Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Vaginal leiomyosarcoma is a very rare tumor. The authors report a case of primary presentation in a 51-year-old multipara who complained of the development, since about 12 months previously, of a vaginal swelling accompanied by bloody discharge and pain. The outcome was fatal twenty two months later following treatment combining chemotherapy, radiotherapy, and surgery. The case is discussed in the light of data from the literature.
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PMID:[A rare vaginal tumor: primary leiomyosarcoma. A case report]. 764 71

This is the 17th report on primary leiomyosarcoma of the liver in world literature. In 1980, a 69-year old white female patient was admitted with pain in the right upper abdomen and loss of weight of 12 kg. Increased blood sedimentation rate, elevated serum markers of the liver and ultrasound evolved a big tumor of the right liver without extrahepatic tumor nodules. Right hemihepatectomy was undertaken, the tumor was completely resected. After histologic examinations, leiomyosarcoma of the liver with 1 mitosis per 10 high power fields was diagnosed. 10 years later, the patient was readmitted with symptoms of pain, tiredness and night sweat. At this time, 3 intrahepatic and 1 retroperitoneal tumor nodules were detected. A sure-cut needle biopsy revealed the recurrent leiomyosarcoma with 4 mitoses per 10 high power fields. The survival period of 10+ years is the longest of all 17 patients with primary hepatic leiomyosarcoma reported so far. The low rate of mitoses per high power field and primary surgical resection are considered the reasons for the long survival period.
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PMID:Primary leiomyosarcoma of the liver--a case report. 768 May 13

Twelve patients with cavernous hemangiomas of the liver were treated by surgical resection from 1982 to 1991. There were three male and nine female patients. Their ages ranged from 31 to 62 with a mean of 49. All except one with gall bladder polyp had abdominal pain. Preoperatively, dynamic computerized tomographic scans performed on three patients produced accurate diagnoses, while angiography was correct in only 2 out of 7 patients. The indications for operation were suspected hepatoma in five, symptomatic pain in three, intraperitoneal hemorrhage resulting from biopsy in one, intrahepatic stone with suspicion of cholangioma in one, abdominal mass mimicking a gastric leiomyosarcoma in one and incidental laparotomy in a final patient. Surgical treatment resulted in no operative mortalities apart from one delayed death from cirrhotic decompensation occurring four months postoperatively. Morbidity included one patient with a postoperative hemorrhage and one with bile leakage, however, both of them were discharged uneventfully. During the follow up period from 6 to 72 months, no more abdominal pain attacked in those three patients with preoperative symptomatic pain. Three patients developed multiple recurrent hemangiomas. No identifiable causes were readily apparent. We conclude that the preoperative differentiation between hemangioma and hepatoma in a hepatic lesion is very important. When necessary, such as a giant symptomatic hemangioma of the liver can be safely resected without significant complications.
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PMID:Resectional therapy for a giant cavernous hemangioma of the liver. 785 Jun 47

Leiomyosarcoma of the colon is a rare tumor, with fewer than 45 cases being reported by 1980. Wide resection, 10 cm margin, and adjacent mesentery will decrease chances of locoregional relapse. We recently encountered two leiomyosarcomas in the colon in the past two years. One is a 63-year-old female who was seen with rectal bleeding, pain, and was found to have a large intraluminal leiomyosarcoma in the descending colon. Biopsy revealed leiomyosarcoma, grade III. She underwent a wide subtotal colectomy with ileosigmoid anastomosis, with metastases to three of the nodes in the mesentery, and remains well. The second is a 69-year-old female with general weakness who had previously undergone a hysterectomy and cholecystectomy. On examination she was found to have an abdominal mass. This proved to be a large leiomyosarcoma arising in the proximal portion of the transverse colon. There were no metastatic areas to the liver, chest, or any other areas. She has undergone extended right colectomy and remains well. Because of the rarity of this type of cancer, there is no established protocol concerning its treatment.
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PMID:Leiomyosarcoma of colon: report of two cases. 789 89

