Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Acute simple cystitis is very easily cured by the proper use of an antibiotic. However, at times, such irritation symptoms in the bladder as micturition pain, pollakisuria and pyuria disappear. Consequently, medication to remove these irritation symptoms in the bladder at the earliest possible date, is required. However, there are no established standards for treatment in terms of the administration method and the administration period, etc. We gave a new non-steroid anti-inflammatory drug, tiaprofenic acid (SURGAM) to women suffering from acute simple cystitis who strongly complained of bladder irritation symptoms especially of micturition pain. The administration was carried out concurrently with an antibiotic, and its effectiveness was studied. As a result, micturition pain showed 86% improvement on the 1st day after starting administration, and it is thought that the concurrent use of this product with an antibiotic can probably remove the patients' complaints quickly and prevent the meaningless administration of antibiotics due to the persistence of symptoms and, subsequently, there is the possibility of shortening the period of administration.
 ...
PMID:[Effectiveness of tiaprofenic acid on clinical symptoms of acute simple cystitis in women]. 387 75

The authors present a case of a fifteen-year-old boy with urgency, suprapubic pain, hematuria, and pyuria with negative routine urine cultures. Cystoscopy revealed gross cystitis, and VCUG showed bilateral reflux and ureteral dilatation. Renal arteriograms, percutaneous renal biopsy, and bladder biopsy also were performed. After finding a positive culture for Ureaplasma, therapy with doxycycline rendered the patient asymptomatic and reflux improved on follow-up VCUG. Ureaplasma urealyticum should be considered in patients with symptomatic pyuria and negative routine cultures. Ureteral reflux, reversible with appropriate therapy, may be part of the infectious process.
 ...
PMID:Cystitis with ureteral reflux caused by ureaplasma urealyticum. 396 56

Tuberous sclerosis is essentially a hereditary disease dominated by hamartomas in various organs. Symptoms of the disease are referable to expanding growth of these hamartomas, especially in the kidney where these benign lesions most often present with pyuria, hematuria or pain from bleeding. They are apt to be erroneously diagnosed as malignant both clinically and microscopically. Renal symptomatology is most often to be found in the adult patient.
 ...
PMID:The kidney in tuberous sclerosis. 447 Sep 14

Probably because of its rarity, the IUD complication of bladder perforation has seldom been diagnosed prior to intervention. This article presents in tabular form data on 8 cases of bladder perforation by IUDs in an effort to develop appropriate methods of preoperative diagnosis. Several types of bladder perforation were found in the 8 cases. The main symptom was recurrent and persistent cystitis which usually responded only temporarily to therapy. Symptoms included dysuria, burning on urination, frequency, nocturia, occasional hematuria, lower abdominal and suprapubic pain, and bladder pressure. Objective evidence was provided by microscopic pyuria and hematuria, as well as positive urine cultures. In most cases, symptoms appeared soon after insertion or within a few months. Attacks of cystitis starting shortly after insertion of the IUD and continuing repetitively should arouse suspicion of bladder perforation, and concomitant absence of the IUD string or unanticipated pregnancy should heighten the suspicion. Preliminary investigation prior to cystoscopy is preferrable beginning with a plain X-ray film in anteroposterior (AP) and lateral projections. If a bladder calculus has not formed or is insufficiently radiopaque, the AP film can be misleading unless a lateral film is also taken. Although it was used in only 2 cases, sonography will probably prove increasingly valuable in the diagnosis of bladder perforations by IUDs. If sonography does not demonstrate the intravesical IUD, opacification of the bladder by intravenous pyelography or retrograde cystography, using AP and lateral films, may show it. Hysterography may be helpful when sonography or intravenous pyelography or retrograde cystography give a hint of concomitant partial uterine location of the IUD. Cystography after preliminary tests can help in planning the optimal approach for removing the IUD. In the 8 cases the free-floating IUD was removed by cystoscopy in 3 cases, the adherent IUD by suprapubic cystotomy in 4 cases, and by vaginal cystotomy in 1 case. In general, suprapubic cystotomy is the procedure of choice for removing an IUD perforating into and adherent to the bladder wall.
 ...
PMID:Perforation of the bladder by the intrauterine device. 622 4

