Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 9-year-old Latin American girl developed proptosis of the left eye associated with pain in the left ear of one month's duration. Ophthalmoscopic examination of the left eye disclosed retinal striae with venous tortuosity and papilledema. CT scan of the orbit showed a nonenhancing, irregular intraconal mass. CT scan of the brain demonstrated an enhancing left temporoparietal mass. Craniotomy revealed a 7 cm, extra-axial mass that was attached to the dura mater. Histologic examination, including a positive Leder stain, established the diagnosis of granulocytic sarcoma. At that time, the results of the laboratory studies, including complete cell blood count, were normal. Periodic clinical and hematologic evaluation was recommended. Twenty-five days after craniotomy, examination of the peripheral blood disclosed 56% myeloblasts and the bone marrow contained 30% blast cells. The problem in histologic differential diagnosis and a review of the literature is discussed.
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PMID:Granulocytic sarcoma of the orbit. A clinicopathologic study. 386 55

A case of subperiosteal orbital hemorrhage associated with chronic sinusitis is reported. A 57-year-old woman had a sudden onset of severe orbital pain and exophthalmos in the left eye. Computed tomography revealed a discrete round mass in the left retro-orbital space. An external frontoethmoidectomy was performed to evacuate the hematoma of the subperiosteal space. Additionally, the mucosa was edematous in the left ethmoid sinus. It appears that subperiosteal orbital hemorrhage in this case was caused by rupture of vessels which were inflamed as a result of sinusitis. Orbital hemorrhage associated with chronic sinusitis has rarely been reported. Diagnosis and treatment are discussed and etiologic factors are reviewed.
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PMID:Subperiosteal orbital hemorrhage associated with chronic sinusitis: a case report and review of the literature. 403 9

A 15-year-old female was evaluated for pain in the region of the right medial canthus and increasing exophthalmos. She had been diagnosed as having pseudo-tumor of the right orbit when she was 8 years old. The diagnosis was sustained until a second ophthalmologist requested a CT scan which demonstrated a mucocele of the right ethmoid sinus. Intranasal endoscopy revealed medial bulging of the right middle turbinate and meatus. Following a right external ethmoidectomy the eye returned to its normal position and pain disappeared. She has been asymptomatic for the past 4 years.
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PMID:Mucocele of the ethmoid sinus. 407 92

Iodide-induced thyrotoxicosis (IIT) occurs in patients with: 1) endemic goiter; 2) nonendemic goiter; 3) no previous thyroid disease. Iodine prophylaxis for endemic goiter caused transient increase of 0.01-0.04% over the basal incidence of hyperthyroidism peaking at 1-3 years and normalizing in 3-10 years despite continued iodide exposure. Elderly subjects with large nodular goiters of long standing are at greater risk. In nonendemic areas, iodine-containing drugs such as amiodarone, radiographic contrast media or iodochlorhydroxyquinoline are implicated in IIT more often than iodides. With nonendemic goiter, IIT occurs more commonly in women whereas, in the absence of preexisting thyroid disease, men are more often affected. In both groups, exophthalmos and antithyroid antibodies are absent, radioiodine uptake is low, there is no thyroid tenderness or pain, and the hyperthyroidism is self-limited (1-6 months) and should thus be treated conservatively. IIT occurs more frequently in areas of marginal iodine intake (Europe) than in the U.S. In view of the extensive exposure to iodine, it is a rare complication in this country. It is postulated that defective autoregulation of hormone biosynthesis may contribute to IIT.
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PMID:Iodide-induced thyrotoxicosis. 621 69

A 49-year-old black female presented with proptosis, orbital pain, decreased visual acuity, and a left frontal bone mass. This lesion resembled a meningioma by computerized tomography and carotid angiography. Following craniotomy, a tissue diagnosis was made of plasmacytoma, with systemic myeloma found by bone marrow biopsy. This case was unusual in its radiographic appearance as plasmacytomas are usually avascular. This case illustrates that orbital plasmacytomas may radiographically mimic other orbital tumors such as meningiomas, melanomas, and orbital carcinomas, and that definitive diagnosis must often depend on histopathologic study.
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PMID:Orbital involvement in multiple myeloma. A new angiographic presentation. 623 5

