Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Chronic spontaneous dislocation of the sternoclavicular joint occurs more frequently in athletes than nonathletes, causing weakness and sometimes pain during prolonged stress upon the arm. Five such joints were successfully treated in 4 patients by means of a dynamic method of repair--tenodesis of the sternal head of the sternomastoid muscle. The sternal origin of the sternomastoid muscle in continuity with its muscle belly and strip of sternal periosteum is looped under the first rib, back through a drill hole in the clavicle and sutured to itself to replace the damaged costoclavicular ligament. Dislocations of the joint should not be repaired for purely cosmetic reasons as the risk of keloid scar formation in this region is notoriously high. All the patients who were young and athletically inclined, recovered fully within 4 months of the operation and returned to their sporting activities. Follow-up has ranged from 12 to 38 months. There have been no late complications or failures of the technique.
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PMID:Chronic dislocation of the sternoclavicular joint: an operative repair. 47 70

The in situ rib split graft was devised in response to experimental data demonstrating superior survival of autograft bone bearing periosteum. A more compelling reason for adopting the technique as a standard means for obtaining limited amounts of rib graft is the marked decrease in pain and pulmonary morbidity postoperatively. This is achieved by leaving the inner half of the rib in continuity and resecting only the outer half as the graft.
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PMID:The in situ rib split graft. 54 9

There is disagreement in the literature as to whether responsivity to painful stimuli possesses psychometric correlates. A series of methodological and statistical factors are specified in this paper which could account for the equivocality of the literature. A series of experiments were performed in which (a) various methodological and statistical issues were first resolved and (b) psychometric correlates of pain perception were then identified by means of a stepwise multiple regression procedure. The criterion variable consisted of the psychophysical judgment of pain during a 2-min. exposure to a 3,000 gm. force on the periosteum of the left fore-finger's second digit. The predictor variables consisted of selected psychological states and traits measured by the State-Trait Anxiety Inventory, Somatic Perception Questionnaire, Depression Adjective Checklist, Profile of Mood States, Eysenck Personality Inventory, and the Embedded Figures Test. The test-retest reliability of the pain test ranged from .64 to .84 across trials separated by a 3-wk. period. In the first experiment significant multiple regressions ranging between .57 and .72 were observed and psychological traits (field dependence, extraversion and trait anxiety) accounted for the variance in these analyses. In the next experiment significant multiple Rs ranging from .62 to .68 were observed. This served as cross-validation for the first experiment. The major difference was that psychological states (depression and vigor) as well as traits entered the multiple regression equations for certain of the analyses. It was concluded that selected psychological states and traits are significantly correlated with the perception of pain.
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PMID:Psychometric correlates of pain perception. 70 52

A resection method for the palatal root of the maxillary molar is presented, in which the tip of the root is exposed by widening the resection opening of the buccal roots into the maxillary sinus and by lifting the periosteum from its underlying tissue above the tip of the root. The method suits cases in which the mucous membrane of the sinus is healthy and the floor of the sinus extends between the roots or the tip of the root is close to the sinus. By this method, palatal opening and damage to the mucous membrane of the sinus are avoided. Pain and discomfort are minimal. In addition, the topographic anatomy of the floor of the maxillary sinus and the dental roots and radiographic methods suitable for diagnostics are discussed.
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PMID:Transantral, subperiosteal resection of the palatal root of maxillary molars. 81 90

Some unfavourable and favourable peculiarities and principles have to be recognized in the therapy of intraarticular knee joint fractures. Apart from the self-evident necessity of an exact reconstruction of joint faces (more often than before conditioning the indication for arthrotomy) timely mobility can be reached by only adapting osteosynthesis, as in this region there is virtually no pseudoarthrosis. A defect in the articular face of the tibia can be replaced by a part of the patella. A shattered patella can be partially or totally extirpated and good function can be obtained if the extirpation prevents the remaining parts of the periosteum from developing a neopatella, limiting mobility and causing pain. The distal end of the femur can ideally be fixed with a condylar splint even in those cases where a number of fragments can only approximately be put together under the condition of knee joint face restitution. In order to restore the function, it is sometimes necessary to loosen and prolong the quadriceps tendon to achieve sufficient flexion if this is required by the living and working conditions of the injured person.
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PMID:[Principles and peculiarities of the therapy of knee joint fractures (author's transl)]. 91 39

The split thickness flap, apically replaced, with internal linear periosteal fenestration, is a combination of two known techniques. This procedure is another choice to solve mucogingival problems. The advantages in addition to securing a firmer bond of periosteum to bone and mucosa to periosteum at the selected position are: there is no bone exposed, healing is apparently faster and postoperative pain is minimal. An experimental work, carried out on dogs to study the histological reactions after this procedure, is in progress. The results of these observations will be reported in a future publication.
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PMID:Split thickness flap, apically replaced, with protected linear periosteal fenestration. 106 Jul 54

