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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

One case of caecocaecal intussusception (case 1) and one case of caecocolic intussusception (case 2) in ponies are described. Case 1 showed mild abdominal discomfort for seven days followed by sudden death whereas case 2 showed continuous moderate pain for three weeks. At post mortem examination, case 1 showed intussusception of the base of the caecum into the body whereas in case 2, the entire caecum had invaginated into the right ventral colon. Histopathological examination showed that the lesions in both animals had been present for a long time.
Vet Rec 1989 Aug 12
PMID:Caecal intussusception in two ponies. 280 Feb 71

A telephone survey of 50 owners of blind dogs was made in order to assess how well visually deprived dogs can cope within their environment. Ten of the 50 dogs surveyed died or were euthanased as a direct result of their blindness or ocular disease. Three owners were unable to come to terms with their pet's visual loss. Two dogs died as a result of accidents directly associated with blindness and five dogs were euthanased due to pain caused by glaucoma. Twenty-seven owners reported permanent behaviour or temperament changes in their pets. Behavioural changes included a more cautious approach to the environment and closer contact with the owner. Owners were aware of an obvious compensatory reliance on the senses of hearing and smell. Permanent temperament changes were reported in only two dogs both of whom became more aggressive. Only six of the surveyed dogs were unable or unwilling to find their way around in familiar surroundings. The most consistent measures undertaken by owners to ensure the dogs' safety was to prevent access to roads and to ensure that there was minimal movement of furniture within the home. Six dogs lost interest in exercise after the onset of blindness but a further six were still allowed to roam at large. Of the 32 owners who accompanied their dogs eight reported that restraint on a lead was unnecessary. Twenty-eight owners had encountered people who had suggested it was unkind to keep a blind dog.
Vet Rec
PMID:Coping with blindness: a survey of 50 blind dogs. 322 13

Acupuncture analgesia works by stimulating large myelinated nerve fibres which conduct the stimulus to the spinal cord and higher centres. The ascending pain impulses are blocked by a complicated interaction in which serotonin, endorphins, encephalin, norepinephrine and substance P all play important roles. The practical applications of acupuncture in small animal practice are limited and require the cooperation of the owner and the animal. It is useful especially in caesarian sections, in patients with high risk conditions such as gastric torsion and as a post-surgical analgesic. It can also be used to advantage in combination with conventional anaesthetic agents.
Vet Rec 1988 Apr 09
PMID:Acupuncture analgesia: a review. 328 54

Radiography plays an essential part in the diagnosis of spinal disease in the dog. Careful positioning of the patient and attention to technique are important in obtaining diagnostic films and sedation or general anaesthesia is usually required, especially if the animal is in pain or muscle spasm. Additional information may be obtained by myelography, a technique in which a water-soluble iodine-containing contrast medium is injected into the subarachnoid space via the cisterna magna, under general anaesthesia. The advent of two new contrast media, iopamidol and iohexol, has rendered this a relatively safe procedure which may be carried out in practice. The radiological features of a variety of canine spinal conditions are discussed, including congenital and developmental abnormalities, infective, nutritional and degenerative conditions and trauma and neoplasia.
Vet Rec 1987 Jul 11
PMID:Radiographic examination of the canine spine. 330 14

This study was conducted to determine the source and number of primary sensory neurons (PSNs) innervating a mandibular molar tooth of a population of 15-18-week-old Sprague-Dawley rats. The pulpal tissue was exposed to horseradish peroxidase (HRP) pellets for 24 hours. Subsequently the animals were perfusion fixed and the following PSN structures were examined for the presence of HRP-labelled cells: trigeminal (TGs) and cervical dorsal root ganglia (DRGs) and mesencephalic nucleus (MN). Only the TGs contained labelled cells and they thus were the sole source of PSN pulpal innervation. The number of TG cells was highly variable, 49-407, but most of this variability was attributable to insufficient HRP filling of the pulp chamber or leakage of HRP into periapical tissue. Selection of TGs whose respective experimental teeth demonstrated that HRP filled and was restricted to the pulp chamber revealed a narrower range of TG cells providing pulpal innervation to the first molars, 142-288, with an average of 213. A detailed mapping of these cells indicated a somatotopic distribution within the mandibular territory of the TGs. It was concluded that these findings represent TG's contribution to the pulpal innervation of this specific population of rat first molar teeth. This suggests that from animal to animal the density of innervation may be quite variable and it is hypothesized that the sensitivity of the pulp would likewise vary. In addition, these findings may contribute to the explanation of why there is variability in the stimulus strength needed to elicit a pain response in the human dentition.
Anat Rec 1987 Oct
PMID:Innervation of rat molar teeth: II. A quantitative analysis of primary sensory neurons innervating a mandibular molar tooth. 368 72

