Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0029713 (immaturity)
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Human Gene/Protein
SERPINE2 protein 11.8
TSEN34 10.8
HCDI 10.8
KLEIP 10.8
Hermansky-Pudlak syndrome type 1 10.5
KPTN 10.3
SEN34 10.3
pregnancy specific beta-1-glycoprotein 10.0
Dihydropyridine receptor 9.8
SLC38A5 9.4
TSEN2 9.4
GPR146 9.4
edg-2 9.4
Monad 9.4
collagenous Alzheimer amyloid plaque component 9.3
Neurogenin 1 9.1
Maltase-glucoamylase 9.0
SCTR 9.0
pregnancy-specific beta-1 glycoprotein 9.0
FATZ 9.0
concentrative nucleoside transporter 1 8.9
Acyloxyacyl hydrolase 8.8
PARP-14 8.8
Junctin 8.8
NKG2B 8.6
neuropeptide S receptor 1 8.6
PIN1 protein 8.5
RARS2 8.5
BAVM 8.3
pp52 8.3
peptide transporter 2 8.3
SREB2 8.2
TSEN54 8.1
ALTE 8.1
2E4 8.0
HLA-2 8.0
Cysteine-rich protein 8.0
paired box transcription factor 7.9
ARHGDIB 7.8
PRKCZ 7.7
ANG2 7.7
RLF 7.7
Triadin 7.7
CD1B 7.7
PARP9 7.6
HIVEP2 7.6
sodium-dependent neutral amino acid transporter 7.6
ANG1 7.6
nebulette 7.5
C/EBP epsilon 7.5
HD-6 7.5
desmosomal glycoprotein 1 7.5
RDS 7.5
JMJD2B 7.5
TOLLIP 7.5
JMJD2C 7.4
SFTPA1 7.4
SP-A1 7.4
RBM20 7.3
Na+ channel protein 7.3
OX-2 7.3
SP-A2 7.2
CD 16 7.2
PKR1 7.2
DAPK2 7.2
ABCA3 7.2
PKD2L1 7.1
LAMP3 7.0
GPR84 7.0
MYBL1 7.0
thymocyte antigen 7.0
HSD17B2 7.0
forkhead box A2 6.9
NPSR 6.9
GDF3 6.9
ARPKD 6.9
CD7 antigen 6.8
ACVR2A 6.8
pyrroline-5-carboxylate reductase 6.8
NUDT15 6.8
more...
Disease
Central nervous system vascular disorders 12.8
immaturity 12.8
Anoxic-ischemic encephalopathy 11.8
Sexual immaturity 11.8
personality problem 11.5
Pulmonary immaturity 11.3
Recurrent bronchitis 10.8
Ohdo blepharophimosis syndrome 10.5
Neonatal hyperglycaemia 10.3
Transient hypothyroxinemia 10.3
Axenfeld's syndrome 10.3
Generalized osteopenia 10.3
PCH5 10.0
Genitourinary infection 10.0
Benign Familial Neonatal Convulsions 9.8
Gallbladder sludge 9.7
PCH4 9.7
Penile Cancer 9.7
Neonatal respiratory distress syndrome 9.4
Transient tachypnea of newborn 9.3
Wilson-Mikity syndrome 9.2
Erythema toxicum neonatorum 9.1
Funisitis 9.0
Neonatal hypocalcemia 9.0
Kohler's disease 9.0
Acute basophilic leukemia 9.0
sideroblastosis 8.9
Sinding-Larsen-Johansson disease 8.8
Thyroid hyperplasia 8.8
PCH1 8.7
panmyelosis 8.6
Recurrent respiratory tract infections 8.5
infectious encephalomyelitis 8.5
hyaline membrane disease 8.5
Neonatal hyperbilirubinemia 8.5
Toriello-Carey syndrome 8.5
IgG1 deficiency 8.5
Clonic seizures 8.3
Solitary plasmacytoma of bone 8.3
Congenital myotonic dystrophy 8.3
Pediatric Tumor 8.1
osteochondropathy 8.1
Neonatal necrotizing enterocolitis 8.1
Sensenbrenner syndrome 8.1
Miliaria crystallina 8.0
Neonatal cholestasis 8.0
Immature teratoma 7.9
Respiratory morbidity 7.9
RDS 7.9
MODY4 7.8
Combined immunodeficiency 7.8
PCH2 7.8
Neonatal meningitis 7.8
tetrasomy 9p 7.7
Hypoglycemic episodes 7.6
Mirror movements 7.6
brief reactive psychosis 7.6
emotional maladjustment 7.6
Ventilator associated pneumonia 7.5
myometritis 7.5
X-linked hypogammaglobulinemia 7.5
Congenital infections 7.5
Neonatal encephalopathy 7.3
adjustment reaction 7.3
Severe pre-eclampsia 7.3
Grisel's syndrome 7.3
bestiality 7.2
infantile eczema 7.2
necrotizing enterocolitis 7.2
infantilism 7.2
Neonatal sepsis 7.1
Dermatitis artefacta 7.1
prematurity 7.1
disaccharidase deficiency 7.0
Renal scarring 6.9
Amniotic band syndrome 6.9
osteomyelosclerosis 6.8
IgG subclass deficiency 6.8
leukemoid reaction 6.8
bronchopulmonary dysplasia 6.8
more...
