Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 24-year-old man presented with a rare chondroblastoma of the temporal base manifesting as local pain accompanied by difficulty in opening the mouth. Gross total removal was achieved at initial surgery, but the tumor demonstrated rapid and destructive regrowth from a very small residual volume without definite histological malignant transformation. Growth activity estimated by MIB-1 staining increased spontaneously from 2.5% at the initial operation to 18.7% at recurrence. Further extensive radical tumor removal by surgeons from multiple disciplines was performed. The patient has been free of recurrence for 3 years without radiotherapy. Chondroblastoma of the temporal bone is widely accepted as a benign tumor and regrowth after gross total removal is very rare. However, some cases of chondroblastoma have potentially high mitotic activity.
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PMID:Chondroblastoma of the temporal base with high mitotic activity. 1247 18

We report three cases of inverted papilloma of the urinary bladder. Case 1. A 19-year-old male complained of pollakisuria, gross hematuria and micturition pain. Cystoscopy revealed a smooth-surfaced tumor on a stalk at the bladder neck. The tumor was removed transurethrally. Histological diagnosis was inverted papilloma. As a safe guard, intravesical chemotherapy (Adriamycin) was performed, since pathological findings revealed a small region with mild atypical cells in the removed tumor. The patients has been subsequently followed up for ten years without any evidence of recurrence. Case 2. A 63-year-old male was admitted to our hospital because of a bladder tumor incidentally found by abdominal ultrasonography. The tumor was removed transurethrally. Histological diagnosis was inverted papilloma. The patient has been subsequently followed up for one year without any evidence of recurrence. Case 3. A 71-year-old male complained of pollakisuria, loss of urinary force and interruption of the urinary stream. A smooth-surfaced tumor found at the bladder neck was removed transurethrally. Histological diagnosis was inverted papilloma. Three months later, cystoscopy revealed two sessile papillary tumors on the left lateral wall of the urinary bladder. Pathological diagnosis was transitional cell carcinoma (G2, pTa). Although the inverted papilloma is a benign tumor, there is a possibility of recurrence or development of transitional cell carcinoma. Therefore, we advocate periodical follow-up examinations.
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PMID:[Inverted papilloma of the urinary bladder: three case reports]. 1249 19

Determining the appropriate treatment of a benign tumor of a peripheral nerve in the foot and ankle region presents a clinical dilemma, as resection of the tumor will cause loss of nerve function and create the possibility of a painful neuroma. Several surgical solutions to this problem were used in the care of a patient who presented with painful bilateral Morton's neuromas and was found to have bilateral schwannomas on pathologic examination of the resected nerves. Subsequent evaluation for recurrent bilateral foot pain demonstrated multiple tumors along the tibial nerve in one foot. The patient also became aware of a painful mass on the dorsolateral aspect of one foot. Review of the treatment options for this patient with multiple schwannomas provides a framework for decision making in the care of the patient with benign neural tumors of the foot.
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PMID:Multiple schwannomas of the foot. Case report and strategy for treatment. 1253 57

The third generation dye lasers are pulsed dye lasers with a wavelength of 595 nm. Hemangiomas are the most common benign tumor in infancy, and ulceration is their most frequent complication. We used a 595 nm, Dermobeam 2000 laser (from Deka MELA Calenzano, Italy), using a dynamic skin cooling system (Spray) as the cooling method. The diameter of the spots was 7 mm, the energy density (fluence J/cm2) from 4 to 8 J/cm2. The emission modality (repetition rate) was repeated at 0.5 Hz. We initially chose a long pulse duration of 30 msec, but in the majority of cases it was 0.5 msec. The SmartSpray Cooling system parameters were : freezing, flood, duration, and advance. The spray length was from 60%. The delay (advance or anticipation) was 10 msec. The anesthetic effect limited the need for additional topical, local or general anesthetic. In a prospective study, we treated 16 patients with 22 cutaneous hemangiomas from July 2000 to February 2002 (over a 19 month period), with a mean follow up of 22.44 months (10 to 42 months). Our purpose was to review the therapeutic response of ulcerated hemangioma to the third generation pulsed dye laser. The female/male sex ratio was approximately 3 :1 (12 girls, and 4 boys). Patients were aged from 1 to 15 months, for a mean of 4.9 months. We tried to evaluate the therapeutic response of ulcerated hemangiomas to 595 nm wavelength pulsed dye laser. We observed no adverse effects; however 2 failures due to pain were recorded from ulcerated hemangiomas as the severity of the subcutaneous component of the mixed hemangiomas remained unchanged. These 2 cases showed proliferation of the subcutaneous component, and required general corticosteroids. We examined the children about 10 to 15 days after the first treatment, and evaluated the residual pain. The treatment could be continued while the pain level is low (1 session in most cases), and until the ulceration heals (after 4 sessions). Laser therapy was always effective on severe bleeding, but recurrences were frequent and it was necessary to treat hemangiomas until the end of the cicatrisation. Laser therapy is indicated for hemangiomas only in rare instances : due to the refractory ulceration failing to heal after 2 weeks of specialized dressing, aesthetic risk due to localization (such as philtrum, columella, or nasal margin). It is also possible to treat residual telangiectasia. No uniformly effective treatment modality was found.
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PMID:Treatment of hemangiomas with 595 nm pulsed dye laser dermobeam. 1269 28

