Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Different types of mechanical and spermicidal contraceptives are discussed. Condoms prevent the spread of venereal disease and retard premature ejaculation, but sometimes cause allergic reactions and break relatively often. Cervical caps, rings, and diaphragms are manufactured in diffferent sizes and differ in shape to accommodate different anatomical configurations. IUDs also are produced in many different shapes and sizes; some are coated with copper. IUDs accelerate the movement of the ovum through the Fallopian tubes and modify the development of the endometrium. IUD use can cause bleeding, pain, or uterine perforations. Their rate of effectiveness is between .4% and 5.3%, depending on the model; copper IUDs are the most effective. Spermicides are found in the form of cremes, jellies, and soluble suppositories.
 ...
PMID:[Contraceptive aids]. 103 2

The aim of the regional administration of opioids is to provide an efficient and prolonged analgesia. Then, opiates can be useful for postoperative analgesia and for the treatment of chronic pain of malignant origin. Analgesia is correlated with several adverse effects of which the most frequent are nausea and itching and the most severe is respiratory depression. Beside the adverse effects, other properties of opiates could be responsible of favourable effects which can be taken in advantage in specific indications. In the postoperative period, epidurally administered opioid can attenuate the neuroendocrine and metabolic responses to surgery and pain. This effect is responsible of a reduction of the resistance to insulin and of a better nutritional balance, especially after major abdominal surgical procedures. Opioids also act by a reduction of the motor functions of the bowel, which perhaps could reduce the incidence of anastomotic breakdowns. Finally, other effects have been reported, as anecdotes, such as the treatment of spasm after bilateral replantation of the ureters, neurologic bladder dysfunctions and enuresis. Spinal administration of opioids has also been used as a treatment of premature ejaculation.
 ...
PMID:[Non-analgesic effects of opioids]. 167 72

In order to explore the sexual problems of chronic schizophrenics, 51 cases were investigated. The result showed that 42 cases (82.3%) had various kinds of sexual problems. The problems were erectile impotence, frigidity, premature ejaculation, no ejaculation, vaginismus and pain on coitus. Only 4 cases had increased sexual desire. The authors found that the main sexual problems of chronic schizophrenics were inhibited sexual desire and excitement. The authors suggested that the sexual problems of chronic schizophrenics were related to their conditions in the body, rapport with their wives or husbands and the severity of affect, thought and volition disturbances.
 ...
PMID:[A pilot study of sexual problems in chronic schizophrenia: a report on 51 cases]. 263 98

The clinical features of psychogenic post-ejaculatory pain are described and some hypotheses regarding the etiology of this rare, distressing sexual disorder of men are offered. The source of the pain appears to involve the involuntary spasm of certain muscles of the male genitalia, which can be triggered by a variety of psychosexual conflicts. The syndrome of post-ejaculatory pain is considered within a continuum of psychogenic ejaculatory disorders, which range from the most severe impairment--retarded ejaculation (RE)--to the mildest--premature ejaculation (PE).
 ...
PMID:Post-ejaculatory pain syndrome. 833 48

Modern pharmacological treatment of impotence is determined by the presenting symptoms. Since this involves symptomatology with a heterogenous aetiology, many different drugs are involved in the treatment of impotence. Drugs used for libido and arousal problems include testosterone, yohimbine, trazodone and apomorphine. Since patient self-assessment is the only parameter that can be used to measure the result of treatment and positive results are seldom affirmed, no positive benefit of these agents can be assumed at present. Oral medications for erectile dysfunction include yohimbine, trazodone, apomorphine, phentolamine, arginine and sildenafil. Of these drugs, sildenafil has been the most systematically studied for effectiveness, but long term safety data await the results of post-marketing surveillance. Of the ejaculation disorder therapies, treatments for premature ejaculation are the best studied. Favourable results have been obtained with clomipramine, paroxetine and fluoxetine. The safety of these medications has been assessed through their long term use in psychiatry. Intracavernous self-injections for erectile disorders are performed using a variety of drugs and drug mixtures. Only alprostadil and the combination of papaverine with phentolamine are widely used. Alprostadil is very well tolerated; however, penile pain is a serious problem in a significant proportion of patients. Papaverine in combination with phentolamine is effective, but penile fibrosis and priapism occur more often than with the use of alprostadil. Several new developments in this area are currently under way. Alternative routes for medication for erectile dysfunction include ointments and patches to the penile skin and the glans. Only transurethral alprostadil, 'MUSE' (medicated urethral system for erection) has been shown to be effective in large trials. Long term safety still has to be demonstrated, but the 1-year safety profile is encouraging. In general, the end points of impotence treatment studies are very diverse so efficacy data can only be assessed in comparative studies. However, long term comparison studies have not been performed. Safety demands must be set very high for this type of treatment since the disorders being treated present no threat to the patient's health.
 ...
PMID:Comparative tolerability and efficacy of treatments for impotence. 1008 71

