Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The object of the study was to investigate the frequency of physiological sexual dysfunction in a population of men with spinal cord injury (SCI). A questionnaire-based survey of admissions during 1980-84 was undertaken at a regional spinal cord injury rehabilitation unit. Male patients aged 20-63 years with complete or incomplete tetraplegia or paraplegia living in their own homes were included in the study; 43 complied with inclusion criteria, and 38 answered the questionnaire. Ninety-five per cent of the patients stated that they could obtain an erection, 61% on a purely reflex basis; 66% stated that erection was sufficient for coitus, and 45% that they could obtain ejaculation/emission. More patients with incomplete than complete lesions reported ability to obtain ejaculation/emission. Significantly, more of the patients aged below 30 years reported erection sufficient for coitus (p less than 0.05). Forty-five per cent of the patients experienced complications of sexual activity, mainly in the form of bladder dysfunction and pain or spasms. In conclusion, SCI is usually accompanied by considerable sexual dysfunction, but most patients are still capable of functioning sexually. Thus, in the rehabilitation process after SCI, sexual counselling and information may be valuable.
 ...
PMID:Erectile and ejaculatory function of males with spinal cord injury. 263 May 55

Single extracellular action potentials have been recorded at 2 sites from human S4 ventral nerve roots, and their amplitude, duration and conduction time measured. Conduction velocity frequency distribution histograms have been constructed. Three classes of a-motoneurons could be identified, which had mean conduction velocity values of 61.5 (a1), 49 (a2) and 37.5 m/sec (a3) for a young adult at about 37 degrees C. The conduction velocity of single motor fibres has been correlated with its action potential amplitude and duration. The action potential amplitude increased and the duration decreased with the conduction velocity. Touch-stimulated and other afferences have been identified in these motor roots. The fastest afferents had about the same conduction velocity as the a1-motoneurons and the touch-stimulated afferents had conduction velocities of between 20 and 41 m/sec at about 34 degrees C. Also the amplitude of the afferent single unit potentials increased and the duration decreased with the conduction velocity. The electrophysiologically measured roots have been removed and morphologically analysed with the light and electron microscope. Nerve fibre diameter frequency distribution histograms have been constructed with respect to 4 myelin sheath thickness ranges. In the diameter histograms 3 a-motoneuron peaks with mean values of about 12.5 (a1), 10.3 (a2) and 8.3 microns (a3) and 1 peak of touch stimulated afferences with a mean value of 11.2 microns could be identified for myelin sheath thicknesses between 1.8 and 2.3 microns. A teased fibre dissection gave a factor of 100 between the internode length and the nerve fibre diameter. The electrophysiologic parameters have been correlated with the morphologic parameters. Approximate factors between the mean conduction velocities and the mean nerve fibre diameters of the a-motoneuron classes were 5.1 (a1), 4.85 (a2) and 4.4 m/sec/microns (a3) at about 37 degrees C. Comparable approximate conversion factors for group I and fastest touch-stimulated ventral root afferents were 4.5 (gr. I) and 3.5 m/sec/microns (touch). By comparing the number of nerve fibres of each class of motoneurons with the number of spontaneously occurring action potentials, it was found that the a3-motoneurons, most likely supplying the slow fatigue resistant muscle fibres, had the highest activation at rest. The existance of ventral root afferents has been discussed with respect to pain treatments by deafferentation and ventral root stimulation to improve the bladder function in paraplegia.(ABSTRACT TRUNCATED AT 400 WORDS)
 ...
PMID:Efferent and afferent fibres in human sacral ventral nerve roots: basic research and clinical implications. 264 71

