Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A White glaucoma pump-shunt was inserted in 16 eyes in 15 patients, 2 to 76 years of age (10 female and 5 male patients; 6 were white, 6 were black, and 3 were Hispanic). Six had primary open-angle glaucoma, 2 glaucoma in aphakia, 1 congenital glaucoma, 4 secondary glaucoma, 2 neovascular glaucoma, and 1 glaucoma in pseudophakia. There were no complete successes. There were five (31.3%) "qualified successes" (ie, an intraocular pressure less than or equal to 21 mm Hg on medical treatment, without pain, and without visual acuity loss of more than two Snellen lines). This qualified success rate is far below rates reported for other setons.
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PMID:Long-term results with the White glaucoma pump-shunt. 225 Aug 82

33 patients (37 eyes) of neovascular and non-neovascular glaucoma were treated with cyclocryotherapy and followed up for 3-67 months, averaging 25 months. The IOP was brought under 2.73 kPa (21 mmHg) in 57.1% of the neovascular and 33.3% of the non-neovascular glaucomatous eyes, with an overall average IOP drop of 3.07 kPa (23.1 mmHg). Pain was controlled in 86.7% of the eyes. Cyclocryotherapy appeared to be an effective procedure for cases of refractory glaucoma, particularly those of neovascular origin. The complications and their mechanism were also discussed.
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PMID:[Cyclocryotherapy in the treatment of glaucoma]. 239 Sep 6

Six patients were treated for neovascular glaucoma by pan-retinal photocoagulation followed by trabeculectomy. Control of intraocular pressure and relief of pain were achieved in all patients. Methods to improve the fundal view before laser are described and alternative methods of therapy are briefly discussed.
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PMID:Recent experience in the management of neovascular glaucoma by pan-retinal photocoagulation and trabeculectomy. 244 96

A 44-year-old man had a blind painful right eye secondary to neovascular glaucoma. Cyclocryotherapy was performed because medical therapy was ineffective in lowering the intraocular pressure or reducing the pain. The eye became comfortable, but 5 months later vision decreased in the left eye. Examination revealed a marked posterior uveitis suggestive of sympathetic ophthalmia. Enucleation of the right eye and corticosteroid therapy were effective in eliminating inflammation in the left eye. Histopathologic examination of the exciting right eye revealed classic signs of sympathetic ophthalmia. This case is particularly unusual because there was no history or evidence of ocular perforation in the exciting eye.
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PMID:Choroiditis compatible with the histopathologic diagnosis of sympathetic ophthalmia following cyclocryotherapy of neovascular glaucoma. 335 83

This article describes the seventh published case of metastatic carcinoid to the choroid. Only two prior cases have been treated conservatively, one using chemotherapy and the other using photocoagulation and proton beam irradiation. Our patient was unique since she was the first to have conservative therapy by implantation of a radon ring. Initial results were clinically promising, although repeated ultrasound testing actually showed minimal decrease in tumor size. Subsequently, a large retinal detachment caused marked visual deterioration. Persistent pain from neovascular glaucoma prompted later enucleation, and silver staining as well as electron microscopic studies were performed on the choroidal lesion. It was found that the radon ring had little histologic effect on the viability of the tumor cells. This contrasted with an earlier report of the successful treatment of two much smaller choroidal lesions, using external proton beam irradiation. From our pathologic evaluation, we believe that the metastatic carcinoid tumor should be considered relatively radioresistant.
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PMID:Metastatic carcinoid to the choroid. 610 Nov 29

We treated 12 eyes with advanced neovascular glaucoma with a modification of drainage implant surgery. All 12 eyes had rubeosis iridis and severe pain and nine had undergone previous glaucoma surgery. After follow-up periods of two to 24 months (mean, 11.3 months), nine of 12 eyes had intraocular pressures of less than 24 mm Hg (mean preoperative value, 49.5 +/- 8.2 mm Hg; mean postoperative value, 22.2 +/- 12.9 mm Hg). Surgery was unsuccessful in three eyes, in two because the anterior chamber remained flat postoperatively and in one because a large hyphema blocked the tube 15 months postoperatively. Our procedure, which uses a Y-shaped Teflon tube, is easy to perform, is well tolerated by the eye, and is associated with a low risk of serious complications.
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PMID:Draining implant for neovascular glaucoma. 619 13

Sclera-laminating goniotrepanation is a modification of the Elliot-Fronimopoulos operation. In this procedure the scleral flap is removed, so that a shallow depression is formed in the sclera; this helps to prevent an ectatic bleb. No cicatrization of the trephine hole was observed in the authors' cases. The modification is only used by them in glaucoma cases with poor prognosis. Forty-six patients, 39 of whom were suffering from neovascular glaucoma associated with occlusion of the central retinal vein or diabetic retinopathy, underwent the operation and the results were followed up. As far as regulation of intraocular pressure and elimination of pain are concerned, the results were encouraging. Severe hemorrhage into the anterior chamber without spontaneous absorption only occurred in 2 cases.
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PMID:[Results of sclera-laminating goniotrephination in neovascular glaucoma]. 619 92

We operated on 59 eyes with advanced neovascular glaucoma (37 eyes in diabetic patients and 22 eyes in patients with central retinal vein occlusion) using a trabeculectomy technique that includes a simple silicone tube as the draining element. Mean (+/- 1 S.D.) intraocular pressure preoperatively was 57 +/- 8.7 mm Hg. During follow-up periods ranging from one to five years, the mean intraocular pressure decreased to 27 +/- 16.5 mm Hg. Adequate control of intraocular pressure (24 mm Hg or less) was achieved in 37 eyes (63%). Only four eyes required enucleation. Nine silicone tubes had to be removed because of necrosis of the scleral flap and conjunctival perforation or because they were expulsed. Surgery relieved the severe ocular pain even when intraocular pressure was not satisfactorily controlled.
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PMID:Long-term results of silicone tube in filtering surgery for eyes with neovascular glaucoma. 620 44

Three cases of neovascular glaucoma associated with ocular hypoperfusion secondary to carotid artery disease are reported. In two cases, anastomosis of the internal and external carotid artery systems via a superficial temporal artery to the middle cerebral artery (Yasargil procedure) resulted in resolution of the rubeosis, relief of the ocular pain and improvement of the circulation of the globe. The third case, which did not have this procedure, resulted in a blind eye with severe rubeotic glaucoma.
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PMID:Neovascular glaucoma associated with ocular hypoperfusion secondary to carotid artery disease. 620 4

A 44-year-old man had progressive visual loss and pain due to angle-closure glaucoma associated with a papillary pigmented lesion. The eye was enucleated because of intractable pain and the suspicion of a malignant tumor. Histologic and electron microscopic examination of the enucleated eye revealed a partially necrotic melanocytoma of the optic nerve. There was histologic evidence of vaso-occlusive disease within the optic nerve that resulted in ischemic necrosis of the tumor, hypoxic retinopathy and neovascular glaucoma. This report emphasizes that significant complications may occur in otherwise typical intraocular nevi.
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PMID:Angle closure glaucoma as initial manifestation of melanocytoma of the optic disc. 662 22


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