A nine months old Japanese domestic cat with a solitary bone cyst, which is a benign tumor-like lesion and is particularly uncommon in feline practice was referred. Radiographic examination revealed an expansive radiolucency in the distal metaphysis of the right ulna and pathologic fracture. The histological examination demonstrated immature osteogenesis consisting of osteoblasts surrounded by connective tissue. We applied drainage and instillation of steroid solution into the cystic cavity. Clinical signs, including lameness and pain, disappeared three weeks after the therapy started. Fourteen months after the therapy, the cystic lesion of bone was remodeling successfully without re-developing. We conclude that our procedure was useful treatment in this case.
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PMID:Steroid injection therapy in a feline solitary bone cyst. 1273 37

Synovial hemangioma is a rare benign tumor of joint cavities. It may be a cause of pain and recurrent joint swelling in children and young adults. Diffuse synovial hemangioma was diagnosed in a 25-year-old male patient with complaints of right knee pain and swelling of a 10-year history. Direct radiography, venography, magnetic resonance imaging, and diagnostic arthroscopy enabled the diagnosis. Surgical excision was not considered because of diffuse involvement and many pigmented areas in the skin; instead, the patient was monitored conservatively. At the end of a year, the severity of complaints and the size of the lesion did not increase. Since there is a high risk for recurrence following open synovectomy for diffuse synovial hemangiomas, conservative treatment may be an alternative approach in selected cases.
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PMID:[Diffuse synovial hemangioma of the knee: a case report]. 1534 24

Solitary osteochondroma of calcaneum is an uncommon benign tumor. Its malignant transformation to chondrosarcoma is rarely encountered. Pain and recent enlargement are clinical manifestations of this complication. Magnetic resonance imaging is a valuable tool to detect this change.
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PMID:Transformation of solitary osteochondroma calcaneum to chondrosarcoma--a case report. 1547 Nov 26

Osteoid osteoma is a small benign tumor that requires treatment due to the intense pain it causes. Surgical therapy has been the ablative technique of choice after a failure of medical therapy. Recently, numerous less invasive, alternative procedures have been proposed: drill trepanation with or without ethanol injections, cryoablation, and thermoablation with laser or radiofrequency. The aim of this review is to retrospectively assess the effect of radiofrequency (RF) thermoablation in the treatment of primary non-spinal osteoid osteoma. From June 2001 to July 2003, we treated 106 patients affected by osteoid osteoma with RF thermoablation. Five patients with spinal osteoid osteoma and four with a previously treated osteoma were excluded from the study. In this paper, we assess the results obtained in a selected group of 97 primary non-spinal osteoid osteoma. The lesions were predominantly in the metaphysics of the femur. Central nidus calcifications were frequent and there was no prevalence for which side they occurred. Primary success was achieved in 82 patients (85%), while we obtained secondary success in 15 patients (15%). In two patients (2%), pain persisted between the two treatments and failed to be resolved, even after the second treatment; therefore, surgical excision was performed and complete resolution was obtained. No complications were reported. In conclusion, our results confirm that the treatment of choice for non-spinal osteoid osteoma is RF thermoablation, offering several advantages over ablative techniques.
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PMID:Radiofrequency thermoablation of primary non-spinal osteoid osteoma: optimization of the procedure. 1575 55

Osteoid osteoma is a small benign tumor, with a ''nidus'' that rarely exceeds 15 mm in diameter. It is relatively common in males, especially teenagers and young adults. It involves mainly the appendicular skeleton, the femur in particular, and rarely the axial skeleton. It requires treatment because it causes intense pain. In recent years alternative, less invasive, treatments have been proposed, such as drilling combined with ethanol injections, and thermal ablation with laser or radiofrequency. This study assesses 117 patients affected by osteoid osteoma, treated by radiofrequency thermal ablation between June 2001 and November 2003. We describe the patient recruitment procedure, CT-guided technique, the percutaneous approach, thermal ablation, and the instruments used. Data were analyzed thoroughly, and modifications that have improved the effects of treatment have been highlighted. The results achieved since the method was perfected have been extremely encouraging, confirming that the technique is very effective if performed correctly. For that reason radiofrequency thermal ablation has become the treatment of choice for non-spinal osteoid osteoma at Rizzoli Orthopaedic Institute.
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PMID:Radiofrequency thermal ablation of non spinal osteoid osteoma: remarks on method. 1597 30

Thymolipoma is an uncommon benign tumor (accounting for 2% to 9% of thymus tumors). We present the case of a 26-year-old man who sought medical attention for left-sided pleural pain of 3 months duration. Computed tomography showed a mass in the left side of the chest occupying both the anterior mediastinum and the left pleural cavity. This mass caused lung collapse and mediastinal shift. Magnetic resonance imaging revealed a large fatty tumor and transthoracic biopsy with radiological guidance confirmed the diagnosis. The tumor was resected through a left thoracotomy. No postsurgical complications occurred and the histopathological diagnosis was thymolipoma.
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PMID:[Giant thymolipoma]. 1602 36


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