Recurrence rate and symptoms after chemotherapy against acute uncomplicated cystitis (AUC) were studied. Upon completion of a 7-day treatment with two regimens, one of CEX alone (Group C) and the other of a combination of CEX with Lysozyme (Neuzym) (Group L), at a dose of 1 g CEX daily, efficacy of the drugs was assessed according to the criteria established by the UTI Study Group. The forty one cases in Group C and 38 cases in Group L showing an excellent response were evaluated for recurrence. The rates of recurrence were 12.2% in Group C and 21.1% in Group L during the first 7 days after treatment. In recurrent cases, bacteriuria was seen in 84.6% (11/13), pyuria in 53.8% (7/13) and miction pain in 30.8% (4/13). Thus, bacteriuria and pyuria should be the items of the criteria for AUC recurrence.
 ...
PMID:[Clinical studies on recurrence of acute uncomplicated cystitis]. 638 65

The authors review 70 patients with calyceal diverticula, 20 of these patients had an associated urological congenital malformation and 7 of them a lithiasis. The majority of these diverticula were discovered by chance but complications in the form of pain (26 cases), fever (11 cases) or macroscopic haematuria were the essential presenting symptoms. Clinical manifestations occur in relation to large diverticula and, in particular, those containing calculi. Patients with lithiasis are far more often infected than the others. The latent nature of diverticula is such that the onset of clinical symptoms and signs (lumbar pain, fever and pyuria) should lead to a search for an associated malformation, in particular vesico-ureteric reflux and direct cystography is essential. The virtually sole complication of a calyceal diverticulum is lithiasis. 43 of the 90 diverticula studied contained one or more calculi. Infectious complications may result from those diverticula containing stones and are rare in the absence of lithiasis. Only 18 patients underwent surgery (20 diverticula) : 9 by partial nephrectomy (polar in 9 cases and cuneiform in 2), 6 simple incisions of the diverticulum and 2 excisions of the diverticulum. In view of the rarity of complications, it is evident that only poorly tolerated diverticula require operation. In the view of the authors, two essential surgical techniques should be used : polar nephrectomy and resertion of the diverticular protrusion with closure of the neck. Finally, in the presence of associated vesico-ureteric reflux, it is the symptoms and signs of the latter which must influence the choice of treatment. When necessary, it would appear preferable to start by the correction of reflux.
 ...
PMID:[Calyceal diverticula : review of 80 diverticula in 70 patients (author's transl)]. 678 68

The chemistry, pharmacokinetics, pharmacology, clinical efficacy, adverse effects, physical dependence and tolerance, drug interactions, dosing, and cost of zomepirac sodium (Zomax, McNeil) are reviewed. Zomepirac is a new nonsteroidal anti-inflammatory agent (NSAIA) approved for the treatment of mild to moderately severe pain. The drug is well absorbed when given orally. It undergoes extensive biotransformation in the liver. Zomepirac shares the pharmacology of the other NSAIAs by decreasing prostaglandin synthesis. The efficacy of zomepirac has been demonstrated primarily in acute forms of pain with associated inflammatory processes including postdental-extraction, postpartum, and postoperative pain. Many of these studies have been single-dose evaluations. Zomepirac sodium 100 mg has been reported to be approximately equivalent to one to two tablets of aspirin-phenacetin-caffeine (APC) with codeine 30 mg. In two studies, zomepirac sodium 100 mg compared favorably with morphine sulfate 8 and 16 mg i.m. It has been shown to be superior to aspirin 650 mg in oral-surgery patients. In osteoarthritis, daily doses of zomepirac sodium 400-600 mg are approximately equivalent to aspirin 3200-4800 mg. Zomepirac has side effects similar to high-dose aspirin. Zomepirac is associated with an increased incidence of urogenital symptoms such as dysuria and pyuria. Because of tumorigenicity in rats, the drug is contraindicated in children, pregnant women, and nursing mothers. The drug has not demonstrated any potential for physical dependence, withdrawal, or tolerance. Zomepirac may provide a suitable alternative to aspirin, narcotic/NSAIA combinations, and narcotics in the treatment of mild to moderately severe pain. It is unlikely that zomepirac will replace narcotics in more severe types of pain.
 ...
PMID:Evaluation of zomepirac sodium. 702 15