Symptom
Nasal regurgitation 10.5
Dysdiadochokinesis 10.5
Procedural pain 9.8
change in skin color 9.1
Intermenstrual bleeding 7.8
Infantile colic 7.0
Q angle 6.8
Motor dysfunction 6.5
Periodic breathing 6.4
gumma 6.3
bedwetting 6.2
enuresis 6.0
Macula 6.0
Crushing 5.9
respiratory distress 5.8
Severe pain 5.5
breath holding 5.3
impaired motor coordination 5.3
irregular bleeding 5.3
tonic seizure 5.1
inanition 5.0
tachypnea 5.0
clumsiness 4.7
hyperoxia 4.6
thirsty 4.5
hypercapnia 4.3
Involuntary Movement 4.2
tonic-clonic seizure 4.1
Halo 4.0
sneezing 3.9
hypotonia 3.9
abdominal cramps 3.8
urinary frequency 3.7
night sweats 3.6
chronic constipation 3.5
Sedation 3.5
partial seizure 3.4
CSR 3.4
Neuropathic pain 3.4
hypothermia 3.3
clonus 3.3
anosmia 3.3
physical appearance 3.3
stridor 3.2
colic 3.2
consciousness disturbance 3.2
hypocapnia 3.1
alexithymia 3.1
incoordination 3.1
oliguria 3.0
neurological disability 3.0
cyanosis 3.0
acute pain 2.9
dry skin 2.9
regurgitation 2.8
hypersomnia 2.8
emaciation 2.8
microbial colonization 2.8
Postoperative pain 2.8
hepatosplenomegaly 2.7
productive cough 2.7
hypoproteinemia 2.7
hopelessness 2.7
decreased appetite 2.7
pallor 2.5
Mills 2.5
exhaustion 2.4
hepatomegaly 2.3
constipation 2.3
skin damage 2.3
seizures 2.2
wheezing 2.2
torticollis 2.2
weakness 2.2
paresthesia 2.2
abdominal discomfort 2.1
hip pain 2.0
memory loss 2.0
thinning 2.0
splenomegaly 1.9
more...
Drug
Lucinactant 9.8
Loxoribine 9.3
Simethicone 9.0
1,4-Butanediol 8.0
Ditropan 7.7
Ditropan 7.4
Calcium gluconate 7.3
FLM 7.2
Lenograstim 7.1
Dopexamine 6.9
Omniscan 6.5
Coconut oil 6.2
Ethane 6.1
Omniscan 5.7
Meconium 5.5
Iodixanol 5.5
BLyS 5.2
Survanta 5.1
Giardiasis 5.0
Sumatran 4.6
Depo-Provera 4.5
Codeine 4.4
RSM 4.4
Filgrastim 4.4
HPMPC 4.4
Codeine 4.3
DMSA 4.3
Dextrose 4.2
Filgrastim 4.2
Liraglutide 4.1
LCM 4.1
LCM 4.1
MEA 4.0
APD 4.0
anti-RSV 4.0
Luteinizing 3.8
Sinemet 3.8
Levonorgestrel 3.7
Salicylate 3.7
Clofibrate 3.7
PPA 3.6
PDL 3.5
HCG 3.5
Isotretinoin 3.5
CIA 3.2
Rosiglitazone 3.2
Norplant 3.2
Lipiodol 3.2
IL-2 3.1
Diurnal 3.1
Norplant 3.1
Adenosine triphosphate 3.0
Amoxicillin 3.0
IFN-gamma 3.0
DDAVP 2.9
DDAVP 2.9
Sodium nitroprusside 2.9
Growth hormone 2.9
Theophylline 2.9
Growth hormone 2.9
Frontal 2.8
Galactose 2.8
uPA 2.8
BCG vaccine 2.7
DPA 2.5
caffeine 2.5
Fentanyl 2.5
CCL 2.5
G-CSF 2.5
AZT 2.5
Spectrum 2.4
ALA 2.4
Amiloride 2.3
Sorafenib 2.3
AZT 2.3
Bayer 2.2
VCR 2.2
DM1 2.2
Ranitidine 2.2
TAC 2.2
more...
