Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

46 endometriotic patients were treated by the method of removing Blood Stasis and resolving Phlegm, softening and resolving the Lump (RBS-RP-SRL). The total effective rate was 91.3%. Among them, the effective rate of dysmenorrhea was 97.6%, that of anal tenesmic was 94.3%, that of intercourse pain 86.7%, and 86.7% diminished in size of mass or nodule, 6 of 10 infertility patients became pregnant. It was showed by the laboratory assay that the cases were in the abnormal condition of nail bed microcirculation and hemorheology, which could be significantly improved after treatment. The results revealed that it was effective in treating endometriosis with the method of RBS-RP-SRL.
 ...
PMID:[Clinical study of the treatment of endometriosis with traditional Chinese medicine]. 800 Feb 20

The physician is consulted because of pains in the testicles or enlarged or empty scrotum, and he is primarily challenged to eliminate a possible testicular tumor. He is also questioned about the possibility of a later impairment of fertility. If severe testicular pains prevail, it usually signifies an acute testicular twist, the appearance of which every physician should be familiar with because immediate action is important--possibly an attempt of manual retorsion should be made, and most often the immediate referral to a specialist is imperative--in order to maintain the functioning of the endangered testicle. The testicular twist causes sudden testicular pains, frequently while sleeping or during sportive activities. The pain spreads into the groin region and can even lead to symptoms of shock. Frequent consequences are the disturbance of spermatogenesis. Less frequent infectious causes for testicular pains may manifest themselves as epididymitis or concomitant orchitis (parotitis epidemica). The assessment of the success of a consequent anti-infectious treatment should consider the genital symptomatology as well. Varicocele occurs almost only in the left side of the scrotum. The spermatogenesis of the left testicle is consequently often disturbed. In infertile men the varicocele is about three times more frequent than in fertile ones. If varicocele is found in adolescents, in which case it is important to compare both sides of the scrotum, the indication for a preventive surgical treatment is always impending. This question, however, is seen controversially (physiological state of transition or disease with remaining defects). We see an indication for surgical treatment also in varicocele of the adolescent boy, and not only in proven infertility of the adult male.
 ...
PMID:[Andrological problems in adolescence]. 801 55

Deep endometriosis has been defined as endometriosis infiltrating deeper than 5 mm under the peritoneum. A model for the development and propagation of endometriosis is presented. Subtle and non-pigmented lesions are suggested to occur intermittently in all women. Infiltration occurs generally to a few millimeters of depth only, and these lesions become typical, burnt out lesions. In some 20% of women, severe endometriosis develops either as deeply infiltrating disease or as cystic ovarian disease. Arguments are given to consider deep endometriosis and cystic ovarian endometriosis as two specific entities of endometriotic disease. A possible causal relationship with dioxin pollution is discussed. Diagnosis of deep endometriosis is made by clinical examination and palpation during surgery. Clinical examination during menstruation and CA-125 concentrations in plasma are useful to help in the diagnosis of smaller deep lesions. Surgical excision can be carried out by laparoscopy, laparotomy or vaginally using sharp dissection, electrosurgery or with the use of a CO2 laser. Excision is the treatment of choice because of a high pregnancy rate, a complete cure of pain in most women, and a low recurrence rate. Medical treatment is probably less effective to treat infertility, but highly effective in relieving pelvic pain. Medical therapy, by luteinizing hormone-releasing hormone agonists, danazol, or gestrinone, also seems useful as a pretreatment for surgery. The choice of treatment will therefore depend on the local expertise with minimal invasive surgery, certainly if a first excision has been incomplete and pain symptoms recur.
 ...
PMID:Treatment of deeply infiltrating endometriosis. 803 9