Tumors of the duodenum are relatively rare, accounting for about 1-2% of all gastrointestinal neoplasms. Nevertheless diagnosis and therapy are important, as 50% of all duodenal neoplasms are malignant. In the period 1987-1992 we treated 14 patients with duodenal neoplasms (11 men, 3 women, age 30-81 years [median 60.4]). 5 patients had undergone previous treatment for malignant tumors (4 genito-urinary tract, 1 rectum). The main symptoms were pain (43%), malaise (43%), weight loss (43%), anemia (28%), jaundice (28%), obstruction (22%), nausea and/or vomiting (22%). Diagnostic investigations were upper endoscopy (93%), computed tomography of the abdomen (72%), angiography or duplex-sonography (22%). Preoperative histology was malignant in 43%, benign in 22% and unclear in 35%. Surgery consisted of the following: duodenopancreatectomy (Whipple procedure) in 4 (31%), segmental resection in 2 (15%), local resection in 2 (15%), transduodenal excision of the ampulla of Vater in 1 (7.5%), modified Finney pyloroplasty in 1 (7.5%), gastroenterostomy in 2 (15%) and choledocho-jejunostomy in 1 (7.5%). One patient refused surgery or chemotherapy. The definitive histologies in the 13 operated cases were adeno-carcinoma in 8 (62%), leiomyosarcoma in 1 (8%), leiomyoma in 2 (15%), and tubulo-villous adenoma in 2 (15%). The tumors were located in pars I in 3 (22%), in pars II in 9 (64%) and in pars III in 2 (14%). There were no postoperative complications in 9 patients (70%). 2 patients had an abscess of the abdominal wall or multiple entero-cutaneous fistulas, and 2 patients died from multiple organ system failure. The 30-day mortality was 15.4% (2/13).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Duodenal tumors]. 793 16

A case of leiomyosarcoma of the prostate accompanied by multiple hepatocellular carcinoma in a 51-year-old man is presented. He visited our hospital with the complaints of feeling of residual urine and pain of the coccygeal bone in November, 1990. A histopathological study of the transrectal needle biopsy specimens revealed leiomyosarcoma of the prostate. Since multiple liver tumors were pointed out, the patient was given combined chemotherapy (CYVADIC: cyclophosphamide, vincristine, adriamycin and DTIC). He died 1 year and 2 months after the initial diagnosis due to hepatic failure. The autopsy findings revealed that the histology of the liver tumors was hepatocellular carcinoma, and that the leiomyosarcoma of the prostate had directly invaded the wall of the urinary bladder and the rectum, but there was no obvious distant metastasis.
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PMID:[Leiomyosarcoma of the prostate accompanied by multiple hepatocellular carcinoma: report of a case]. 812 27

In a 58-year-old man, a leiomyosarcoma was found to be the cause of unclear thoracal pain on the right side. The initial diagnose was an embolus of the pulmonary artery. The MRI showed a suspicious area similar to an intravasal tumor.
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PMID:[Leiomyosarcoma of the pulmonary artery]. 867 22

Leiomyosarcoma arising from the ovarian vein is extremely rare: only one case was found in the literature. We report a case in a sixty-one-year-old woman who had unexplained attacks of pain in her left lower abdomen and flank for two years.
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PMID:Leiomyosarcoma of the ovarian vein: an unusual cause of severe abdominal and flank pain. 877 24

Malignant anal tumours are rare cancers but are particularly common in Switzerland, Poland and Brazil. Very little is known about this condition in the Chinese population. A retrospective study, covering an 11-year period, was performed. A total of 18 patients were treated at the Prince of Wales Hospital, Hong Kong. There were eight squamous cell carcinomas, seven adenocarcinomas and one each of adenosquamous carcinoma, malignant melanoma and leiomyosarcoma. Bleeding per rectum, with or without perianal pain, was the main presenting symptom. Abdominoperineal resection was the treatment modality used in most cases. Adenocarcinomas, seen mainly in males, accounted for about 39% of cases, a figure much higher than that published elsewhere. Another 44% of patients, predominantly females, had squamous cell carcinoma. None had a positive past history of sexually transmitted disease. The local prevalence of HPV infection is much lower than in the Western world, and the role of HPV in the oncogenesis of anal tumours in the Chinese population awaits elucidation.
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PMID:Malignant anal tumours in the Chinese population in Hong Kong. 885 40

A 53-year-old female visited our out-patient department complaining of right flank pain. Ultrasonography revealed a solid mass lesion in the lower pole of the right kidney and further evaluation was scheduled. A few days later, she suddenly felt pain at the abdominal enlarged mass. Computed tomographic (CT) scan revealed a huge retroperitoneal mass with heterogenous density. Spontaneous rupture of renal tumor was suspected and emergency nephrectomy was performed. The ruptured tumor was pale, elastic firm and invaded directly to the duodenum. Histopathological findings revealed fibrous cells with frequent nuclear mitosis. Smooth muscle actin was identified immunohistochemically. Therefore, the tumor was diagnosed as leiomyosarcoma. The patient died 2 months after operation due to perforation of the intestine.
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PMID:[A case of spontaneous rupture of renal leiomyosarcoma]. 888 67


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