Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ten female infants were referred for symptomatic hemangiomas in the anogenital area. (One had had steroid treatment prior to consultation.) The natural history of these lesions is well known. Virtually all will spontaneously involute over a period of years. However, the lesions reported were particularly troublesome because of repeated ulcerations and subsequent pain. Prior treatment had been local wound care with antibiotic ointment and Telfa-type dressings. After referral from a family practitioner or pediatrician, argon laser treatment was performed in an outpatient setting. Eight of the 10 patients were treated with local anesthesia, and 2 had general anesthesia. All lesions healed in 1 to 5 weeks. No patients referred during this period were excluded from this series. All who received treatment were included. All the lesions involuted following treatment. In our estimation, the final result is identical to what may be expected after spontaneous involution of an ulcerated or infected hemangioma. The major difference is that involution occurred in a few weeks in laser-treated patients rather than a period of months or years. Ulcerated hemangiomas of the anogenital area have significant morbidity that can be efficiently avoided with the use of argon laser therapy. Lesions of the anogenital area have a strong predilection for females.
 ...
PMID:Ulcerated anogenital hemangioma of infancy. 201 94

We report a 54-year-old woman who revealed right hemiparesis and ataxia in her right extremities due to a lesion which was suggested to be cavernous hemangioma located in the left side of pons in 1971, and showed remarkable crossed cerebellar atrophy (CCA) by computed tomography and magnetic resonance imaging in 1985 and 1989. Angiography showed no abnormality but made iatrogenic embolism in left thalamus which developed severe pain in her right side. Single-photon-emission-computed-tomography (SPECT) with I123-IMP in 1989 showed reduction of right cerebellar hemispheric blood flow (crossed cerebellar diaschisis: CCD) and left cerebral hemispheric blood flow. Our case was thought to have revealed persisting CCD. Although there are many reports about CCD and CCA following cerebral damage, CCD and CCA due to brain stem lesion has not been described yet. This might be explained by the persisting functional depression of cerebro-ponto-cerebellar pathways at the pons' level by cavernous hemangioma. It was assumed that the left cortical hypometabolism was result from damage to thalamo-cortical pathways due to ipsilateral thalamic lesion.
 ...
PMID:[Crossed cerebellar diaschisis and crossed cerebellar atrophy in a patient with a lesion in brain stem]. 204 4

Hepatic haemangiomas are the most common benign tumours of the liver and commonly present as incidental findings on sonographic examination of the abdomen. Since little is known of the natural course of these tumours, we performed a clinical and sonographic follow up of 123 haemangioma patients. Our prospective study investigated clinical and sonographic findings in 158 haemangiomas for periods of 12 to 60 months. Ninety nine haemangiomas measured less than 2 cm and had an echogenic pattern; 40 were between 2 cm and 5 cm with a mainly echogenic structure; 19 measured greater than 5 cm and showed a mixed echo pattern. At the first examination only eight patients, all with giant haemangiomas, presented symptoms which could be attributed to the tumour. During follow up only one haemangioma changed in shape and size. One patient who was symptom free at the first examination experienced right upper abdominal quadrant pain during follow up. No deterioration occurred in any of the patients with symptoms at the first examination, and all had a satisfactory quality of life. No complications arose during the follow up period. This study shows that in adults haemangiomas remain stable in size and echo patterns rarely change. Only haemangiomas greater than 5 cm may cause symptoms. Prolonged clinical and sonographic follow up of small and medium sized haemangiomas is not warranted.
 ...
PMID:Natural history of hepatic haemangiomas: clinical and ultrasound study. 206 Aug 77

A 33-year-old man was hospitalized for hyperpyrexia and pain in the left upper quadrant of his abdomen. Abdominal ultrasound showed a mass in the inferior pole of the spleen. A computed axial tomography of the abdomen and a liver and spleen scintigraphy confirmed a space-occupying lesion in the spleen but were not able to define its nature. A FNAB performed during abdominal ultrasound showed cells with elliptic nuclei and elongated pale blue cytoplasm, separated from each other by empty spaces of varying width. The presence of a hemangioma or lymphangioma of the spleen was suspected. A splenectomy was performed. The histologic findings were compatible with a cavernous hemangioma. After a review of the literature, the role of FNAB of the spleen is discussed as a reasonable diagnostic approach that assists the clinician in making therapeutic decisions in the management of the space-occupying lesions in the spleen. The possibility of differentiating benign from malignant lesions is pointed out, particularly those of endothelial nature. Finally, the differential diagnosis between hamartoma and hemangioma of the spleen is discussed. The two words, in times past, were often used for the same lesion, producing a confusion of names in literature.
 ...
PMID:Fine needle aspiration biopsy of a splenic hemangioma. A case report with review of the literature. 222 26

