Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The studied material comprised 15 men with 12 of them having the episodic from of Horton's headaches and 3 with chronic form. In the episodic form the age of the patients was from 32 to 48 years, mean age 38. The history of the disease was from 6 to 12 years, the duration of a spell of headaches was 2-3 months and the patients had then 2-5 attacks of pain daily. Before the onset of treatment the patients were not given for 1 week any drugs or placebo. After determination of the index of attacks treatment was begun. For 7-10 days the patients received daily intramuscular testosterone propionate 25 mg, and then 10 mg for a similar time period. Before the treatment the index of attacks was 3.66 (with the total number of attacks 308). In the first week of treatment it decreased to 1.11 (94 attacks), in the second week it was 0.16 and in the third week 0.05. In 10 patients the attacks disappeared completely (83%), in the remaining 2 ones they regressed in a later time. Three patients with the chronic form received this treatment without effect.
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PMID:[Treatment of Horton's headache with testosterone]. 383 88

Cocainization of the sphenopalatine fossa region has been shown to abort acute cluster headaches rapidly. Whether this response occurs by sympathomimetic action or via local anesthetic effect has been unknown. In this study, lidocaine hydrochloride was given as a therapeutic abortive agent to patients with cluster headache to elucidate cocaine's mechanism of action in relieving symptoms and to search for a safe, nonaddicting agent for self-administration. Using a 4% lidocaine solution applied to the sphenopalatine fossa, four of five patients obtained rapid relief of nitrate-induced cluster headaches and associated signs. Lidocaine was also effective in relieving spontaneous attacks. These results indicated that anesthetic rather than sympathomimetic effects are responsible for cocaine-medicated abortion of cluster headache, that transmission of pain in cluster headache likely occurs via the sphenopalatine fossa, and that topical lidocaine is effective in rapidly aborting acute cluster headache.
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PMID:Cluster headache. Local anesthetic abortive agents. 399 68

Chronic migrainous neuralgia is not diagnosed as often as the periodic or "cluster" form of Horton's syndrome. The distinguishing features of chronic migrainous neuralgia, compared with the periodic variety, are the frequency and persistence of the attacks of hemicraniofacial pain and the intractability to medical management. Eight male patients ranging in age from 22 to 45 years received prompt, although transient, pain relief by blockade of the Gasserian ganglion on the side of their hemifacial pain with a local anesthetic. Prolonged relief was subsequently achieved by percutaneous radiofrequency trigeminal ganglio-rhizolysis. There were no significant complications from this procedure. Review of the literature indicated that other ablative neurosurgical procedures, such as alcohol injection of the Gasserian ganglion and trigeminal rhizotomy by the subtemporal craniectomy approach, have relieved migrainous neuralgia, but with a greater risk and incidence of complications. The characteristic clinical features of migrainous neuralgia and the medical and surgical approaches to therapy are discussed.
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PMID:Surgical control of chronic migrainous neuralgia by trigeminal ganglio-rhizolysis. 618 Jan 52

Cluster headache and trigeminal neuralgia (tic douloureux) share a common pattern of exacerbation and remission of pain that is described in similar terms by patients. Although the treatment of these conditions is markedly different, the results of adequate prophylaxis can be extremely impressive in both. The physician who treats headache patients should be aware of the common characteristics of each condition and of the possibility of their concomitant occurrence.
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PMID:Cluster headache with trigeminal neuralgia. An uncommon association that may be more than coincidental. 642 Jul 83

Eleven patients were examined thermographically during spontaneous cluster headaches and 22 during attacks induced by nitroglycerin or alcohol. In cluster headache, heat loss increased from the affected orbital region, and in some patients, this spread above and below the eye, down the nose, and to the affected temple. Inhalation of 100% oxygen reduced or abolished cluster pain in 22 of 25 instances, and asymmetry of heat loss then disappeared. Since the unilateral increase in blood flow usually followed the onset of pain in affected areas, the vascular changes of cluster headache are probably secondary phenomena, initiated by a vasodilator pathway, with the trigeminal nerve as the afferent and the greater superficial petrosal nerve as the efferent limb.
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PMID:Thermographic changes in cluster headache. 654 1

Serum testosterone level was determined by radioimmunoassay in 57 men, including 23 cases of Horton's neuralgia during the period of recurrent headaches but not during an attack of headache, in 10 cases of trigeminal neuralgia, 10 cases of radicular pain and in 14 blood donors. Only in the blood donors this level was normal, in the remaining cases it was statistically significantly decreased, especially in cases of radicular pains. The author believes that in the period of Horton's headaches the testosterone level is decreased due to recurrent attacks of pain and not due to a process involving the hypothalamus.
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PMID:[Blood testosterone levels in patients with Horton's headache]. 664 28

Cluster headache remains a disease with almost totally unknown etiology and poorly understood pathogenesis. Some evidence has been presented to suggest that histamine released from mast cells might possibly be responsible for the initiation of pain attack. The authors present ultrastructural data concerning cutaneous mast cells in the painful region in patients suffering from cluster headache. The biopsies were taken between attacks in a bout. The fine structure of the mast cells (namely swollen granules, zones of decreased density, membrane-bound vesicles and granular fusion) are consistent with the dissolution pattern of secretion. The possible role of antidromic-reflex activation of the mast cells is also discussed.
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PMID:Mast cells in cluster headache. Ultrastructure, release pattern and possible pathogenetic significance. 673 78

Present views on the cause and treatment of temporal arteritis, trigeminal neuralgia, pain arising from the neck, benign intracranial hypertension, and other headaches of intracranial origin are summarized. The clinical components of migraine are correlated with recent studies of cerebral blood flow, monoamine changes, and the platelet release reaction. Psychological, physiological, and pharmacological management is based on the holistic concept of migraine as an uninhibited protective reaction. Cluster headache is subdivided into three varieties which respond preferentially to different medication. Tension headache may depend more on vascular mechanisms than excessive muscle contraction, but treatment is still directed at behavioral management and relaxation training with the aid of antidepressant therapy.
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PMID:Headache. 702 51

The skin of both temples was examined ultrastructurally in six patients with cluster headaches and in three controls. An increased number of mast cells were present in the patients irrespective of whether they were in a cluster period or in a quiescent phase. The mast cells were found perivascularly and in the vicinity of cutaneous nerves in the patients, whereas they were predominantly found in perivascular areas in controls. Mast cell degranulation was not more prominent on the side of the pain and occasional degranulated mast cells were found in controls. These findings are consistent with the hypothesis that cluster headache is due to an axonal reflex in the trigeminal system, initiated perhaps by latent viral infection of IgE activation of mast cells.
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PMID:Cluster headache. Ultrastructural aspects and pathogenetic mechanisms. 722 18

1. Cluster headache is a severe unilateral head or facial pain, which lasts for minutes or hours, commonly associated with ipsilateral lacrimation and blockade of the nostril. It usually recurres once or more daily for a period of weeks or months, separated by intervals of freedom. The sphenopalatine ganglion seems to play a very important role in its pathology, 2. We created a technic of alcohol infiltration of this ganglion through a supra-zygomatic way, based on the research of the maxillary nerve by neurostimulation and the bone contact with the pterygoid process. 3. We observed a relief of pain and parsympathetic disturbances in more than 85% of our 120 cases, with a follow up between 6 months and 4 years. 4. Results obtained are discussed and analysed in connection with the definition of cluster headache. (Acta anaesth. belg., 1981, 32, 101-107).
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PMID:Cluster headache and sphenopalatine block. 729 8


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