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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors report on a clinical evaluation of Rigevidon, a Hungarian contraceptive produced by Gedeon-Richter. The contraceptive contains 0.15 mg d-norgestrel and 0.03 mg ethinyl estradiol. 45 women ages 20-35 received this contraceptive for between 3-18 cycles. No pregnancies were observed and the Pearl's index was 0.0/100 women/year. Adverse reactions developed in 12 women (26.67%), mostly in the form of weight gain and intermenstrual bleeding. Such adverse reactions appeared in cycles 1-3 and regressed spontaneously without treatment. In 2 cases, Rigevidon was withdrawn because of pain in an isolated crural varix. Its effectiveness and the fact that it was well-tolerated, as well as the low incidence of adverse reactions, suggests that Rigevidon is a good contraceptive. (author's modified)
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PMID:[Clinical evaluation of Rigevidon used for contraception]. 639 73

Four hundred and seventeen consecutive patients referred with significant chronic venous disorders of the lower limb have been studied. Two hundred and ninety-nine were considered to have uncomplicated primary varicose veins, with saphenous incompetence. The remaining 118 presented with past or current skin ulceration, prominent pain and swelling, or both. Ascending and descending venography and further Doppler studies revealed only 18 patients (17 with ulceration) with an incompetent long saphenous system and ankle perforators as the only identifiable abnormalities. In 12 of these, patients' dorsal foot vein pressures were measured at rest and the maximum fall demonstrable after exercise expressed as a percentage of this (12.9 per cent +/- 6.0). This test was repeated with a narrow tourniquet inflated to 160 mmHg, applied to the mid-thigh (35.6 per cent +/- 7.4) (P less than 0.05), and again after accurate groin ligation and stripping of the long saphenous vein to the knee (31.9 per cent +/- 10.7) (P less than 0.05). These results seem to validate the use of the foot pressure/tourniquet test in assessing the relevance of saphenofemoral incompetence, and suggest in a proportion of venous ulcers this is a princical factor.
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PMID:Long saphenous incompetence as a cause of venous ulceration. 648 73

Impedance plethysmography (IPG) and the Doppler ultrasonographic probe were used to assess whether thrombophlebitis, initiated by injection of a sclerosant into superficial varicose veins, extended to involve the deep veins of the leg. Sixty-seven legs were treated with compression sclerotherapy in 50 patients (26 men, 24 women) whose mean age was 53 years. Indications for this therapy were unacceptable appearance (n = 37), pain (n = 13), cramps (n = 11), and stasis ulcer (n = 6). Each leg received an average of six injections (range, three to 11) of 0.5 mL of sodium tetradecyl sulfate. Blood flow in the deep veins was studied immediately before injection of the sclerosant and one week and two weeks afterward. In each leg, no change in either of these studies was found at one and two weeks following injection treatment. In nine extremities, delayed venous emptying was found on IPG. This persisted after sclerosis and was interpreted as evidence of a previous deep vein thrombosis.
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PMID:Sclerosant treatment of varicose veins and deep vein thrombosis. 649 33

Postphlebitic syndrome occurs in 20 per cent of patients with deep vein thrombosis. Symptoms are nonspecific; they include heaviness, fatigue, pain, and vary from patient to patient. The signs of edema, skin pigmentation, dermatitis, varicosities, and ulceration are a result of the increased retrograde venous pressure secondary to the valve destruction by the phlebitic process. The aim of therapy is to improve venous support by graduated elastic stockings and to ensure good skin care and exercise.
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PMID:Postphlebitic syndrome. 653 97

Twenty-five patients with congenital arteriovenous malformations (AVMs) involving the head, neck, trunk, or extremities were treated over a 10-year period. In patients with more extensive lesions, selective angiography was essential to delineate the extent of the AVM and its vascular anatomy. AVMs that produced congestive heart failure, hemorrhage, pain, or cosmetic embarrassment were excised if possible. Intra-arterial embolization is useful in the reduction of vascularity before operation or as the primary treatment for unresectable lesions. Incomplete excision or embolization of the AVM often results in a recurrence. However, nonsymptomatic lesions may be observed, and extremity varicosities can be treated by external compression.
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PMID:Management of congenital arteriovenous malformations. 663 37

