Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of alcoholic ketoacidosis in a 23-year-old chronic alcoholic, gravada V, para IV, is reported. Symptoms were constant, severe, nonradiating pain with crampy exacerbations, anorexia, nausea and vomiting. The patient had a tender and irritable full-term uterus. She was treated inhospital with vigorous fluid therapy and 5% dextrose in normal saline, sodium bicarbonate, glucose and insulin and showed improvement overnight. Alcoholic ketoacidosis has not been reported in pregnant women. Metabolic derangements combine to produce ketoacidosis more readily in the pregnant alcoholic. Differentiation of alcoholic ketoacidosis and diabetic ketoacidosis is important since treatment varies. For alcoholic ketoacidosis, treatment is vigorous rehydration with dextrose-saline while diabetic ketoacidosis usually requires multiple therapeutic modalities.
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PMID:Alcoholic ketoacidosis in a pregnant woman. 11 97

A 32 year old female patient showed multiple plaque-like leiomyomata cutis and an uterus myomatosous of early onset. In the skin large areas of plaque-like confluent erythematous nodules consisting of smooth muscle tissue are formed. The patient suffered from frequent attacks of severe pain elicited by temperature changes or trauma. Treatment with nitroglycerine and nifedipine together with phenoxybenzamine completely suppressed the symptoms.
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PMID:Leiomyomatosis cutis et uteri. 11 8

Prostaglandins are highly potent derivatives of unsaturated fatty acids with multiple biological activities. They are synthesized and metabolized in almost all tissues studied so far. The E- und F-type prostaglandins may be regarded as local modulators of hormonal effects on cell function and--in some cases (kidney, uterus-corpus luteum)--as regional or tissue hormones. Thus they seem to be involved in the regulation of neurotransmission, kidney function, triglyceride metabolism in adipose tissue and progesterone biosynthesis. Apart from their influence on renal blood flow prostaglandins of the A-type possibly have an additional function as circulatory hormones regulating blood pressure. Second messenger-systems (cAMP, Ca++-cGMP) which mediate the effects of most non-steroidal hormones are also involved in the action of prostaglandins, at least of the E-and F-types. Disturbances in prostaglandin metabolism (increased or decreased biosynthesis) are discussed to play a role in the pathogenesis of inflammation, pain, fever, hypertension, bronchial asthma and gastric or duodenal ulcer formation. Drugs with antiinflammatory, analgesic and antipyretic activity have been shown to be potent inhibitors of prostaglandin formation. The correlation of a local prostaglandin deficit or the therapeutic use of single effects of prostaglandins by administration of exogenous compounds (natural prostaglandins or modified derivatives) has so long been less satisfactory because of their large number of biological actions which lead to undesired side effects. Extensive experience have been obtained in the successful induction of therapeutic abortion. This effect is based on the stimulatory action of E- and F-type prostaglandins on the smooth muscles of the pregnant uterus which is resistent to the influence of other stimuli, e. g. oxytocin. Here the incidence of side effects could be reduced by local administration of low doses of prostaglandins into the uterine cavity. A general improvement of the therapeutic usefulness of prostaglandins will however only be achieved, if modified derivatives with more specific actions on the desired "target" tissues are available.
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PMID:[Biology of prostaglandins with reference to therapeutic aspects]. 16