This study investigated the psychological differences between gynecological clinic attenders with either pelvic pain or infertility, or with both pelvic pain and infertility both before and after laparoscopic investigation with concurrent treatment. Given the differing meaning attached to the procedure by these groups, it was hypothesized that infertility patients would be more anxious but with less evidence of psychopathology in comparison with the pain group prior to laparoscopic surgery. Postsurgery and in the short term, pain reduction was expected to be associated with decreased pathology for the pain group. Contrary to the hypotheses, pain patients obtained higher anxiety scores in comparison with the infertility group both pretreatment as well as post-treatment. The latter group's scores were comparable to normative data. Other results were generally in line with the hypotheses, pain reduction for both pain groups being associated with a reduction in psychopathology. Patients with pain plus infertility resembled pain patients at pretreatment, while at post-treatment, they bore a closer resemblance to infertility patients in their psychological profile. This was despite the fact that for both pain groups, pain relief was similar. This reinforces the notion that in the patient groups studied anxiety is associated with pain rather than with infertility.
 ...
PMID:Patients with chronic pelvic pain and/or infertility: psychological differences pre- and post-treatment. 803 88

Five hundred and nine Laparoscopic examinations performed between 1987-91, (147 procedures for evaluation of gynaecologic pelvic pain and 313 for infertility) revealed ectopic pregnancy (27%), twisted ovarian cyst (18%) and acute pelvic inflammatory disease (14%) in cases of acute gynaecologic pain, and endometriosis (17%) and chronic pelvic inflammatory disease (16%) in chronic pelvic pain. Adhesions (20%), tubal block (15%), endometriosis (9%) and polycystic ovary (7%) were common findings in cases of infertility. These data support the usefulness of this minimally invasive procedure in accurate diagnosis of gynaecological disorders and provides insight into the spectra of diseases seen in Pakistani women with pelvic pain and infertility.
 ...
PMID:Laparoscopic appraisal of infertility and pelvic pain in Pakistani women: a 5 years audit. 804 Sep 92

Female circumcision is practiced in 26 African countries, and it is estimated that at least 100 million women are circumcised. The mildest form is clitoridectomy and the more severe type is infibulation. Girls are commonly circumcised between the ages of 4 and 10 years. Since the operator is usually a nonprofessional without surgical experience, complications are common: hemorrhage and severe pain that can even result in shock and death. The most common long-term complication is the formation of dermoid cysts in the line of the scar. Childbirth adds other risks for infibulated women and vesicovaginal fistula is often the result. The attendant urinary incontinence leads to ostracism of these women. In sum, female circumcision is a major contributor to childhood and maternal mortality and morbidity in communities with poor health services. The physical complications add to the psychological trauma: many infibulated women have a syndrome of chronic anxiety and depression arising from their condition, intractable dysmenorrhea, and the fear of infertility. The psychological sequelae of immigrant women who live in societies where such practice is condemned is even worse and may need professional counseling to address their sexual identity and cultural identification. Tightly infibulated women require clinical intervention for deinfibulation in order to preclude serious maternal and fetal complications during childbirth. Reinfibulation is medically harmful and even though some women request it, health professionals who comply are ethically reprehensible. In Sweden a 1982 law makes all forms of female circumcision illegal, as does a law that was passed in the United Kingdom in 1985. In France several cases were brought against parents under child abuse laws for circumcising or attempting to circumcise their French-born daughters. In the United States a 1993 bill drafted by the Congressional Women's Caucus would make the practice illegal and fund a program to assist immigrant communities to deal with the problem.
 ...
PMID:Female circumcision as a public health issue. 805 82

Intrasacral ependymomas are rare, accounting for only a small fraction of primary sacral tumors. They are typically large at diagnosis, which is preceded by a long history of pain. We present a case discovered during investigation of infertility. MRI features of the myxopapillary subgroup are described.
 ...
PMID:Intrasacral myxopapillary ependymoma. 810

