Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0029713 (immaturity)
 4,335 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Concerning the well known stimulative effect of ethanol on the secretory activity of the intermediary lobe of the hypophysis in mature animals, the effect of the same agent was analyzed in the young of the alcoholized parents. Immediately after animals were parted from their alcoholized breast feeding mothers the hypophyses of the young old 1, 10, 20 and 30 days were taken for hystological analysis. In the first day of postnatal life the intermediary lobe is completely developed so that it has a glandular tissue covered by marginal epithelium; but structural changes connected with the influence of alcohol were not noticed. In the young old 10 days, the initial hyperplasia of the gland cells in the intermediary lobe was noticed and intermediocytes penetrated deep into the posterior lobe area. Histological findings at the 20th and 30th day of life are similar and manifested through the prominent hyperplasia of the glandular cells and through the hyperfunction certified by a rich content of intermediocytes in the RNA and the intensified activity of succinate-dehydrogenase and NADH diaphorase at the level of the marginal epithelium. The fact that the intermediary lobe cells are not able to react on the alcohol stimulation before the 10th day of life could be explained by the immaturity of the neurotransmitter system.
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PMID:[The effect of alcohol on the intermediate hypophyseal lobe in the early postnatal period]. 263 84