Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A mechanical noncoagulation obliterative technique - Falope ring or Silastic band - was used for laparoscopic tubal sterilization on 224 patients at the Brookdale Hospital Medical Center for July 1, 1976 through december 31, 1977. Hysterosalpingography under fluoroscopic guidance using Ethiodol was performed on 97 patients, 5-11 months after surgery, and observation laparoscopy was performed on 7 patients, 8-12 months after the initial operation. Tubal transection occurred 15 times in 12 of 224 patients (5.4%). Management included banding, coagulation, and both coagulation and banding. Pain requiring analgesia on the 1st postoperative day or requiring a prescribed analgesia at home was present in 14 patients (6.7%). Infection appeared as salpingitis-peritonitis in a patient whose IUD was removed immediately prior to banding. Pregnancy occurred in 2 patients. The incidence of complications was low.
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PMID:Silicone band sterilization with radiographic and laparoscopic evaluation. 15 20

Guinea worm infection is one of the most easily prevented parasitic diseases, but it is nevertheless a common cause of disability in rural areas of Africa, south-west Asia, and India. Infection occurs when drinking water is infested with infected Cyclops, a microcrustacean. Worms up to 70-80 cm in length develop in the subcutaneous tissues of the feet or legs and larvae are liberated to renew the cycle when an infected individual steps into a well or pond from which others draw drinking water. Infection is markedly seasonal because of (a) the influence of the climate on the types of water source used and (b) the developmental cycle of the parasite. The disability may be economically very important if the period of infection coincides with busy periods in the agricultural year. Sieving water through a cloth is sufficient to remove the Cyclops, but on a public health scale improved water supplies are required for control. Once the cycle of reinfection can be broken in any district the disease disappears. Chemical treatment of water bodies with temephos is also an effective and safe way of controlling transmission. Treatment consists of rolling out each emerging worm onto a small stick, a few centimetres each day, and certain drugs reduce the pain and pruritus and enable the worm to be removed more quickly.
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PMID:Guinea worm disease: epidemiology, control, and treatment. 16 22

Sisomicin, an aminoglycoside antibiotic, is especially effective against Escherichia coli, Klebsiella, Enterobacter, Citrobacter, Serratia, indole-positive and indole-negative Proteus species, Pseudomonas aeruginosa, Salmonella and Staphylococcus aureus. It has a bactericidal action. Although sisomicin is similar to the other aminoglycoside antibiotics, there is not complete cross-resistance to them. Our own pharmacokinetic investigations showed that a dose of 2--3 mg/kg body weight of sisomicin twice daily is necessary in the neonatal period. Infants should be given 2.5 mg/kg body weight three times daily, and school children 1.5--20 mg/kg body weight, likewise three times daily. Excretion of sisomicin in the urine is lower in children than in adults, amounting within 24 hours to only 10--20% in newborns, and 30--40% in school-children. Sisomicin induces excretion of some enzymes in higher quantities from the tubular part of the kidneys, especially alaninaminopeptidase. A report is given on 58 patients, especially newborns and prematures, who were treated for about seven days with sisomicin. The results obtained with a wide variety of infections (such as omphalitis, aspiration of amniotic fluid with broncho-pneumonia, phlegmons of the galea, and also pyelonephritis and mucoviscidosis with pulmonary complications) can be described as good, with a success rate of 85%. On only seven occasions were insignificant transitory side-effects, such as slight increase in transaminases, toxic-allergic exanthema and pain in the region in injection, observed.
Infection 1979
PMID:[Experience with sisomicin in pediatrics (author's transl)]. 38 23

One hundred sixty-five feet were reconstructed with the single stem silicone implant, including patients with hallux regidus, hallux valgus due to degenerative and osteoarthritic joint changes, hallux valgus secondary to rheumatoid arthritis and patients with previous unsuccessful "bunion" procedures. Preoperative pain and intolerance to shoe wear were relieved in the great majority of patients. The amount of correction of the hallux valgus angle was directly related to the preoperative deformity. Infection occurred in 2 patients, and inflammatory reaction to the implant occurred in one patient. One hundred five feet were reconstructed with a flexible hinge implant; 94 of the feet had joints destroyed by rheumatoid arthritis. Dramatic improvement in the hallux valgus angle resulted in these feet which had relatively severe preoperative deformities. No implant fractures were recorded. The present survey of our cases, and experiences reported by others, encourage the use of these implants by surgeons who follow the suggested indications, surgical technique, and follow up care.
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PMID:Silicone implant arthroplasty of the great toe. A review of single stem and flexible hinge implants. 38 24