Recent comparative studies and developments in our understanding of the pathogenesis and pathophysiology of endometriosis have led to increasing doubts about whether it should always be considered a disease. Widespread use of laparoscopy for gynaecological investigation and treatment, recognition of non-pigmented lesions which are more active than classical implants, and the documentation of microscopic lesions in visually normal peritoneum, have all resulted in an increase in the frequency with which endometriosis is diagnosed. Recent studies suggest a prevalence of up to 80% in women complaining of infertility or pelvic pain, but also in up to 22% of fertile asymptomatic women undergoing sterilization. Perhaps it is a normal physiological variant, being present in such a high proportion of the population. Circumstantial evidence suggests this may be so, and the results with placebo treatment in controlled trials suggest that endometriosis is self-limiting and will regress or disappear spontaneously in 58% of women. The frequency and severity of symptoms which are often presumed to result from endometriosis do not correlate with the extent or site of lesions. Most women are pain-free. There is no dysmenorrhoea in up to 77%, no dyspareunia in up to 70%, and no pelvic pain at all in up to 61% of women with endometriosis. The pathophysiology of pain related to endometriosis is not understood. There is no medical or conservative surgical treatment that is wholly effective for symptom relief, and there is considerable placebo benefit. All treatments have risks or side-effects, and recurrent symptoms will develop in up to 45% of women within 5 years. For these reasons treatment should only be used where endometriosis fulfils the criteria of a disease, showing signs of progression with tissue damage or physiological disturbance. Asymptomatic endometriosis without tissue damage should not be considered a disease and should not be treated. Treatment of pain associated with minor endometriosis, or prophylactic treatment to prevent progression, must be regarded as empirical and not the specific requirement to control what is a questionable disease.
 ...
PMID:Is endometriosis a disease? 813 9

IUDs perforate the uterus between 0.012% and 0.29% of insertions. Differences in operative skill and training account for the variation. Expulsion rates for copper IUDs vary from 1.8% within 2 years to 5% within 36 months. The timing of insertion tends not to affect expulsion rates. Most IUD users face heavy menstrual loss. Users of progestogen- impregnated IUDs often experience scanty menstrual loss or amenorrhea. Pain and bleeding account for discontinuation in 11-19.6 of 100 nonmedicated IUD users/year and of 4.4-6.8 of 100 copper IUD users in the 1st year of use. Irritation and pressure cause endometrial changes (e.g., a local inflammatory cell response) in most IUD users. Progestogen IUDs effect progestogen-related changes, e.g., pseudodecidualization of the stroma. Other endometrial effects of IUDs are vascular congestion and blanching and edema. Nonspecific, noninfectious cervicitis is most common in women using copper and progestogen-releasing IUDs than in women using other contraception. Candida strains are more common in the vagina of IUD users than in controls (20% vs. 6%). 2.8-11.6% of cervical smears of IUD users with no predisposing factors show Actinomyces-like organisms. Even though some studies suggest that IUDs increase the risk of pelvic infection, the increase occurs only in the first few months after insertion. There is also an increase for women with multiple partners. Less than 1% of IUD users become pregnant. About 50% and 25% of these women experience spontaneous abortion, if the IUD is left in situ or immediately removed, respectively. IUD users are at increased risk of ectopic pregnancy (5- 7.8% of pregnancies). Copper IUDs have the lowest ectopic pregnancy risk, while the low dose progestogen IUDs have the highest. Assuming no pelvic infection, fertility returns after IUD removal (e.g., 96.7% become pregnant within 18 months). Nulligravida who have ever used an IUD are 2-2.6 times more likely to have primary tubal infertility than those who had never used an IUD.
 ...
PMID:The pathology of intra-uterine contraceptive devices. 816 13

Twenty-two middle-aged women (median age 44.5 years) with Turner's syndrome were interviewed about family background, social identity, emotional development, relations, female identity, sexuality and reactions to the diagnosis, to evaluate how the condition has affected their lives and coping style. During the years preceding the diagnosis and hormonal replacement therapy (HRT) they had often isolated themselves as they felt different from their peers. Ovarian failure and infertility, not the body height, were the major problems for most of the women. Infertility had affected the women very deeply and many felt depressed because of this. Adolescent behaviour, a feeling of chronic inferiority or a feeling of grief were different ways of coping with the situation. Median age at sexual debut was 19.5 years. Painful intercourse related to vaginal constriction and sore membranes was commonly reported. Most of the women had stopped HRT because of side-effects. Many of the problems experienced by the women could have been avoided if proper HRT had been administered in due time and on a long-term basis. This emphasizes the importance of regular contact with a gynecologist of special training and interest.
 ...
PMID:Life with Turner's syndrome--a psychosocial report from 22 middle-aged women. 821 84


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>