The DREZ operation was first done in 1975 on a patient with arm pain following a brachial plexus avulsion. Since then approximately 500 patients have undergone the DREZ procedure under our care for treatment of various pain syndromes including deafferentation pain, post-herpetic neuralgia, and post-paraplegia pain. We report several modifications in instrumentation and technique. Currently, we use two types of electrodes for lesion production. The first is the standard 0.25 mm diameter, thermocouple, temperature monitoring electrode which has a 2 mm long tip for introduction into the spinal cord. A second type, recently modified from the original, is used only for lesioning the nucleus caudalis in patients with trigeminal post-herpetic neuralgia. Its tip is 3 mm long with insulation along the first 1 mm. This allows lesioning of the caudalis nucleus while sparing the more superficial spinocerebellar tracts. We no longer lesion only the dorsal root entry zones at each root level but include all the contiguous substantia gelatinosa between roots. With lesions only 1 mm apart this greatly increases the number of lesions and decreases the incidence of incomplete postoperative pain relief. In patients undergoing caudalis lesioning, we make two rows of lesions, one above the other, from C2 to slightly above the obex. This prevents sparing of the facial midline with resultant residual pain. Finally, lesions are made by heating the electrode tip to 75 degrees C for exactly 15 sec, thus allowing for a more uniform lesion. With these modifications, we have a decreased incidence of incomplete pain relief as well as a decreased incidence of complications, especially in patients undergoing caudalis lesioning.
 ...
PMID:The DREZ procedure: an update on technique. 269 14

During the last 10 years (1975-1985), a total of 18 cases of posttraumatic aneurysm at the level of the thoracic isthmus were operated on. Six of the 18 were women (19-71 years of age) and 12 were men (17-61 years of age). The mean age at the time of injury was, respectively, 22 and 25.8 years and, at the time of operation, 34.5 and 35.5 years. The patients were all involved in a motor vehicle accident, except for 2 (1 falling, 1 crushing). Thirty-nine percent of the patients had no apparent thoracic injury and 89% had associated injuries (bony fractures, craniofacial, visceral and abdominal). Eight of the 18 were asymptomatic at the time of operation, the others had various symptoms (pain, fever, dyspnea, cough, hoarseness, murmur, or hemoptysis). Enlargement of the aortic button was present in every case. Seventeen patients were operated on electively from 4 months to 50 years after the injury. Circumferential rupture was total in 9 patients and partial (2/3 to 9/10) in the others. Complete repair was done by either prosthetic Dacron tube (3), Dacron patch (2), or direct suture (12). Protection by femoro-femoral bypass was used in 3 and simple aortic cross-clamp was used in 14. Mean time of aortic cross-clamp was 36.9 minutes (range, 16-80 min). Among these 17 patients, there was no hospital mortality and no late death. One patient had regressive paraplegia. One patient was submitted to an emergency operation for an intrapulmonary rupture of an infected aneurysm and died in the operating room before completion of the repair.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Chronic traumatic aneurysms of the thoracic aorta. 272 61

Two patients with acute aortic thrombosis presented with painless paraplegia secondary to spinal cord infarction. In one case, the initial symptom was unilateral leg weakness, leading to the misdiagnosis of stroke. In the other case, a patient with a large, painful vulvar abscess, experienced spontaneous relief of pain. In the complete absence of pain, both patients slept undisturbed and awoke with complete paraplegia, incontinence, and cadaveric extremities. Aortic reconstruction was advised to obviate thigh or hindquarter amputation, not to restore limb function. One patient died on the second postoperative day; the second remains well but paraplegic two years later.
 ...
PMID:Acute aortic thrombosis presenting as painless paraplegia. 274 42

On the basis of previous experimental and clinical studies patients with severe spasticity due to spinal cord damage from multiple sclerosis in 8 cases and postraumatic paraplegia in 6 and resistent to all conservative treatments were selected for a trial with morphine and baclofen administered intrathecally through a catheter placed in the spinal subarachnoid space rostral to the affected segments and attached to a subcutaneous reservoir. Whereas morphine single injection did not show any benefit, baclofen bolus injection 30 to 60 micrograms, revealed a marked decrease of spasticity and associated symptoms in 8 cases. After checking the clinical effect during 3 weeks and changes in electroneurophysiological studies and bladder manometry the catheter was attached to a subcutaneous programmable pump able to be refilled percutaneously and administered baclofen continuously or more often following a multistep complex programme in total doses of 90 to 150 micrograms per day. After a mean follow-up of 5 months all cases showed an absence of spasms and pain, a notable improvement for bettering of sphincter functions and a marked muscle relaxation that improves motor capacity, leading to increased ambulation or mobility. Neither complications nor side-effects were observed.
 ...
PMID:Use of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity. 277 86