Intramuscular haemangioma, though benign, may be a serious disorder, because its large size can cause functional impairment, pain and disfigurement, which may require surgical excision. These, as well as the baffling histopathological aspects, are exemplified by this report of an intramuscular haemangioma of the forearm in an adolescent girl. Clinical recognition of a cutaneous angioma overlying a deeply-situated soft tissue tumour may aid the diagnosis of an intramuscular haemangioma.
 ...
PMID:Intramuscular haemangioma of the forearm. 223 May 8

An 18-month-old boy was admitted in April, 1988 because of a penile mass which had been first noted at the age of one month. From nine months after birth, transient bleeding from the mass accompanied by pain had been occasionally noted. At the age of 14 months, the mass seemed to grow markedly. On physical examination, there was an irregularly shaped mass on the right side of the prepuce. It was palpated subcutaneously, soft in consistency and was 10 mm in diameter. It had a light-purple color. Upon surgery, the mass was found not to have originated from the cavernous body of the penis, so that it could be excised without difficulty. Histopathological diagnosis was cavernous hemangioma. Electron microscopic examination revealed findings suggestive of newly formed blood vessels such as abnormal cuboidal shape of endothelial cells and a high nucleocytoplasmic ratio. Immunohistochemical examination of factor VIII-related antigen was in homogeneously positive in vascular endothelial cells. To our knowledge, this is the twenty-eighth case reported in Japan.
 ...
PMID:[Cavernous hemangioma of the penis: report of a case immunohistochemically studied]. 223 17

Vertebral haemangiomas are slowly growing benign tumours and are usually asymptomatic. They rarely cause symptoms and signs related to cord compression. Larger lesions create significant problems during surgery because of haemorrhage and vascular supply crucial to spinal cord function. In such severely symptomatic vertebral haemangiomas, radiation therapy has been tried and good results obtained, especially in terms of good functional recovery. We have treated 17 patients (including nine paraplegic patients) with radiotherapy (Co-60). Treatment was given by single posterior field, encompassing the involved area with a dose of 35-40 Gy in 3 to 4 weeks (five fractions per week). All patients with pain and tenderness were relieved completely (87.5%) or partially (12.5%). Similarly patients with numbness and paresis showed either complete (66.7%) or partial response (33.3%) from symptoms on follow-up. Out of nine paraplegic patients six (66.6%) had recovered completely, one (11.2%) partially and two (22.2%) had no response. The two patients who did not show any marked relief, had paraplegia of longer duration (more than 6 months). Our study indicates that severely symptomatic vertebral haemangioma can be successfully treated by radiation therapy and it can be chosen as first line of treatment with an optimum dose of 35-40 Gy in 3 to 4 weeks.
 ...
PMID:Radiation therapy for symptomatic vertebral haemangioma. 226 5

From February 1972 to December 1988, 80 cases of spinal tumor were treated in this hospital. 37 of these cases were primary tumor and 43 cases were secondary tumor. Most of the primary tumors were angioma and massive osteolysis, most of the metastatic tumors were from gastrointestinal and pulmonary carcinoma. The time of onset in both groups within half a year were 54.2% and 65.1% respectively. The dominant symptoms were pain, mass and paralysis. Except 4 cases which involved more than one vertebrae, all others involved only one vertebra. Primary tumours were mostly found in the sacrum (41.1%) and metastatic tumors were mostly found in the thoracic spine (65.2%). Sixty-three patients were treated by different combinations of operative methods. Eleven primary malignant tumor and 16 metastatic case had been followed-up for 3 months to 3 years, 25 cases died. The rate of misdiagnosis was 21.25%, which mainly occurred in the secondary group. The causes of misdiagnosis were analysed.
 ...
PMID:[Tumors of the spine: a clinical study of 80 cases]. 226 40

A synovial hemangioma in the knee joint of a 33-year old woman was diagnosed and removed arthroscopically. Preoperatively, this rare benign soft tissue lesion had caused recurrent swelling of the knee along with persistent pain and occasional buckling. Two years after surgery, the patient has a painless range of motion with no evidence of recurrence.
 ...
PMID:Arthroscopic excision of synovial hemangioma of the knee. 231 Apr 54

A case was presented in which a 28-year-old male presented with tenderness and stiffness in the posterior muscle group of his right leg. The patient's symptoms had been present intermittently for nearly 23 years. Recently, the pain had progressed to the point of limiting his normal daily activities. Initial conservative therapy, which consisted of Zorprin, heel lifts, and low Dye strapping, failed to alleviate the symptoms. Magnetic resonance imaging was used to identify a mass of an unknown etiology. Following orthopedic and oncologic consultation, surgical excision was advised and performed. Pathologic examination of the mass confirmed that the tumor was an intramuscular hemangioma. Classically, with intramuscular hemangiomas, patients may have soft tissue complaints, such as pain and swelling, present for years. Patients usually defer medical attention until the primary symptom of pain occurs. When a patient complains of a painful soft tissue mass of the leg, and intramuscular hemangioma should be included in the differential diagnosis. The appropriate radiographic studies and consultations should be performed, and surgical excision should be carried out.
 ...
PMID:Intramuscular hemangioma. Case report and literature review. 237 35


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>