The efficacy and side effects of a new synthetic compound, 16-phenoxy-W-17, 18, 19, 20-tetranor prostaglandin E2 methylsulfonylamide, for menstrual induction. The study was conducted in an outpatient clinic in 240 patients with a delay in menstruation of 6-14 days. In 206 patients (86%) the immunologic pregnancy test was positive before prostaglandin administration. Most of the remaining 34 (14%) patients with a negative pregnancy test had symptoms suggestive of pregnancy. Whenever there was doubt that amenorrhea was due to reasons other than pregnancy, the patients were not treated with prostaglandins. The patients' age range was 16-32 years; the parity range was 0-6. The treatment was successful in 228 patients (95%), i.e., there was uterine bleeding after prostaglandin administration followed by a negative pregnancy test within 14 days. In 6 patients with failed treatment, there was uterine bleeding after prostaglandin administration lasting for 2-13 days but the pregnancy remained positive. Prostaglandin failed to induce bleeding in 4 patients. In 3 of the patients the pregnancy test was positive before and 14 days after prostaglandin administration. The uterus was evacuated by vacuum aspiration in 9 patients. In 1 patient who had no uterine bleeding, pregnancy test was negative both before and 2 weeks after prostaglandin administration. 2 patients were admitted to the hospital the day after prostaglandin treatment for excessive bleeding. Curettage was carried out in both these patients and the bleeding stopped. 1 patient was readmitted to the hospital 8 hours after prostaglandin administration with severe pain in the lower abdominal region. On further examination a tubal pregnancy was diagnosed and confirmed by laparotomy. 2 patients were successfully treated for pelvic infection with antibiotics 7-10 days after prostaglandin administration. All patients experienced mild uterine pain a few minutes after prostaglandin administration. 16 patients required analgesics. The majority of the patients described the bleeding as heavier and longer in duration than their normal menstrual period. The average length of bleeding was 7.3 days with a range of 2-13 days. Side effects included 1 or 2 episodes of vomiting in 13 patients and headache in 9 patients.
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PMID:Termination of early pregnancy (menstrual induction) with 16-phenoxy-omega-tetranor PGE2 methylsulfonylamide. 20 Apr

Some women undergo induced abortion manifest a series of symptoms such as slower heart beats, irregular heart rate, lowered blood pressure, paleness, dizziness and profuse perspiration. These symptoms, which occur during or after the procedure, are referred to as "a symptom complex." In 1977, 400 pregnant women were studied to determine the cause of this symptom complex: 263 healthy women who received normal treatment; 32 women with heart ailments associated with early pregnancy, who received acupuncture; and 105 women whose heart rates were below 90, who were injected with 0.5 mg atropine. Virtually all of the 263 women had a slower heart rate during the procedure. 33 (12.55%) of these women exhibited the symptom complex, and of these, 23 (69.17%) had cramps, 17 (51.52%) had abdominal swelling, and 2 (6.09%) had backaches. Most of these symptoms occurred when the cervix dilated and after the suction. The duration and seriousness of the symptom complex varied from woman to woman, as did the recovery period, which ranged from 3 to 63 minutes. It was also found that: 1) of the 263 patients, 110 were first time mothers, of whom 15 (13.63%) had the symptom complex; 2) of the 221 healthy women who had abortion by suction, 32 (14.48%) had the symptom complex, while 1 (2.38%) who had abortion by pincers, had the symptom complex; 3) of the 33 women who had the symptom complex, the loss of blood ranged from 10 ml to 200 ml, with an average loss of 50 ml; 4) there appears to be no relationship between the manifestation of the symptom complex and negative pressure; 5) electrocardigrams were taken for 20 of the healthy patients, none of whom showed a quickened heart rate during or after the procedure; and 6) treatment for the symptom complex was by acupuncture or by injection of Atropine. The 32 acupuncture patients suffered only backaches and lower abdominal swelling, but relief of pain was slow. 105 patients were administered Atropine, none of whom manifested the symptom complex. Only 19 women perspired slightly and felt chilled in the limbs, while 3 were nauseous. Of the 33 symptom complex patients, 5 had Atropine, most of whose heart rates returned to normal after 2 seconds to 2 minutes, as did their dizziness, perspiration, and ashen coloring. However, it was found that if no treatment was given after the symptom complex emerged, a majority of the patients returned to normal on their own, some taking as long as an hour. It is believed the occurrence of the symptom complex is directly related to the mechanical stimulus applied to the uterus or cervix, the vigorous shrinkage of the uterus, loss of blood, and the negative pressure suction power of the uterine wall. Further a mechanical stimulus to the uterus can cause an "errant" nervous reflex that will affect the heart rate. This errant nervous reflex can be cut off by an injection of Atropine.
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PMID:[A symptom-complex during artificial abortion (author's transl)]. 26 29

