequent since the advent of antibiotics, and furthermore the prognosis is improved by medical therapy. We have seen a patient with an intracranial complication of sinus infection that had a history of frontal bone trauma five years ago. Then following an upper respiratory tract infection, headache, bilateral periorbital pain and swelling, spiking fever, neck stiffness, bilateral chemosis and ophthalmoplegy developed. Cavernous sinus thrombosis was diagnosed clinically and high doses of I.V. antibiotics were started promptly. The patient's condition improved in the first week of her admission. She was discharged three weeks later, without any surgical intervention. Two-year follow up showed no cranial nerve palsies or any neurologic deficiencies. A good result has been achieved by immediate medical measures.
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PMID:Cavernous sinus thrombosis: a rare complication of sinusitis. 905 42

Cavernous sinus thrombosis not only presents with constitutional symptoms including fever, pain and swelling but also with specific findings such as proptosis, chemosis, periorbital swelling, and cranial nerve palsies. It is known to occur secondary to the spread of paranasal sinus infections in the nose, ethmoidal and sphenoidal sinuses. However, paranasal sinus infection of dental origin is rare. The following is a case of cavernous sinus thrombosis due to the spread of an abscess in the buccal and pterygomandibular spaces via buccal mucosal laceration.
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PMID:Cavernous sinus thrombosis caused by a dental infection: a case report. 2524 50

Cavernous sinus thrombosis (CST) is a life-threatening entity with a high rate of mortality and lifelong morbidity. A strong clinical suspicion of the complication, early radiological detection and institution of timely, aggressive treatment are required to prevent permanent neurological disability. We present a 12-year-old girl with bilateral CST following unilateral pansinusitis. Clinical symptoms of headache and retro-orbital pain out of proportion to clinical signs on presentation prompted a suspicion of something beyond sinusitis and raised the clinical suspicion of cavernous sinus involvement. In spite of institution of an early medical treatment, she progressed to develop bilateral cranial nerve paresis. However, with the persistence of antibiotics and anticoagulation therapy, she was successfully managed with no residual neurological sequelae. The aim of this presentation is to highlight the grave consequences of cavernous sinus involvement following infections of paranasal sinus and the rare complete recovery from disability in this case.
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PMID:Early cavernous sinus thrombosis following unilateral pansinusitis in a child. 2591 67

Septic cerebral venous sinus thrombosis, once a common and deadly disease, has fortunately become rare now. Not only that the incidence has fallen significantly after the antibiotic era, the morbidity and mortality has also decreased substantially. Cavernous sinus thrombosis is by far the commonest form of septic cerebral venous sinus thrombosis. Due to its rare occurrence, a lot of current generation clinicians have not encountered the entity in person. Despite all the advances in diagnostic modalities, a high index of clinical suspicion remains the mainstay in prompt diagnosis and management of this potentially lethal condition. Keeping this in view, the authors have reviewed the subject including the old literature and have summarized the current approach to diagnosis and management. Septic cavernous thrombosis is a fulminant disease with dramatic presentation in most cases comprised of fever, periorbital pain and swelling, associated with systemic symptoms and signs. The preceding infection is usually in the central face or paranasal sinuses. The disease rapidly spreads to contralateral side and if remains undiagnosed and untreated can result in severe complications or even death. Prompt diagnosis using radiological imaging in suspected patient, early use of broad spectrum antibiotics, and judicial use of anticoagulation may save the life and prevent disability. Surgery is used only to treat the nidus of infection.
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PMID:Septic cerebral venous sinus thrombosis. 2694 52