Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors report their 2-year experience of esophageal endoscopic sclerotherapy for prevention of recurrent variceal bleeding in patients with liver cirrhosis. Sixty-three alcoholic cirrhotics underwent sclerotherapy 10 +/- 6 days (SD) after hospital admission for variceal bleeding. Varices were successfully eradicated in 43 patients (68 p. 100), with an average of 3 injection sessions, over a mean period of 5 weeks. Unsuccessful treatment was due to abbreviated course of treatment because of early rebleeding and early mortality. Early rebleeding episodes after therapy occurred in 19 patients (30 p. 100): 10 in whom the esophageal varices were eradicated, 9 in whom sclerotherapy had failed. Recurrent hemorrhage was the cause of death in 6 patients. After variceal eradication had been achieved, new varices were observed in 7 p. 100 of patients after a mean follow-up of 8 months. The risk of further variceal bleeding was 0.008 hemorrhage/patient/month. Minor complications (thoracic pain, dysphagia, esophageal ulcers, pleural effusion) occurred in 60 p. 100 of patients. An esophageal stricture developed in 13 out of the 43 successfully treated patients (30 p. 100). Major complications occurred in 5 patients and was the cause of death in 4: mediastinitis, esophageal perforation, bronchoesophageal fistulae, cardiogenic shock and aspiration pneumonitis. The survival curve, assessed by cumulative life analysis, showed a 60 p. 100 survival rate after 12 months and 56 p. 100 after 18 months. It was significantly different (p less than 0.001) between groups of cirrhosis classified according to Child-Pugh's criteria (95, 52 and 9 p. 100 at 12 months for groups A, B and C respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Evaluation of 2 years' experience with elective endoscopic sclerotherapy of hemorrhagic esophageal varices in cirrhotic patients]. 387 11

The CO2 laser has several distinct advantages in its application to soft tissue lesions of the foot. A dry field is obtained with good hemostasis and clear vision, with easy access in confined areas. The laser beam sterilizes as it cuts, reducing the incidence of infection. In sealing lymphatic channels, it may theoretically diminish the risk of metastasis in malignant lesions. Healing occurs with minimal postoperative swelling, scarring, or pain, leading to increased patient comfort. Other areas in which the laser can be helpful are porokeratosis, keloids, spider web varicosities, and tattoos.
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PMID:The carbon dioxide laser in podiatric medicine. 392 17

Since 1968 the author treated 273 cases of venous disorders in women using oral contraceptives. Only 5 cases of deep thrombosis were definitely related to pills. There were 11 cases of deep thrombosis, 14 of superficial thrombosis, 87 of varicose veins, 28 of telangiectasia, 14 of edema and 56 of functional disorders, e.g., heaviniess or pain in limbs. The frequency of venous disorders among pill users is higher than in the normal female population, especially in the first few cycles, but is decreasing as pills with lower doses are introduced. The author attempted some experiments in rats: histological studies of veins showed no changes; other studies were conducted on vein contractility, elasticity and hydrostatic pressure. The nature of vein alterations induced by pills is similar to that seen in pregnancy; although unknown, it may involve loss of venous tone or openning of arterio-venous anastom oses. To manage pill indications and contraindications, the author classified patients into a) those with no history of or current vein disorders can use pills; b) those with personal or familial contraindications or predisposing factors should not take pills; c) 1) those with vein disorders under treatment who have relapses should stop pills; 2) those who have no relapses can continue; 3) those with only mi ld aggravation should stop pills for 3 months, then resume to see whether the recurrence was pill related.
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PMID:[Synthetic estroprogestatives and circulatory disorders]. 466 48

45 women with a history of lower-abdominal pain of more than 6 months' duration for which no obvious cause had been found during laparoscopy (pelvic-pain syndrome) were investigated with transuterine pelvic venography. For comparison venography was carried out on 10 women in whom pathology was considered to be a likely cause for their pain and 8 women admitted for tubal ligation and who had no pain. Pelvic varicosities and congestion unrelated to parity or the menstrual cycle were commonly found in women with the pelvic-pain syndrome. A score for quantifying the severity of the pelvic vascular abnormalities has been devised; a value of 5 or more gave a diagnostic sensitivity of 91% and a specificity of 89% for the pelvic-pain syndrome.
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PMID:Diagnosis of pelvic varicosities in women with chronic pelvic pain. 614 42

Nerve fibers in the dental pulp of the lower molar teeth of the rat exert fluoride resistant acid phosphatase (FRAP) activity. FRAP-positive axons establish a three-dimensional nerve plexus within the pulp; the individual axons are very fine (calibre less than 1 micrometer) and only their varicosities measure 1...2 micrometer in diameter. Electron microscopically, FRAP-positive amyelinate axons containing lysosomes are partly embedded in Schwann cells. Removal of the cervical superior ganglion does not induce any alteration of FRAP-positive axons, while destruction of the Gasserian ganglion results in Wallerian degeneration. No FRAP-positive nerve fibers were found in rat incisors. Since, in the rat, only molar teeth are equipped with nociceptive terminals while continuously growing incisors lack pain fibers, it is concluded that FRAP-positive varicose axons in the dental pulp represent nerve endings of trigeminal primary nociceptive neurons.
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PMID:Fluoride-resistant acid phosphatase (FRAP) activity of nociceptive nerve terminals in the dental pulp. 619 34