The efficacy of mild analgesics after 160 various superficial operations was studied by comparing intravenous lysine-acetylsalicylate (LAS) 1.8 g, Litalgin 4 ml (metamizole = dipyrone 2.0 g+ pitophenone 8.0 mg) or paracetamol 0.5 g to oxycodone 4 mg. At 15 min postdrug, oxycodone 4 mg had the best peak effect but this significant (P less than 0.05) difference to mild analgesics disappeared at 30 min, and thereafter all test analgesics showed an equally low effect. Two-thirds of the patients anaesthetized without peroperative analgesics needed pain relief when recovering from superficial surgery. The need for pain relief was lowest after varicose vein operations 40% of the patients as compared to about 70% after other types of superficial surgery. In 42% of the patients requiring pain relief, the test analgesics alone gave sufficient pain relief. The rest needed an additional 5 mg of oxycodone, on average, to be comfortable. The combined use of mild analgesics and oxycodone for adequate pain relief did not seem to reduce the postdrug sedation as compared to oxycodone alone. The results indicate that in traditional clinical dosages LAS, dipyrone or paracetamol can substitute about 5 mg oxycodone but offer sufficient analgesia only in about 40% of the patients recovering from superficial surgery.
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PMID:Postoperative analgesics for superficial surgery. Comparison of four analgesics. 681 Jun 42

Graded elastic compression stockings on the lower leg were evaluated for their ability to (1) decrease leg volume, (2) decrease circumference, and (3) alleviate discomfort. One hundred three test subjects participated in this study, including 30 normal, asymptomatic control subjects. The conditions of the 73 symptomatic patients were categorized by pain and swelling, varicose veins, venous stasis, lymphedema, and phlebitis, which constituted symptoms in 120 legs. Although total body weight did not change during the week of observation, the volume, circumference, and pain decreased in the symptomatic group. The volume of the stockinged leg decreased in comparison with the nonstockinged control leg in the asymptomatic subjects as well. We conclude that non-custom-made graded elastic stockings with 24 mm Hg of pressure at the ankle are effective in decreasing volume, circumference, and symptoms in the lower leg in patients with minimal problems during a one-week period.
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PMID:Efficacy of graded elastic compression in the lower leg. 684 11

Compression sclerotherapy is not surgery-free, is not a cure, and rarely produces a "Hollywood leg". Repetitive injections are necessary for cosmetic control. The use of injection-compression for large thigh varicosities associated with saphenofemoral incompetency led to an inordinately high recurrence rate in this study, despite good initial results. By increasing the number of injections at the first session, 75 percent of the limbs were treated in a single session. The reinjection rate to maintain control was approximately 5 percent per year over the 7 year follow-up period. Compression sclerotherapy is an effective method of controlling venous perforators. Patients with bursting pain, severe signs of stasis, or ulceration are ideal candidates. It is particularly applicable to patients who are elderly, obese, or at high risk for other reasons and is a very useful tool in the management of venous disease. It is also very well accepted by patients. The technique should be more widely taught and practiced in North America.
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PMID:Compression sclerotherapy: preparation, technique, complications, and results. 688 46

Lysine acetylsalicylate (LAS) is a soluble salt of acetylsalicylic acid and can be given parenterally. LAS 12.5 mg kg-1 and 25 mg kg-1 were compared with oxycodone 0.15 mg kg-1 in the treatment of pain after operation in 60 patients undergoing varicose vein surgery. Both treatments almost completely relieved moderate to severe pain for the 3-h observation period. The time until the peak of action was longer after LAS (60-90 min) than after oxycodone (30-60 min). No significant differences were found between the smaller and larger doses of LAS, suggesting a plateau effect. Further clinical experiments with LAS using i.v. mode of administration and other pain models are warranted.
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PMID:Comparison of i.m. lysine acetylsalicylate and oxycodone in the treatment of pain after operation. 700 Jan 6

A double blind controlled trial of surgery for varicose veins was conducted on the legs of patients with bilateral symmetrical varicose veins. The two treatments, saphenofemoral ligation and avulsion of varices, with and without stripping of the long saphenous vein from ankle to groin, were randomly allocated among the legs of individual patients. At follow-up, between 2.5 and 3.5 years, an objective (observer) assessment was that stripping conferred a significant advantage, but the incidence of paraesthesia and pain biased patient's opinion against stripping.
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PMID:To strip or not to strip the long saphenous vein? A varicose veins trial. 701 44


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