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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Local analgesia can be produced by transcutaneous electrical stimulation of peripheral nerves. This is used in the treatment of chronic pain states. Its clinical effectiveness depends on two points; namely (1) the stimulation has to be perceptible, and (2) paresthesias elicited by TNS must be localized in the area of pain. To verify this in healthy subjects we produced an experimental pain by radiant heating of the skin and tested the analgesic effect of TNS. TNS stimuli parameters (duration, amplitude and frequency) were determined so that double blind conditions were given. Stimulation with small rectangular pulses showed the best analgesic effect especially at a stimulation rate of 100 Hz. The stimulation of various nerves showed that most of the analgesic effects depend on spinal level mechanisms but probably long loop effects are involved.
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PMID:TNS-evoked long loop effects. 31 54

Acute studies performed in five patients indicate that electrical stimulation of the brain could be a powerful tool for the reduction or control of intractable pain. While chronic or spontaneous pain could be relieved by stimulation of the periaqueductal gray matter, the accompanying side effects render it impossible to stimulate this site regularly. On the other hand, stimulation of medial thalamic sites, particularly medial to the nucleus parafascicularis, yielded good relief of chronic pain at parameters which did not cause many undesirable side effects. The same parameters also produced inhibition of acute pain in two of the five patients.
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PMID:Pain reduction by electrical brain stimulation in man. Part 1: Acute administration in periaqueductal and periventricular sites. 32 30

The efficacy of nefopam, a novel analgesic agent, was compared to pentazocine in a double blind study in 40 cancer patients with chronic pain. Both drugs were administered orally for 10 days. Pain relief after nefopam was at least as good as after pentazocine. Side efftects after nefopam were different in nature and less frequent than after pentazocine; respiratory depression or sedation were no observed.
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PMID:[Analgesia with mild side effects]. 33 98

Stimulation of the brain has been shown to effectively suppress the clinical pain states due to central nervous system lesions. The effective stimulation site is within the somatosensory system. Stimulation in the periventricular gray matter can produce profound analgesia and effective clinical relief of chronic pain states when they are due to lesions involving the peripheral structures. This system probably is effected by activating a descending tract in the dorsal lateral fasiculus of the spinal cord impinging upon neurons in lamina 5 and lamina 1 of the dorsal bone. Stimulation in this system has not been found to be effective in patients with central lesions, which might have been anticipated in view of the anatomical relationships presented.
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PMID:Brain stimulation for the suppression of the intractable pain. 34 15

In a double-blind, 5-way crossover designed study, single doses of placebo, 2 doses of codeine sulfate (60 and 120 mg), and 2 doses of benzopyranoperidine (2 and 4 mg) were administered orally to 35 patients who required analgesics for chronic pain due to malignancies. Benzopyranopyridine is an analogue of delta-9-tetrahydrocannabinol and was chosen on the basis of its sedative, hypnotic, and analgesic properties in animals. Pain relief scores indicated a degree of relief of clinical significance with 120 mg of codeine but no consistent difference between placebo and any other active agent. On the basis of the data, bezopyranoperidine (2 or 4 mg) is not as effective as codeine (120 mg or 60 mg) and not more effective than placebo in relieving pain due to cancer; indeed, pain perception appeared to be augmented by both doses.
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PMID:Effect of benzopyranoperidine, a delta-9-THC congener, on pain. 35 40

Gave 55 chronic pain patients the Pain Apperception Test (PAT), the MMPI, the Health Index Index, the Whitely Index, the Pain Estimate, and the Tourniquet Test in an investigation of the concurrent validity of the PAT. The results did not support strongly the concurrent validity of the PAT, given the small number of significant correlations obtained. However, several consistent patterns did emerge: The PAT appeared to be correlated positively with the Alcoholism and Social Introversion scales of the MMPI and with the Invalidism scale of the Health Index. The PAT appeared to be correlated negatively with the Psychopathic Deviate scale of the MMPI. The latter results are discussed with respect to the psychodynamics of chronic pain patients. Further research is suggested, especially with regard to direct pain measures and predictive validity.
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PMID:The pain apperception test: an investigation of concurrent validity. 35 53

Of 6 outpatients with chronic pain, 5 completed therapy based on a 3-part treatment package designed to provide symptom control, stimulus control and social system modification. Each of the components of the treatment package resulted in therapeutic change. A mean of 35.8 weekly hour long therapy sessions resulted in statistically significant decreases in pain, hopelessness, depression and analgesic medication intake. Generally, these improvements were maintained at 6 months and 1 year follow-up. This study is consistent with the notion that chronic pain is maintained by a combination of inter- and intrapersonal factors. A controlled comparison of this treatment program with other treatments for chronic pain is indicated.
Pain 1978 Aug
PMID:A pilot study of the treatment of outpatients with chronic pain: symptom control, stimulus control and social system intervention. 35 68

A computer-based system to assess and quantify three components of the chronic pain experience is described. The system produces a Pain Profile and classification for each patient based on a mathematical comparison of the pathophysiologic, psychological and behavioral aspects of chronic pain. This computer-based evaluation assists the researcher in analyzing the relative importance of the chronic pain components and helps direct the clinician to the appropriate emphasis of therapy.
Pain 1978 Oct
PMID:The pain profile: a computerized system for assessment of chronic pain. 36 71

Two trials of chlorprothixene were carried out, mainly on patients with moderate to severe post-herpetic neuralgia. When the drug was given as 50 mg b.d. to outpatients, unpleasant side-effects were more important than slight effects in alleviating pain. When the drug was given as 50 mg 6 hourly to inpatients for 5 days only, there was alleviation of constant chronic pain in a third of the patients; the effect is still lasting over a period of months in a few patients. The side-effects during the course of treatment are prominent. It is concluded that the drug is worth trying in the course recommended by Farber and Burks [1] when other means of controlling postherpetic neuralgia have failed. It would be best to give the course only to inpatients.
Pain 1978 Dec
PMID:Chlorprothixene (taractan) in post-herpetic neuralgia and other severe chronic pains. 36 3

Sixteen phantom limb pain patients were treated with a combination of (1) progressive muscle relaxation exercise, (2) feedback of stump and forehead muscle tension, and (3) reassurance about normal phantom sensations and the relationship between anxiety and pain. Fourteen of the patients had chronic pain (average of 12 years) and two were recent amputees (5- and 1-week). At the end of treatment, 8 of the chronic patients showed virtually complete relief from pain, 4 showed significant decreases to a point at which they no longer desired treatment and 2 showed no significant change. Both recent amputees showed complete relief from pain. These changes have been sustained for follow-up period of 6 months to 3 years. The 2 unsuccessful patients did not learn to relax and had strong psychological needs for their pain.
Pain 1979 Feb
PMID:Treatment of phantom limb pain with muscular relaxation training to disrupt the pain--anxiety--tension cycle. 37 Jul 38


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