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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During a 23 year period at Memorial Hospital, the diagnosis of liver cell carcinoma was made in 42 patients who were 11 to 40 years old. Ninety per cent were Caucasian, mostly born in the United states. No occupational hazard was detected. Serum hepatitis antigen was demonstrated in only one patient. Alpha fetoprotein was found in the serum of 55 per cent of nine patients tested. Eight-three per cent were Rh positive, 43 per cent were ABO groups, A or O, respectively. Twenty-three per cent of 13 patients with sufficient material for study had an associated cirrhosis. Of these, active hepatitis with cirrhosis was present in one patient; postnecrotic cirrhosis was present in another. Approximately 7 per cent had a history of previous liver disease. One patient had infectious mononucleosis, and nearly 13 per cent gave a family history of cancer. Weight loss or pain in the right upper abdominal quadrant was present in 65 per cent, and hepatomegaly was found in 88 per cent. Only one patient presented with hemoperitoneum simulating an acute condition within abdomen. The liver profile examinations characteristically revealed an elevation in serum alkaline phosphatase, 5 nucleotidase, and Bromsulphalein retention with normal bilirubin level. The most common finding, upon roentgenographic examination, was an elevated right hemidiaphragm. Selective celiac and superior mesenteric angiography and 99mTc sulfur colloid liver scans were both done in 13 patients. There was a 75 per cent accuracy rate in localization of the tumor. At laparotomy, the tumor was found to be confined to one lobe in seven patients and involved both lobes in ten. Twenty-seven patients were thought to have multicentric tumors and 15 unicentric lesions. Only ten were found to be candidates for hepatic lobectomy. Five and ten years survival rates were 20 per cent; the operative mortality rate was 40 per cent. Twenty per cent died within a year, ten per cent, one patient, is alive with disease at 28 months and another is free of disease at 31-months. Paraneoplastic syndromes were erythrocytosis in two patients, terminal stage of hypoglycemia in one patient, and hypocholesterolemia with associated excess beta globulin in one patient.
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PMID:Liver cell carcinoma during the prime of life. 17 34

Benign tumors of the esophagus are rare and require an alert suspicion for early diagnosis. These tumors may not cause symtoms before attaining large size, yet they may prove fatal when small. Because of the possibility of malignancy and their tendency to obstruct, benign tumors of the esophagus should be resected when diagnosed. This report details our experience in 20 patients with benign esophageal tumors seen at Emory University Hospital between 1955 and 1975. There were 15 men and five women in the group, ranging in age from 17 to 75 years. The tumor series included 13 leiomyomas, four cysts, two cases of multiple polyps, and one case of granular cell myoblastoma. Six of the tumors were asymptomatic; the remaining 14 had symptoms of dysphagia, pain, and hematemesis. In one instance, episodic hematemesis and melena were so severe that they produced hemorrhagic shock. Characteristic radiologic features helped in making the preoperative diagnosis in 18 of the 20 cases. Two patients had coexisting disease masking the presence of the esophageal tumor. Seventeen patients had surgical resection. There were no operative deaths and follow-up results have been satisfactory.
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PMID:Benign tumors of the esophagus: experience with 20 cases. 19 36

Adenoidcystic carcinoma or cylindroma of the parotid gland is a slow-growing, relentless, and often lethal disease which kills usually by local occurrence and direct extension of the disease. The reported incidence of adenoidcystic carcinoma with reference to other parotid malignancies varies from 5% to 37%. The incidence in this series is 36%. The presence of facial nerve involvement adversely affects the long-term survival. Some authors regard facial nerve involvement as an indication of noncurability. The incidence of local pain is reported to be as high as 50% and is thought to be caused by perineural invasion by the tumor. This is well-documented histopathologically. There is no uniform or standard treatment for this disorder. Extensive resection of the parotid gland (including the facial nerve if there is any indication of involvement), followed by external irradiation to the parotid area and upper neck is the most rational approach to the problem. This is supported both in the review of the literature and from the present series. A radical neck dissection is not included as part of initial therapy unless there are clinically suspicious cervical nodes. Postoperative radiotherapy appears indicated in all cases of adenoidcystic carcinoma of the parotid gland. Four case histories are presented which demonstrate the hallmark characteristics of the disease, i.e. multiple cranial nerve deficits, facial pain and subsequent death by direct intracranial extension of disease. The protracted, relentless course of the disease is well-documented in one case in which 25 local recurrences developed over an 18-year period.
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PMID:Adenoidcystic carcinoma (cylindroma) of the parotid gland. 19 22

A thirty-four year old male presented with severe spot tenderness for eighteen months, situated in the right upper anterior thigh. The skin was normal. No tumor, swelling, or inflammation was found. On the basis of a clinical diagnosis of glomus tumor, the area was biopsied and a microscopic synovioma was documented in the fascia just deep to the subcutis. From the literature, it is apparent that approximately 20 percent of the patients with this cancer go through a pretumor phase characterized by only sustained pain or tenderness. By detecting the lesion in this phase, the dermatologist can contribute substantially to an increased cure rate, which has lingered at about 50 percent for at least ten years.
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PMID:Cutaneous pain without tumor: a manifestation of occult synovioma. 20 32