Orbital involvement is a rare complication of myeloma usually presenting as unilateral proptosis without pain. A case is reported of a woman with bilateral orbital infiltration without proptosis, who became blind within three months of the onset diplopia. The blindness was due to visual field obstruction, with eyelids covering both corneas; the eyes themselves remained normal. This is the first case of orbital myeloma reported in Australia and only the second case of bilateral primary orbital infiltration with myelomatosis to be reported in the world literature.
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PMID:Multiple myeloma with bilateral orbital infiltration and polyneuropathy. 625 77

A 36-year-old white man abruptly developed painless visual loss in his left eye. Fundoscopic evaluation revealed a shallow left superotemporal retinal detachment with an underlying yellowish choroidal infiltrate. Fluorescein angiography disclosed indistinct choroidal leakage, and both B-scan ultrasonography and computed tomography demonstrated superotemporal thickening of the choroid and the sclera. The patient was diagnosed clinically as having a scleritis and an associated exudative retinal detachment. He was placed on a several months' course of systemic prednisone, and despite this regimen, his condition worsened with the appearance of severe pain, proptosis and displacement of the eye, glaucoma, and intense episcleral and scleral injection. The eye was enucleated and displayed externally a massively thickened sclera superotemporally. Light microscopic evaluation of the enucleated globe revealed an extensively necrotic tumor growing diffusely within the choroid; infiltrating viable tumor cells were discovered within the sclera and episclera. The tumor cells had the characteristics of a well-differentiated, mucin-producing adenocarcinoma. Electron microscopic studies demonstrated lumen-forming tumor cells with apical villi, cytoplasmic pseudolumens, pools of cytoplasmic glycogen, and multiple types of inclusions, including mucin, lipid, and electron-dense secretory granules similar to those in pulmonary Clara cells. These findings were consistent with a bronchiolo-alveolar carcinoma. The patient subsequently developed bilateral reticulo-nodular pulmonary infiltrates, also typical of this tumor. The unusual clinical features of this case of "malignant scleritis" are discussed in light of the final diagnosis.
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PMID:Metastatic carcinoma masquerading as scleritis. 630 88

We treated a 40-year-old male who had orbital aspergillosis and presumed early intracranial extension with limited orbital exenteration and adjunctive amphotericin B. Forty-two months later the patient is alive without recurrence. Our patient illustrates the typical presentation of orbital aspergillosis with severe periorbital pain and proptosis; however, he did not have the usual concomitant sinusitis. Aggressive surgical and antifungal therapy in this case was successful in preventing further intracranial extension, which usually has a high mortality rate.
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PMID:Orbital aspergillosis. 634 37

Thirteen patients complained of recent fluctuating aching of one orbit, punctuated by stabbing pains. All had exquisite point tenderness over the trochlea and in half of the patients the pain was aggravated by eye movement. Standardized A-scan echography demonstrated swelling of the peritrochlear tissue and thickening of the superior oblique muscle with low internal acoustic reflectivity, typical of myositis. CT scan showed a soft tissue density in the region of the trochlea. Biopsy, performed on two patients, revealed peri-trochlear inflammation. In all patients the symptoms resolved within a period of weeks or months: indomethacin or naproxen were not effective, but oral or locally injected corticosteroids shortened the course compared to no treatment. None of the patients had ptosis, proptosis, Brown's syndrome, or a click, nor did they have echographic or radiographic signs of sinusitis or inflammation away from the trochlea. This probably represents a highly localized subtype of idiopathic orbital inflammation ("pseudotumor").
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PMID:Trochleitis with superior oblique myositis. 638 70

Two patients presented with unilateral peri-orbital pain, proptosis, chemosis and external ophthalmoplegia. They were shown to have dural arteriovenous fistulae related to the cavernous sinus. Intracerebral haemorrhage occurred in both patients within 18 months of presentation; this gave rise to focal seizures and signs of unilateral hemisphere dysfunction. The haematomas were in the region drained by the superficial middle cerebral vein ipsilateral to the shunt and are presumed to have been the result of locally raised venous pressure.
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PMID:Intracerebral haemorrhage complicating dural arteriovenous fistula: a report of two cases. 648 84


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