The presentation of cystitis associated with lumbago in a young woman lead to the discovery on IVU of left pyelitic irregularities. Ultrasound demonstrated a non-homogeneous lateral pyelitic mass. Because we suspected a vascular aetiology, we performed arteriography: arteries were normal, the renal vein was not visualized, but opacities caused by peripyelitic varices being drained by a much dilated lumbo-ovarian vein which gave a normal intramyometrial phlebographic picture, were seen. Selective catheterization of the renal vein was not possible to perform. Was this then a case of agenesis or thrombosis? Tomography didn't help decide. The persistence of severe pain contraindicated lumbotomy, and the presence of a wide but flat and impermeable renal vein. A complete denervation of the kidney was carried out. The normal artery and the ovarian vein were preserved intact. The follow-up was straight forward-routine IVU was normal. The pains disappeared.
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PMID:[Left renal vein thrombosis with exception diagnostic circumstances. Success of an unusual surgical treatment]. 621 65

The authors report on a retrospective study of 184 laparoscopies carried out assessing the aetiology of chronic pelvic pain. The population that was studied has a mean age of 28.8 years, with most of the patients being between 20 and 30 years of age. The mean length of the history of the pain was 51 1/2 months. 51% of the cases had pain of a rhythmical nature associated with the menstrual cycle, 11.3% of cases had deep dyspareunia and 37.7% of the cases had repeated attacks of pain. Previous gynaecological pathology was found in 30% of cases and previous pelvis surgery in 11.1% of cases. 41.5% of the population were multiparous. Laparoscopy was only performed after a full clinical and paraclinical examination. It showed the presence of: endometriosis in 22.2% of cases, pelvic adhesions in 17.4%, varicose veins in the pelvis in 11.4%, ovarian cysts in 6.5%, ovarian dystrophies in 3.2%, Masters and Allen syndrome in 3.8%, sub-serous fibroids in 2.1%.
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PMID:[The diagnostic value of celioscopy in the evaluation of chronic pelvic pain. Apropos of 184 cases]. 623 46

We have studied the ultrastructural features of sensory nerve fibers in the ciliary body and the iris and their parent trigeminal ganglion cells, using intra-axonally transported horseradish peroxidase as a tracer. Unmyelinated nerve fibers of ipsilateral trigeminal origin were found in stroma of both the ciliary body and the iris. Most appeared in bundles of nerve fibers; but some were found singly. Two distinct types of varicosities were found, one containing both a few irregularly shaped vesicles and mitochondria, the other containing mitochondria only. The thin profiles of the axons between these varicosities or endings contained neurotubules and filaments. The trigeminal ganglion cells supplying the anterior eye were of a relatively small size (15-50 micron in diameter) and confined to the anteromedial part of the ipsilateral ganglion. These cells could not be classified according to the arrangement of their subcellular organelles. The morphological characteristics of the sensory nerve fibers and ganglion cells supplying the anterior uvea are consistent with the view that pain may be the predominant sensation mediated by these neurons.
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PMID:Sensory supply of the anterior uvea: a light and electron microscope study. 633 30

In a study designed to compare the efficacy and safety of two techniques of injection sclerotherapy, 40 patients (30 with cirrhosis and 10 with portal vein block) were randomly allocated to the sheath or free-hand technique. Although the former was associated with significantly less bleeding within the first 24 hr of injection (p less than 0.05) but more postinjection pain (p less than 0.05) and esophageal stricture, there was a trend toward earlier obliteration of varices. This was most marked over the first three courses of injection, and although frequency of rebleeding was not significantly less, none of the 11 episodes in the sheath group were fatal, compared to 5 of 15 bleeds in those injected by the free-hand technique (p less than 0.05).
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PMID:A prospective randomized study of two sclerotherapy techniques for esophageal varices. 635 48

A prospective randomised study to compare the efficacy and complications of injection sclerotherapy carried out at intervals of one week and three weeks up to the time obliteration of varices was achieved, was undertaken in 55 patients (48 cirrhosis, six portal vein thrombosis, one nodular regenerative hyperplasia). The number of courses of injection required for obliteration of the varices was not different in the two groups and despite a shorter time scale for obliteration in the weekly treated patients the frequency with which further episodes of bleeding occurred before that was not significantly less. Mucosal ulceration during the period required for obliteration was observed at endoscopy more frequently in the weekly treated patients but was not associated with a greater frequency of postinjection pain, dysphagia or of long term stricture formation.
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PMID:Injection sclerotherapy for oesophageal varices: a prospective randomised trial of different treatment schedules. 636 16


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