A study was conducted among 40 female patients who had previously undergone "incomplete" tubal operations and who, because of pelvic abnormalities, required a subsequent definitive gynecologic operation. The patients had originally undergone: 1) bilateral salpingectomy (i.e., removal of both tubes and, in some case of both ovaries, but not of the uterus); 2) bilateral tubal ligation in conjunction with uterine suspension to the abdominal wall; and 3) bilateral tubal ligation as a method of sterilization. Symptoms (pain, bleeding, or dysfunction), abnormal pelvic findings, and biopsy and curettage indicated the necessity for definitive operations. Symptoms, physical findings at the subsequent operation, and operative procedures for the subsequent operation are tabulated for each of the 3 groups of patients. Statistics from this study show that the retained uterus and cervix are the most common sites for future abnormalities.
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PMID:Sequelae of incomplete gynecologic operations: I. Uterine tubes. 27 34

An illegal abortion performed by inserting foreign objects vaginally into the uterus resulted in a septic abortion, the report of which is published here as a case study. This septic abortion was induced by introducting a bamboo stick into the uterus, resulting in a discharging sinus at the back and sacral osteomyelitis. The patient was an Indian woman, aged 35 years, who had her 5-month gestation pregnancy terminated illegally, and presented after 6 months of pain with a discharging sinus over the left buttock of 3 months duration. A sinogram and a roentgenogram of the pelvis are published which show a lytic area on the body of the sacrum, and outline the extensive sinus tract extenting from the sinus to the uterus. Under general anesthesia a 6-inch-long bamboo stick was removed from the uterine cavity and curettage was performed. Streptomycin was injected, and the patient was asymptomatic at time of hostpital discharge; she is presently 24 weeks pregnant.
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PMID:Induced abortion followed by pelvic osteomyelitis. 39 55

Early first-trimester abortions were induced by a single intravaginal pessary containing 3 mg of 15 methyl prostaglandin F2 alpha methyl ester in 17 patients. The procedure was successful in 16 patients (94%). Intrauterine events were observed by means of serial ultrasonic B scans. Pain, bleeding, and dislodgement of the gestational sac had commenced within 6 hours. Significant gastrointestinal side effects occurred in the majority of patients despite medication but they were usually of short duration. Vaginal bleeding, which was not heavy, continued for about 10 days and during most of this time the uterus contained products of conception. It is concluded that the method is effective during the first 7 weeks of gestation.
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PMID:Ultrasonic assessment of uterine emptying in first-trimester abortions induced by intravaginal 15-methyl prostaglandin F2 alpha methyl ester. 44 86

Recently, IUd usage has increased, and with that increase has come an awareness of the undesirable side effects of the device, notably infection. Infection risks can be minimized if clinicians observe aseptic and sterile procedures. Histological studies were conducted on the tissues adhering to the IUDs of 244 women. The women were aged 20-40, and had had the IUD in place for an average of 4 years. Histological rather than bacteriological studies were conducted because the presence of bacteria does not necessarily indicate that disease is present. Secretory endometrium was found in 54.8% of the women, proliferative endometrium in 32.2%, cellular debris in 4.9% and stromoglandular disassociation in 8.1%. Of the 19 women in whom disease states were detected, endometritis chronica was seen in 79% of the cases, E. purulenta in 10.5%, e. acuta in 5.25% and E. subacuta in 5.25%. All of these conditions vanished after removal of the IUD and antibiotic treatment. In none of the cases was the IUD associated with precancerous atypia. Prevention may be the best approach with respect to infectuous complications associated with IUD use. Colposcopy, culturing of cervical mucus, PAP smears, erythrocyte sedimentation and leukocyte counts should be performed on women prior to IUD insertion. These steps guard against introducing vaginal infections into the uterus. When a woman comes to a physician complaining of pain in the lower back, abdomen, or during intercourse, infection must be suspected. If infection is found, treatment to eliminate the offending organism needs to be initiated. The woman's partner may also need to be treated.
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PMID:[Prolonged use of IUD and inflammatory diseases of the inner genitalia]. 44 93

Acupuncture was used on 20 patients to induce analgesia for instrumental inspection of the uterus. The procedure was successful in 80% of cases; in 12 patients single manual manipulation of the needles was used, without electrical stimulation. There was, after the procedure, less bleeding and less pain than after regular anesthesia. Acupuncture is to be recommended in all instances in which anesthesia would entail a risk, or would generally not be advisable.
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PMID:[Acupuncture analgesia in instrumental examinations of the uterus]. 45 Mar 13


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