Sexual dysfunctions are highly prevalent, affecting about 43% of women and 31% of men. Hypoactive sexual desire disorder has been reported in approximately 30% of women and 15% of men in population-based studies, and is associated with a wide variety of medical and psychologic causes. Sexual arousal disorders, including erectile dysfunction in men and female sexual arousal disorder in women, are found in 10% to 20% of men and women, and is strongly age-related in men. Orgasmic disorder is relatively common in women, affecting about 10% to 15% in community-based studies. In contrast, premature ejaculation is the most common sexual complaint of men, with a reporting rate of approximately 30% in most studies. Finally, sexual pain disorders have been reported in 10% to 15% of women and less than 5% of men. In addition to their widespread prevalence, sexual dysfunctions have been found to impact significantly on interpersonal functioning and overall quality of life in both men and women.
 ...
PMID:Prevalence and risk factors of sexual dysfunction in men and women. 1112 54

In India, where there is widespread ignorance about sexuality and a resistance to its open discussion, sexual and reproductive health issues must be integrated into family planning programs. It is not possible for staff to discuss birth spacing with clients without also addressing the sexual context. Sexual problems that are an appropriate focus for family planning programs include difficulty achieving orgasm, pain on intercourse, vaginismus, impotence, premature ejaculation, and loss of libido. An integrated program is especially necessary in Asian countries given women's hesitation to raise sexual issues. Family planning staff have been shaped by the same cultural taboos and must be helped, through training, to adopt an open, positive attitude toward human sexuality. This openness must extend to unmarried young people as well.
 ...
PMID:Family planning encompasses sexuality -- an Asian perspective. 1234 76

Selective serotonin reuptake inhibitors (SSRIs) are widely used because of their safety, tolerability, and demonstrated efficacy across a broad range of clinical conditions. Medical literature supports the use of SSRIs for the treatment of many conditions outside of the indications approved by the U.S. Food and Drug Administration. SSRIs offer a reasonable alternative to traditional therapy for generalized anxiety disorder. A side effect of SSRIs coincidentally provides therapy for premature ejaculation. SSRIs may reduce the frequency and severity of migraine headaches and are possibly effective in reducing the pain of diabetic neuropathy. When taken in combination with tricyclic antidepressants, SSRis offer more potent therapy for fibromyalgia than either agent alone. SSRIs appear to be effective in some patients with neurocardiogenic syncope that is refractory to standard therapies. Clinical experience supported by ongoing research continues to expand on the broad array of therapeutic applications for this class of medication.
 ...
PMID:Off-label applications for SSRIs. 1566 23

A total of 298 randomly selected married couple dyads in rural China were studied. Sexual dysfunction (SD) was reported by 84 (28.2%) of the husbands and 136 (45.6%) of the wives. Co-occurrence of SD was reported by 51 of the married couples; hence, SD co-occurred in the spouses of 60.7% of the husbands with SD and 37.5% of wives reporting SD. Pain during intercourse but not other SD of the wives was associated with SD of the husbands. Men's SD including inability to achieve orgasm, finding sex not pleasurable and lack of interest in sex, but not premature ejaculation or erectile dysfunction, were associated with the presence of SD among the wives. Decision-making control on sexual matters, communication between the spouses on sexual problems, the seeking of professional help, perceived adequacy of sexual knowledge as well as mental health and vitality quality of life indices were associated with co-occurrence of SD within the couple dyads.
 ...
PMID:Co-occurrence of sexual dysfunction within young married couple dyads living in rural China: a population-based study. 1607 98

Premature ejaculation (PE) is the most common sexual problem experienced by men, and it affects 20%-30% of them. Pulsed radiofrequency (PRF) neuromodulation has been shown to be an effective treatment for a wide range of pain conditions. We used PRF to treat PE by desensitizing dorsal penile nerves in patients resistant to conventional treatments. Fifteen patients with a lifelong history of PE, defined as an intravaginal ejaculatory latency time (IELT) of <1 minute that occurred in more than 90% of acts of intercourse and was resistant to conventional treatments, were enrolled in this study. Patients with erectile dysfunction were excluded. The mean age of the patients was 39 +/- 9 years. Before and 3 weeks after the treatment, IELT and sexual satisfaction score (SSS; for patients and their partners) were obtained. The mean IELTs before and 3 weeks after procedure were 18.5 +/- 17.9 and 139.9 +/- 55.1 seconds, respectively. Side effects did not occur. Mean SSSs of patients before and after treatment were 1.3 +/- 0.3 and 4.6 +/- 0.5, and mean SSSs of partners before and after treatment were 1.3 +/- 0.4 and 4.4 +/- 0.5, respectively. In all cases, IELT and SSS were significantly increased (P < .05). None of the patients or their wives reported any treatment failure during the follow-up period. The mean follow-up time was 8.3 +/- 1.9 months. It is early to conclude that this new treatment modality might be used widely for the treatment of PE; however, because it is an innovative modality, placebo-controlled studies (eg, sham procedure), with larger numbers of patients and including assessment of penile sensitivity (eg, biothesiometry), are needed.
 ...
PMID:A novel treatment modality in patients with premature ejaculation resistant to conventional methods: the neuromodulation of dorsal penile nerves by pulsed radiofrequency. 1939 68


1 2 3 4 Next >>