The pediatric patient with acute scrotal pain and swelling can pose a difficult diagnostic problem. The therapeutic approach to these patients, however, need not be difficult. Despite the advent of Doppler ultrasonic equipment and technetium pertechnetate scanning to differentiate torsion of the testes from other causes of acute scrotal pain and swelling, the policy of emergency scrotal exploration in nearly all such pediatric patients seems to be most appropriate. The exception to this rule might be the rare child with frank pyuria and/or urinary tract infection in whom the diagnosis of epididymo-orchitis is suggested by all parameters.
 ...
PMID:Acute scrotal pain and swelling in children: a surgical emergency. 745 98

Chlamydia trachomatis (CT) and Escherichia coli (EC) antigens were sought in routinely prepared paraffin-embedded sections from 31 cases of acute and chronic epididymitis by indirect immunoperoxidase staining. Chlamydia trachomatis antigens were detected in epithelial cells as cytoplasmic inclusions in samples from six patients (mean age, 43 years) with severe epididymitis, characterized by minimally destructive, periductal, and intraepithelial inflammation with active epithelial proliferation. Squamous metaplasia and formation of lymphoepithelial complexes occasionally were noted. Escherichia coli antigens, common to other pyogenic bacteria, were observed in the cytoplasm of foamy histiocytes in samples from seven patients (mean age, 60 years), characterized by highly destructive epididymitis forming large abscesses and xanthogranulomas. Specimens from 18 patients were negative for either antigen. Pre-embedding immunoelectron microscopy on paraffin-embedded sections demonstrated positive reactions on the cell wall of the chlamydial bodies and rod-shaped bacteria. Escherichia coli-positive cases were accompanied by scrotal pain, pyuria, positive bacterial culture, leukocytosis, accelerated erythrocyte sedimentation rate, and a positive C-reactive protein test. Chlamydia trachomatis-positive cases were clinically indolent and manifested by an epididymal tumor. Chlamydial epididymitis can be distinguished from bacterial epididymitis not only clinically and immunohistochemically but also histologically.
 ...
PMID:Histological differentiation between chlamydial and bacterial epididymitis: nondestructive and proliferative versus destructive and abscess forming--immunohistochemical and clinicopathological findings. 770 19

Female acute uncomplicated cystitis responds relatively well to antimicrobial chemotherapy, but this is also a disease which shows a high frequency of recurrence. However, there have been no published reports regarding long-term monitoring of the course of this disease after therapy has been administered. Accordingly, using primarily a questionnaire, the authors carried out long-term monitoring (for a mean of 242 days) of the natural course of cases of female acute uncomplicated cystitis after single-dose therapy with lomefloxacin (LFLX), a new quinolone antimicrobial agent. The subjects of this study were female patients diagnosed as having acute uncomplicated cystitis with pain upon urination, pyuria (> or = 10 WBCs/hpf) and bacteriuria (> or = 10(4) cfu/ml). LFLX was orally administered as a single dose of 100 mg or 300 mg, and the therapeutic efficacy was evaluated on the 3rd and 7th days thereafter. In principle, the evaluation of cure was performed on the 7th day after LFLX administration, and monitoring was conducted to detect early recurrence during the next 7 days (i.e., through the 14th day after treatment). Then the subjects were monitored for late recurrence during a mean follow-up period of 242 days by means of a questionnaire. Confirmation of recurrence was carried out to the greatest extent possible. It was possible to carry out long-term monitoring of the natural course of 101 cases of female acute uncomplicated cystitis in which the clinical efficacy on the 3rd day after LFLX treatment had been evaluated as good or excellent.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:[Long-term monitoring of female acute uncomplicated cystitis cases after lomefloxacin single-dose therapy]. 775 34


<< Previous 1 2 3 4 5 6 Next >>