Despite some views to the contrary the working party of the Association of Veterinary Teachers and Research Workers considers that it has been demonstrated that it is possible to prepare guidelines for the recognition and assessment of pain in experimental animals. The detailed information readily available on species specific signs is limited and it has been particularly difficult to obtain such signs for the smaller mammals and for the non-mammalian species.
Vet Rec 1986 Mar 22
PMID:Guidelines for the recognition and assessment of pain in animals. Prepared by a working party of the Association of Veterinary Teachers and Research Workers. 370 73

After injection of true blue (TB) into the pericardial sac and nuclear yellow (NY) into the left ulnar nerve of rats, most perikarya in the left eighth cervical and first thoracic dorsal root ganglia are single-labeled with either TB or NY. However, 7.1-14.7% of the sensory perikarya from the cardiac area labeled with TB are simultaneously labeled with NY. This finding indicates that some primary sensory perikarya receive processes from both the left arm and the heart. In addition to other mechanisms that may be operative in the referral of pain of cardiac origin to the medial left arm, these results suggest that sensory neurons with dichotomizing somatic and visceral peripheral processes may also contribute to this phenomenon.
Anat Rec 1986 Apr
PMID:Convergence of sensory processes from the heart and left ulnar nerve onto a single afferent perikaryon: a neuroanatomical study in the rat employing fluorescent tracers. 370 87

Under the 1876 Cruelty to Animals Act it is necessary to recognise pain so that an assessment may be made to determine if it is 'an experiment calculated to give pain' and 'to prevent the animal feeling pain'. Under the conditions of the licence it is also necessary to recognise 'severe pain which is likely to endure' and 'suffering considerable pain'. In the White Paper May 1983 (Command 8883) it is stated that: 'in the application of controls the concept of pain should be applied in a wide sense' and 'the Home Secretary's practice has been to interpret the concept of pain to include disease, other disturbances of normal health, adverse change in physiology, discomfort and distress'. The draft European Convention for the Protection of Vertebrate Animals used for Experimental and other Purposes, aims to control, subject to specific exceptions, any experimental or other scientific procedure which 'may cause pain, suffering, distress or lasting harm'. (The White Paper states that UK control will be stricter than the Council of Europe proposals.) Thus, there is a considerable onus on the experimenter to recognise pain (not to define it) and to alleviate it. It is intended that this article should be of help, not only to newcomers inexperienced in the recognition of pain, but also possibly to those relatively experienced workers who may be called upon to evaluate the pain involved in a new model or an individual animal.(ABSTRACT TRUNCATED AT 250 WORDS)
Vet Rec 1985 Apr 20
PMID:Guidelines on the recognition of pain, distress and discomfort in experimental animals and an hypothesis for assessment. 392 90

Nerves exhibiting substance P-like immunoreactivity were demonstrated in the human periosteum. A network of nerves showing substance P-like immunoreactivity was seen in the periosteum, while finer strands of immunoreactive nerve fibers were present immediately beneath the surface of the periosteum. Enkephalin-like immunoreactivity was also studied but could not be demonstrated. Substance P has previously been suggested to be involved in the mediation of the sensation of pain. The clinically observable marked pain sensitivity of periosteal tissue might be explained by the peptidergic nerves described in this paper.
Anat Rec 1984 Jul
PMID:Innervation of human bone periosteum by peptidergic nerves. 620 9

Using electron microscopy and morphometric analysis the number and size of axons entering the apex of the cat's mandibular canine tooth have been measured. The total number of axons varied from 761 to 1,903 between different animals but the maximum difference between right and left sides of the same animal was 353. From 56 to 79.6% of the axons were nonmyelinated; the difference in proportion between right and left sides never exceeded 6.4%. The mean circumference of myelinated axons ranged from 10.2 to 18.3 micrometers but again the right and left variation was much less and never exceeded 2 micrometers. In one tooth 38.8% of the myelinated axons were larger than 19 micrometers in circumference and thus outside the A delta range. The proportion was much smaller in other teeth but some "large" fibers were always present. Of all the nonmyelinated axons 19.7% showed some degree of axonal exposure to the extracellular space and 1.7% showed ax-oaxonal apposition. A small proportion of nonmyelinated axons showed evidence of apparent degeneration. Comparison of these data with those from studies at more coronal levels suggests that there is considerable branching and narrowing of fibers during their course through the dental pulp and that the degree of axonal exposure and apposition increases considerably. Some of the pulpal fibers are derived from larger axons than are normally associated with pain. The animal to animal variation in the parameters measured is considerable but right and left sides are similar.
Anat Rec 1983 Feb
PMID:The number and size of axons at the apex of the cat's canine tooth. 684 72


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