Recently, IUd usage has increased, and with that increase has come an awareness of the undesirable side effects of the device, notably infection. Infection risks can be minimized if clinicians observe aseptic and sterile procedures. Histological studies were conducted on the tissues adhering to the IUDs of 244 women. The women were aged 20-40, and had had the IUD in place for an average of 4 years. Histological rather than bacteriological studies were conducted because the presence of bacteria does not necessarily indicate that disease is present. Secretory endometrium was found in 54.8% of the women, proliferative endometrium in 32.2%, cellular debris in 4.9% and stromoglandular disassociation in 8.1%. Of the 19 women in whom disease states were detected, endometritis chronica was seen in 79% of the cases, E. purulenta in 10.5%, e. acuta in 5.25% and E. subacuta in 5.25%. All of these conditions vanished after removal of the IUD and antibiotic treatment. In none of the cases was the IUD associated with precancerous atypia. Prevention may be the best approach with respect to infectuous complications associated with IUD use. Colposcopy, culturing of cervical mucus, PAP smears, erythrocyte sedimentation and leukocyte counts should be performed on women prior to IUD insertion. These steps guard against introducing vaginal infections into the uterus. When a woman comes to a physician complaining of pain in the lower back, abdomen, or during intercourse, infection must be suspected. If infection is found, treatment to eliminate the offending organism needs to be initiated. The woman's partner may also need to be treated.
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PMID:[Prolonged use of IUD and inflammatory diseases of the inner genitalia]. 44 93

The study is based on the analysis of 10 cases of sarcomatosis of the brain and spinal pia mater. A progressive development of the disease, cachaxia, the existence of focal symptoms, radicle pain, xantochromia in the CSF, protein-cell dissociation and some other signs are characteristic of primary sarcomatosis of the pia mater. On the basis of clinical symptoms and CSF changes it is possible vitaly to perform a differential diagnosis with chronic infectious diseases and especially with tubercular meningitis and polyradiculomyelitis. Pathomorphological studies revealed tissue infiltration of the surrounding intracerebral vessels by tumors cells without proliferation into the dura mater and radicles of the spinal cord.
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PMID:[Clinical picture and diagnosis of leptomeningeal sarcomatosis]. 86 22

Survey of methods. In first part new classification of prostheses. Discussion of some biomechanical problems, mainly on hinge-prosthesis which can only be compromises for various periods. Replacement to be considered only for elderly or very old patients, when conservative treatment offers no chances, other operations are not promising or have failed, arthrodeses cannot be done and pain and loss of function are severe. Indications for hinge- and slide-prostheses are given. In the second part two statistics of results from the literature are discussed and experience with 130 own cases using own model is described. Infection occurred in 3 cases where removal of prosthesis had to be done. Examples of the need for reversal operations are given.
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PMID:[Replacement of the knee-joint (author's transl)]. 93 Feb 42

Thirteen cases of anorectal Herpesivirus hominis infection in male homosexuals are described. Symptoms included pruitus ani in 11 cases, while 7 noticed intense and pain. Change of bowel habits and anal discharge were not presenting symptoms in the majority. None had generalized complications. Inguinal lymphadenopathy, a vesicular eruption, and superficial ulceration around the anal margin were commonly found. Some developed vesicular spread to the natal cleft. Treatment with cotrimoxazole to prevent masking of possible coexistent syphilis, though satisfactory in preventing secondary infection seemed to have little effect on early resolution of the lesions. Relapse occurred in over one third of the patients. Infection with Herpesvirus hominis seems an uncommon but increasingly recognized hazard for the passive homosexual and should be included in the differential diagnosis of lesions presenting at the anus.
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PMID:Anorectal Herpesvirus hominis infection in men. 101 Jul 70

Infection of the intervertebral space is a rare complication of operation on the disc (Ford and Key 1955). It occurred in five cases in a series of 650 operations for lumbar disc protrusion done by two of the authors of this paper--an incidence of 0-8%. Symptoms began between seven and twelve days after operation. After initial relief of the original sciatic pain, the patients developed severe back pain and muscle cramps in the legs. Straight-leg raising became much more limited than before operation. The erythrocyte sedimentation rate was raised in all cases. The diagnosis was confirmed by rescreening the Myodil, when an indentation was seen opposite the intervertebral space from which the disc had been excised. Early removal of infected material from the disc space resulted in complete relief of pain and cure of the infection.
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PMID:Infection of intervertebral discs after operation. 127 Apr 87

We reviewed the records of 17 cases of Fournier's gangrene that had been diagnosed and treated in the Urology Service of the Marques de Valdecilla Hospital from 1982-1991. The series comprised male patients aged 32 to 77. Eleven cases (64.7%) were due to a known cause, above all infection. Most of the patients had factors that predisposed to the development and progression of the disease, predominantly diabetes mellitus (5 cases, 29.4%). The clinical features frequently corresponded to those of acute infection, with high fever, chills, pain, nausea and vomiting that could progress to a septic state. The local symptoms and signs included pain, swelling, erythema and necrosis, depending on the compromised area. Infection was usually caused by Gram-negative bacteria, particularly E. coli, although Gram-positive bacteria and anaerobes have been observed. Mixed bacterial infections have also been observed. Treatment must be instituted early using a combination of broad spectrum antibiotics that cover both aerobes and anaerobes, and wide surgical debridement of the compromised area. In some cases hyperbaric oxygen therapy may be warranted. The disease continues to be severe. In the present series, the outcome was favorable in 12 cases (70.5%) and there were 5 deaths (29.4%).
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PMID:[Our caseload in Fournier's disease]. 129 42


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