Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors report one case of giant varicose ulcer in a woman aged 85 years, who suffered from diffuse subcutaneous calcinosis, in which, after a period of shooting pain, spontaneous rupture of the anterior tibial artery occurred. Suture of this artery at the base of the ulcer did not hinder healing.
 ...
PMID:[Giant ulcers with rupture of the anterior tibial artery in a patient with calcinosis and hypercalcemia]. 100 97

The authors report seven cases of calcinosis, two of which were intravenous (phlebolithiasis) and five subcutaneous. Radiography of the soft tissues revealed in some cases a truly calcareous shealth, the size of which would not have been suspected from a clinical examination. Extensive calcification may be surprisingly well tolerated and results only in torpid ulceration that heals with simple conservative methods. On the other hand, pain and secondary infections may necessitate surgical resection of the calcareous plaques after arteriography.
 ...
PMID:[Various cases of calcinosis]. 124 Nov 37

Extraskeletal soft tissue calcifications occur commonly in patients with uremia receiving dialysis. Rarely, a large tumoral calcinosis-like mass may develop. A patient receiving chronic ambulatory peritoneal dialysis for only 7 months developed a tumoral calcinosis-like mass that encased the extensor tendons of his wrist with loss of extensor tendon function, initially suggesting extensor tendon rupture. Surgical debridement restored tendon function. Tumoral calcinosis-like lesions are uncommon, but may cause limitation of joint movement, pain or ulceration through the skin. Measures aimed at controlling factors contributing to soft tissue calcification should be undertaken in any event whether surgery is required or not.
 ...
PMID:Massive soft tissue calcification causing complete loss of extensor tendon function in renal failure. 146 82

Although soft-tissue calcification is common in collagen vascular disease, paraspinal calcification in the cervical spine has not been described before. We studied five women with large, lobulated, predominantly homogeneous calcific masses centered on synovial articulations in the neck. Changes consisting of either osteolysis or erosions were evident. All patients had radiculopathy, focal pain, or stiffness. In two patients, the presence of hydroxyapatite crystals was confirmed on biopsy. Symptomatic cervical paraspinal calcifications in patients with collagen vascular disease cause large soft-tissue masses that mimic tumoral calcinosis.
 ...
PMID:Cervical paraspinal calcification in collagen vascular diseases. 187 39

A case of tumoral calcinosis of the hand is reported. The lesion was localized at the fifth digit of the right hand and caused pain and disability. The clinical, diagnostic and therapeutic problems of this rare soft tissue disease are discussed.
 ...
PMID:[Tumoral calcinosis. A case report]. 203 79

Tumoral calcinosis is presently a poorly defined disease. In its classic form, it consists of multiple large foci of benign mineralization in the soft tissue adjacent to bone near large joints. Patients are generally of African descent and are adolescents or young adults at presentation. Both metabolic and traumatic etiologies have been proposed. We report six adult Caucasian patients with lesions that pathologically resembled tumoral calcinosis. All lesions were small (less than 3 x 3 cm) and were located along the proximal linea aspera of the femur. All patients presented with pain. Because of the atypical patient population and the unusual size and location of the lesions, we refer to this process as a "tumoral calcinosis-like lesion." A typical radiographic appearance and location, together with appropriate clinical history, can strongly suggest this diagnosis.
 ...
PMID:Tumoral calcinosis-like lesion of the proximal linea aspera. 227 12

Calcinosis circumscripta was found in the metacarpal pad of an otherwise healthy young German Shepherd Dog. The lesion caused progressive lameness. Incomplete surgical excision alleviated pain, while preserving a functional metacarpal pad. There were no clinical or laboratory data to indicate impaired renal function in this dog. Five months after surgery, the lameness had not returned. Footpad calcinosis circumscripta has been previously described in older dogs with renal insufficiency.
 ...
PMID:Calcinosis circumscripta of the metacarpal pad in a dog. 229 43

Painful calcinosis appeared at the wrist of an eight-year-old girl with lead poisoning. Careful history revealed that calcification occurred at the site of previous extravasation of calcium disodium edetate (EDTA) used in chelation therapy. Light microscopic, ultrastructural, electron activation, and X-ray diffraction studies demonstrated apatites with some suggestion of an admixture of octacalcium phosphate.
 ...
PMID:Calcinosis at the site of leakage from extravasation of calcium disodium edetate intravenous chelator therapy in a child with lead poisoning. 310 62

Three children with hyperphosphatemic tumoral calcinosis, including 2 siblings, presented with recurrent pain and swelling of the legs. Laboratory tests, radiographs, and biopsy showed reactive new bone formation of unknown etiology in the diaphyses. The authors hypothesize a relationship between tumoral calcinosis, hyperostosis, and hyperphosphatemia and consider possible mechanisms.
 ...
PMID:Tumoral calcinosis, diaphysitis, and hyperphosphatemia. 671 23

Ninety-three percent of 59 patients with scleroderma reviewed in this study presented with Raynaud's phenomenon at a mean age of 43 years; 65% of these developed fingertip ulcers within 4 years. Other common findings were sclerodactyly, distal phalangeal resorption, calcinosis cutis, and digital contractures. Medical management of the digital ulcers with systemic and regional vasodilating drugs was unsatisfactory. Sympathectomy, when performed early, temporarily relieved vasospastic pain but did not affect the course of the ulcers. Severe digital pain was the most incapacitating symptom resulting from vasospasm early in the course of the disease and irreversible arterial luminal narrowing later in the course. Conservative fingertip amputations for nonhealing ulcers constituted the management of choice to eradicate the ulcer, to reduce or eliminate the pain, and to return the hand to early useful function. A decision tree for the management of these ulcers is proposed.
 ...
PMID:Management of sclerodermal finger ulcers. 672 88


1 2 3 4 5 6 7 8 Next >>