From April 1980 to August 1984, 11 cases of fracture--dislocation of spine at the level of T-11 to L-2 with obvious kyphosis at the site of displacement, with paraplegia, were treated by vertebrectomy through posterior median approach. The operations were performed 2 to 28 weeks, averaging 8 weeks, after injury. 5 of the 9 patients who had complete paraplegia suffered also causalgia in both legs. The other 2 had incomplete paraplegia only. Follow-up study, 4 years and 5 months post-operation on average, revealed complete reduction of the fracture-dislocation in 10 patients and incomplete in one, getting solid bony union in all. Concerning the neurological findings of the 9 complete paraplegic patients, 5, who had suffered from causalgia got varying degree of relief, 5 regained sensation of pain in region 2 segments lower, of the 2 incomplete paraplegic patients, 1 regained sensation of pain in both legs and muscular power of degree 4 in both thighs, so that walking became possible, while the another one fell into complete paraplegia, because of compression of the cord at T-10 happened during operation and showed no signs of recovery afterward.
 ...
PMID:[Vertebrectomy in treating fracture-dislocation of the spine with paraplegia]. 277 45

To determine the value of the usually given 'urgent' palliative radiotherapy in paraplegic patients with epidural compression from metastatic tumor, 20 consecutive cases treated between 1981 and 1986 were retrospectively analyzed. Bronchogenic and prostatic carcinoma were the more common extraspinal sources of metastasis. Epidural metastasis involved the thoracic spine in most cases. The onset of neurological symptomatology was frequently within two weeks prior to hospitalization. The majority of the subjects received at least 3000 cGy given in 10 to 15 fractions. Symptomatic (pain relief) response rate was 78 (7/9) percent. The observed period of survival averaged 2.5 months after treatment. This study reaffirmed the little chance for recovery of lost limb(s0 motor function. None of the patients (most of whom were paraplegic from two to 90 days pre-irradiation) became ambulatory including the two in whom irradiation was administered within 24 hours from the onset of paraplegia.
 ...
PMID:Epidural compression from metastatic tumor with resultant paralysis. 277 89

The hydatid disease is rare in osseous locations, especially in our country (2.2 per cent). It has some particularities: clinical latency, diagnosis difficulties, surgical treatment often unsatisfactory because of the difficulty of total excision. Pain and sometimes deformity are often the only clinical features at the beginning of the disease. But, the evolution is unfavourable as soon as neurological symptoms appear. Multiple recurrences lead to unavoidable paraplegia. The antihelminthic drug (mebendazole) is disappointing in osseous location. Surgery is the only hope but the excision must be carcinologic. Spinal instrumentation can be improved by the use of acrylic cement whereas osseous grafts can be invaded by hydatidosis extension or recurrence. At present, the prognosis is still poor with constant apparition of cord compression. The authors report two cases of patients with osseous hydatidosis of the spine which illustrate these difficulties.
 ...
PMID:[Vertebral hydatid cyst. Apropos of 2 cases]. 278 Oct 70

Single extracellular nerve action potentials from afferent fibres with various functions were recorded from human sacral nerve roots. It was shown that the potentials from these fibres can have different wave forms (amplitude, duration) and conduction velocities. The smaller potentials with longer durations have lower cut-off frequencies for certain identification than the larger potentials of shorter duration. The conduction velocity diagnosis covers a range of velocities with a factor of about 10. The slowest measured conduction velocities were between 4 and 10 m/sec. The identification of the functions of afferents in nerve roots is possible by calculating conduction velocities and stimulated activity increase measurements. Besides touch and pain fibres from the skin, afferents from mechano-receptors of the urinary bladder and the anal canal could be detected in dorsal sacral roots. There is evidence of motoneurons in the dorsal sacral roots supplying fatigue resistant muscle fibres. Sacral nerve root electrodiagnosis can be used in operations to identify physiologically-stimulated afferents and reflex activated motoneurons and, therefore, possibly will be useful in nerve anastomoses and nerve root stimulations in paraplegia.
 ...
PMID:Electrodiagnosis of human dorsal sacral nerve roots by recording afferent and efferent extracellular action potentials. 281 54


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>