Toxic effects of excessive vitamin A and of excessive vitamin ADE were studied in 9 mixed Labrador Retriever pups. Clinical signs were loss of body weight, dullness, emaciation, roughened coat, evident pain in limb joints, and retarded growth. Radiologic changes were decreases in overall length and thickness of long bones, development of osteophytes, periosteal reaction, and premature closure of epiphyses. Pathologic changes were degenerative epiphyseal plate, hemorrhage and exostotic proliferation of periosteum, fatty liver, and microcalculi in kidney. Toxic effects of excessive vitamin A did not appear to be so great when it was administered as vitamin ADE.
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PMID:Hypervitaminosis A in the dog. 119 Jun 3

Recurrent thoracic outlet syndrome that requires reoperation accounts for 1% of first rib resections. Symptoms in a series of 30 patients were mainly neurological and consisted of pain and paresthesia involving the neck, shoulder, arm, and hand and were severe and unrelenting. Recurrence of symptoms ensued from one month to seven years following initial rib resection, with the majority appearing within the first three months. Nerve conduction velocities were diminished to an average of 51 m per second, well below the normal of 72 m per second. Reoperation was required after a period of extensive physiotherapy and muscle relaxants. The high posterior thoracoplasty approach is recommended for all reoperations, as it gives better exposure to achieve safe neurolysis of the plexus and complete excision of the regenerated periosteum and posterior rib remnant, which were present in almost all patients. Results of reoperation were gratifying, and postoperative nerve conduction velocities were improved to an everage of 66 m per second.
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PMID:Reoperation for recurrent thoracic outlet syndrome. 124 18

The aim of this study was to describe the normal distribution of calcitonin gene-related peptide (CGRP) and substance P (SP) containing fibres in the knee joint of the mouse and to obtain insight into the changes in innervation associated with degenerative processes in the joint. Arthrosis was induced by a single subpatellar intra-articular injection of bacterial collagenase. After decalcification in EDTA solutions, the CGRP and SP fibres were visualized by peroxidase-antiperoxidase pre-embedding immunocytochemistry for light microscopy. Control experiments on the mouse brain as a reference for the effect of EDTA on the immunostaining showed that the decalcification procedure with EDTA had not impaired the immunostaining. A rich innervation of thin varicose CGRP and SP immunoreactive fibres was found in most peri- and intra-articular tissue components. The periosteum, synovial tissues, the joint capsule and the intra-articular fat tissues were richly innervated. Less intense innervations were also found in the subchondral bone plates of the tibio-femoral joint and of the patella. Fibres were also found in the soft tissues between the patellar tendon and the femoral groove. No differences could be found between the location of CGRP and SP fibres with respect to the localization in the joint, but generally more CGRP fibres were found. The collagenase-induced osteoarthrosis was characterized by sclerosis of the subchondral bone, patellar dislocation, osteophyte formation, synovial proliferation and by severe cartilage abrasion, particularly on the medial side of the femoro-tibial joint. The overall distribution of CGRP and SP fibres was the same as in the control joints. However, major differences were found in all studied joints at specific locations around the cruciate ligaments, in the synovium around the patella, in the soft tissues lateral of the patella and in plica tissue between the patella and femoral groove. The CGRP and SP innervation was no longer detectable by immunolabelling with the antibodies. With a polyclonal antibody to the growth associated protein GAP-43/B-50, signs of degenerated axonal profiles were observed in these locations. At other peripheral locations, such as the muscles, the GAP-43/B-50 distribution was normal. In conclusion, the present study provides detailed information on the localization of CGRP and SP fibres, which may be involved in pain perception. Knowledge of the changes that occur during arthrosis may give more insight into the clinical symptoms.
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PMID:Calcitonin gene-related peptide, substance P and GAP-43/B-50 immunoreactivity in the normal and arthrotic knee joint of the mouse. 128 63

Focused ultrasound has been used to induce the following skin sensations: tactile and temperature ones; specific and unspecific pain, underskin or deep sensations: tactile sensations and some varieties of pain (muscle, periosteum and so on). It has been established that: somatic reception is attributed to mechanoreception; the same receptive structures are cold and warm ones; ultrasound has the sensibilized action. Sensation differences of corporal and auricular acupuncture points and some accidental skin underskin spots have been investigated.
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PMID:[Focused ultrasound in research on somatic reception]. 143 17


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