Enzyme
splicing endonuclease 6.5
phosphoserine phosphatase 5.8
proline oxidase 5.8
arginyl-tRNA synthetase 5.7
lactase-phlorizin hydrolase 5.5
lactase-phlorizin hydrolase 5.1
TdT 5.1
PRT 5.0
lactase 4.8
CD13 4.7
CDH 4.7
PNL 4.4
chymase 4.0
sucrase 3.9
nucleotidase 3.8
cystathionine gamma-lyase 3.8
arginase 3.8
CNPase 3.8
ADPase 3.7
cytochrome P-450scc 3.7
1-hydroxylase 3.7
CD10 3.7
alpha-glucosidase 3.6
p-nitrophenylphosphatase 3.6
factor C 3.5
BMT 3.5
adenine phosphoribosyltransferase 3.4
GCA 3.4
fatty acid desaturase 3.4
phenylalanine hydroxylase 3.4
6-phosphogluconate dehydrogenase 3.3
ornithine aminotransferase 3.3
6-phosphogluconate dehydrogenase 3.3
insulin-degrading enzyme 3.3
caspase-2 3.3
caspase-2 3.2
dipeptidyl peptidase IV 3.1
succinic dehydrogenase 3.1
sucrase-isomaltase 3.1
prolyl hydroxylase 3.0
diaphorase 3.0
delta-aminolevulinic acid dehydratase 3.0
3beta-hydroxysteroid dehydrogenase 3.0
adenosine kinase 3.0
BIS 2.9
cytidine deaminase 2.9
adenosine deaminase 2.8
adenosine deaminase 2.8
5'-nucleotidase 2.8
glutamate decarboxylase 2.8
ADH 2.7
myosin ATPase 2.7
acid phosphatase 2.7
Thy1 2.6
invertase 2.6
lysyl oxidase 2.6
tissue kallikrein 2.5
ceruloplasmin 2.5
NADPH-diaphorase 2.5
neutrophil elastase 2.4
tryptase 2.4
dopamine beta-hydroxylase 2.4
PGM 2.4
purine nucleoside phosphorylase 2.4
glucokinase 2.4
diaphorase 2.3
MAT 2.3
apyrase 2.3
glucose-6-phosphatase 2.3
MAT 2.1
pyruvate kinase 2.1
alpha-amylase 2.1
hexokinase 2.1
glycerol-3-phosphate dehydrogenase 2.1
AOR 2.1
tryptophan hydroxylase 2.1
peroxidase 2.1
glycerol-3-phosphate dehydrogenase 2.0
prostaglandin synthetase 2.0
tyrosine hydroxylase 2.0
more...
Compound
F-26 11.3
Diphemanil 9.5
5C-aglycone 9.5
C18H18O4 9.3
HPLA 8.8
Tranzer 8.5
Ribose, 7.7
Methylazoxymethanol 7.4
cholest-5-en-3-one 7.4
1-naphthyl acetate 6.8
ED 20 6.3
Semicarbazide 6.2
Chlorpropamide 6.2
hydroxytyramine 6.2
DHM 6.0
Betamethasone 6.0
cholan-24-oic acid 6.0
Oxybutynin 6.0
2-phenoxyethanol 6.0
Retinyl palmitate 5.9
cholan-24-oic acid 5.9
Tolazoline 5.9
Ritodrine 5.8
DAU 5.8
DAU 5.6
Methoxychlor 5.6
Nalbuphine 5.5
COA 5.5
Cholic acid 5.5
Atracurium 5.3
Pancuronium 5.1
Chenodeoxycholic acid 5.1
Levonorgestrel 5.0
Cortisone 5.0
Terfenadine 4.9
4-hydroxyphenylpyruvate 4.9
VMA 4.8
17-OHP 4.8
Diol 4.7
HMS 4.7
NMN 4.7
Chlorambucil 4.7
Bilirubin 4.6
Parenteral 4.6
FMNH 4.5
MNU 4.5
CDH 4.5
Meperidine 4.4
Codeine 4.4
Fenfluramine 4.4
Clotrimazole 4.4
Phenylalanine 4.4
Metoclopramide 4.4
Xanthine 4.4
Efavirenz 4.4
Permethrin 4.3
Emery 4.3
Pindolol 4.2
Prone 4.2
6-Mercaptopurine 4.2
Phosphatidylcholine 4.2
Cystine 4.1
VM-26 4.1
DDC 4.1
5-Azacytidine 4.1
DDC 4.1
fructose-6-P 4.0
DTP 4.0
MEA 4.0
EOS 4.0
TBS 3.9
TCDD 3.9
Sphingomyelin 3.9
H-3 3.8
Alum 3.8
Dynorphin 3.8
DNFB 3.8
Sudan I 3.8
Danazol 3.7
Clofibrate 3.6
more...