Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three hundred thirty-one cases of brucellosis included in a 10-year prospective protocol were reviewed to identify and follow up patients with spondylitis. Of 20 patients (17 male and three female; mean age, 54 years), spondylitis was diagnosed soon after onset of the brucellosis in 15, there were significant systemic symptoms in 17, and blood cultures were positive for Brucella melitensis in 14. The main symptom was vertebral pain. The commonest radiographic changes were narrowing of the disk and epiphysitis. The discrete character of radiographic alterations and negative uptake on bone scanning caused diagnostic delays in three patients. 99mTc bone scans finally became abnormal in all patients, but were not useful for follow-up because low uptake persisted after the clinical status stabilized. Three patients had paravertebral abscesses; in two of them fever and pain persisted despite antibiotic therapy until diagnosis and surgical drainage. Finally, all patients were cured, ten with sequelae. Brucellar spondylitis often had an acute clinical course with bacteremia. Because neither clinical nor radiographic changes one year after onset were significant, long-term follow-up is not considered necessary except when paravertebral abscess is suspected.
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PMID:Brucellar spondylitis: a detailed analysis based on current findings. 390 44

Twenty cases of calcaneal epiphysitis are reviewed. Six females and fourteen males presented with the complaint of heel pain which was bilateral in 80% of the cases. All patients were active in running-related sports. The mean age was 11.2 years (9-14) and symptoms had been present, on the average, for 5.5 months. Physical examination placed particular emphasis on the alignment of the leg and foot. Clinically the pain was localized to the insertion of the achilles tendon to the calcaneal epiphysis. Biomechanical evaluation revealed marked genu varus - 6 cases; forefoot varus - 10 cases. Treatment consisted of modified rest and ice massage - all cases; new shoes with medial support and rigid heel counters - 10 cases; heel lifts - 6 cases; soft orthotics - 15 cases; and semiflexible sporthotics - 2 cases. Response to the treatment was generally good with 75% of patients having a reduction in symptoms in 1 month and 95% by 3 months.
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PMID:Calcaneal epiphysitis in adolescent athletes. 729 46

Over 25 million children participate in school-sponsored sports, and an additional 20 million participate in extracurricular organized sports. Over the past decade, increased intensity of training, more pressure for success, new opportunities for structured play, and more organized advanced leagues and traveling teams have led to a corresponding increase in overuse injuries in the skeletally immature athlete. Perhaps the classic sports model for overuse injuries of the upper extremity is baseball. Throwing sports contribute to an increased incidence of elbow and shoulder injuries that might be related to intensity of training, throwing mechanics, and poor conditioning, including core strength. Specific areas of concern regarding overuse injuries in young athletes include such diagnoses as little leaguer's shoulder, little leaguer's elbow, osteochondritis dissecans of the elbow, tennis elbow, and distal radial epiphysitis. Ultimately, overuse injuries, and particularly physeal injuries, should be suspected in any young athlete who has pain in the upper extremity. Comparative bilateral radiographs are the rule in workup.
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PMID:Overuse and throwing injuries in the skeletally immature athlete. 1269 Aug 38