In eleven patients with atypical trigeminal neuralgia, following herpes infections or radiation therapy of cancer of the epipharynx, percutaneous electrical stimulation of the trigeminal tract or in the vicinity of the nucleus area was performed. Relief of pain lasting from fourteen days up to six weeks could be obtained.
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PMID:Percutaneous electro stimulation of the trigeminal nerve in patients with atypical trigeminal neuralgia. 20 12

Thirty-one cases of undifferentiated (embryonal) sarcoma of the liver are presented. The tumor is found predominantly in the pediatric age group, the majority of patients (51.6%) being between 6 and 10 years of age. An abdominal mass and pain are the usual presenting symptoms. Radiographic examination is nonspecific except to demonstrate a space-occupying lesion of the liver. The tumors are large, single, usually globular and well demarcated, and have multiple cystic areas of hemorrhage, necrosis, and gelatinous degeneration. Histologic examination shows a pseudocapsule partially separating the normal liver from undifferentiated sarcomatous cells that, near the periphery of the tumor, surround entrapped hyperplastic or degenerating bile duct-like structures. Eosinophilic globules that are PAS positive are usually found within and adjacent to tumor cells. Areas of necrosis and hemorrhage are prominent. The prognosis is poor, with a median survival of less than 1 year following diagnosis.
Cancer 1978 Jul
PMID:Undifferentiated (embryonal) sarcoma of the liver: report of 31 cases. 20 54

The experience of coping with lung cancer--from diagnosis to treatment to inevitable death--is indescribably difficult for the cancer patient. The nurse, with her basic knowledge of the disease process, diagnosis, prognosis, and treatment, and by employing her sensitivity to the patient's emotional needs, can ease the pain of this experience. The nurse must use her technical knowledge and understanding to provide the patient with the knowledge he needs to participate in his own care as well as the emotional strength to deal with the physiologic strains of the disease.
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PMID:The nursing care of lung cancer patients: emphasizing chemotherapy. 20 14

Data on 148 cases of liver tumor in women have been registered. Analysis of these data shows that 1) the average age is 30.3 years; 2) 85% of the patients had a history of oral contraceptive use; 3) pain was the most usual symptom followed by incidental discovery during an operation; 4) 19 were hepatomas, 56 were adenomas, 67 were focal nodular hyperplasia, and 6 were unclassified; and 5) 67% of the benign tumors were in the right lobe, there were 15 cases of multiple focal nodulat hyperplasia and 11 cases of multiple adenomas, and several of the adenomas were only partially encapsulated. The histopathologic differentiation of focal nodular hyperplasia from adenomas can be obtained by detection of the presence of bile duct epithelium in focal nodular hyperplasia; this is always absent in adenoma. Of the 19 patients with hepatomas, 12 have died (7 had metastasis, 3 deaths were related to the operative status), 2 are near death, and 5 are alive following resection. Treatment in most cases was resection or lobectomy, but biopsy only was performed in 22 cases of benign tumor. Follow-up of these cases should add to the knowledge about the necessity extent of surgery. The possible relationship of oral contraceptive use to liver oncogenesis is as yet undefined, but the incidence of tumors is very low considering the numbers of women who are current users of steroid contraceptives. Benign tumors have been reported to involute after discontinuation of steroidal medication. This therapeutic dilemma may be resolved when the patients in this series who underwent biopsy only have been followed for a longer interval.
Prog Clin Cancer 1978
PMID:Liver oncogenesis and steroids. 21 80

The American College of Surgeons conducted a survey of primary liver tumors in cancer-approved hospitals throughout the U.S. in the 6-year period, 1970-75. Of the 165 male cases identified, 91.5% were malignant, indicating the rarity of benign liver tumors in males. Of the 378 female cases located, 43.9% were malignant and 56.1% were benign. Nearly 50% of all primary liver tumors were found in women with a positive history of OC (oral contraceptive) usage, with OC history unknown in 29% of the study population. OC users accounted for 65% of all benign tumors reported, 74% of all hepatic cell adenomas, 74% of all focal nodular hyperplasias, 80% of benign tumors in the 20-30 year age group, and almost 90% of hepatic cell adenomas in the age group 26-30. This incidence survey confirms the reported association between OC usage and some types of benign liver tumors, especially hepatic cell adenomas and focal nodular hyperplasias. It is pointed out, and illustrated with graphs, that the age pattern for benign tumores corresponds to the age pattern for OC use. More of the OC users who developed benign tumors had used mestranol, results confirming earlier reported associations. However, this may simply be due to the fact of mestranol's earlier availability. Symptomatology, particularly with regard to pain and mass, was more pronounced in OC users. Results on duration of OC use and any association with tumor development were inconclusive. The incidence of benign liver tumors has increased from 1970 to 1975.
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PMID:Survey of primary liver tumors and oral contraceptive use. 22 98

The belief that synoviomas differentiate from the synovial membrane has been widely accepted. Absolute proof is lacking, mainly because precancerous synovial atypia has not been documented in human tissue. During the last 50 years, pain has emerged as one of the significant features of synovioma, occurring very early in the course of the disease in some patients. Gross relationship to nerve, cumulative histological data, and theoretical relationships with three other cancers of neural origin suggest the nerve sheath as an alternate parent tissue for synovioma. Three cases illustrating nerve involvement are included.
Cancer Res 1979 Oct
PMID:The potential histogenic relationship of the peripheral nerve to synovioma. 22 19


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