Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029713 (immaturity)
 4,335 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sixty two samples of amniotic fluid were submitted to biochemical investigation including 31 samples from women with pregnancy complicated by hypertension (studied group with blood pressure -65 +/- 15/95 +/- 5 mm Hg) and 31 samples deriving from healthy pregnant women (control group with mean blood pressure 118 +/- 10/74 +/- +/- 9 mm Hg). The following parameters of amniotic fluid were measured: 1) aminotransferases: alanine AlAT and aspartate AspAT, 2) alkaline phosphatase (APt) and its thermostable isoenzyme (APh), 3) ceruloplasmin (Crlp), 4) alpha-amylase (alpha-Amy). The study showed pregnancy complicated by hypertension is related to fetal salivary gland's immaturity presenting decreased activity of alpha amylase in amniotic fluid. Amniotic fluids deriving from women with pregnancy complicated by hypertension showed normal activities of AlAT, AspAT, APt, APh and Crlp.
Ginekol Pol 1996 Dec
PMID:[Evaluation of fetal condition in pregnancy complicated by hypertension--biochemical assessment of amniotic fluid. II. Enzymes]. 928 52

It has been observed that immunological reactivity of neonatal leukocytes is diminished. It seems to result from lymphocytes immaturity. In the present study we have evaluated the phenotype of cord blood lymphocytes with the use of flow cytometry. In neonates we have observed the increase in the absolute number of CD1a and CD7 positive lymphocytes as well as CD2, CD3, CD4, CD8, CD16, CD19 and CD20 positive, while number of CD57 positive cells was significantly decreased. The ratios of CD4/CD8 and T/B lymphocytes were similar to the corresponding ratios observed in adults. Our results have shown the presence of immature lymphocyte population as well quantitative depletion of subpopulation of CD57 cells, what may pose an increased risk of infection in neonates. Nevertheless, increased number of T and B lymphocytes with mature phenotype along with normal ratio of lymphocyte subpopulations and increased number of CD16 positive cells (NK cells), may explain phenomenon of good health among majority of newborns.
Ginekol Pol 1998 Apr
PMID:[Flow cytometric analysis of cord blood lymphocytes]. 964 Aug 62

The aim of this study is a clinical and electroencelographic analysis of those SSPE patients who suffered epileptic seizures in course of the disease. The material is based on an analysis of a computed database including 1180 case histories from multiple hospitalizations of 248 SSPE patients (141 males, 107 females) in years 1978-1995. The analysis was made using computer system EPI-INFO 6. The average age of SSPE onset was 12.3 +/- 4.5 (range 4-27.5). 74.2% of patients developed the disease before the age of 15. Epileptic seizures occurred in 43.5% (N = 108) of all SSPE patients in different stages of the disease. In 47 patients (M-21; F-26) they were observed among first SSPE symptoms, in 41 of those the seizures had the form of GTCS. Epileptic seizures were more frequent in patients with SSPE onset before the age of 15 (50.5%) than in patients with later onset (23.4%). More frequent occurrence of epileptic seizures and epileptiform changes in EEG in children under 15 can be associated with specificity of developmental age: immaturity of nervous and endocrine system and decreased convulsant threshold.
Neurol Neurochir Pol
PMID:[Epileptic seizures in relation to the age of SSPE onset]. 1046 23

Clinical and morphological analysis was made to assess 9 cases of minimal change disease (MCD) and 30 cases of mesangial glomerulonephritis (GNMES) recognized by light microscopy with unfavourable course. Case selection was based exclusively on the clinical course suggesting a possibility of early sclerosis (long-term steroid resistance, frequent recurrences, rare short-lasting remissions, hypertension, renal failure). It was found that the unfavourable clinical course was clearly more frequently associated with electron microscopic than light microscopic changes. Marked increase of the matrix was observed also in those glomeruli in which light microscopy did not reveal any changes or only the signs of immaturity. It was also noticed that in those cases in which the assessment of mesangial matrix increase (which means the onset of sclerosis) is not certain, it is useful to make a morphometric analysis of electron microscopic material.
Pol J Pathol 1999
PMID:Clinical and morphological (including morphometric) aspects of minimal change disease and mesangial glomerulonephritis with unfavourable course in children. 1062 18

It has been observed high risk of infections in neonates as a result from lymphocytes immaturity. It is connected to phenotype differences of lymphocytes between neonates and adults. This high susceptibility to infections is especially high in premature neonates. With the use of flow cytometry we have evaluated the phenotype of cord blood lymphocytes in premature neonates. In comparison to results of healthy newborns we have observed significant decrease in CD7+, CD3+, CD4+, CD25+, CD57+ lymphocytes an increase in total number of CD8+ cells as well as alteration in CD4/CD8 ratio. Our results suggest deeply damage of cellular immunity in preterm infants.
Ginekol Pol 2000 Feb
PMID:[The phenotype characteristics of cord blood lymphocytes in premature neonates]. 1076 3

Respiratory distress syndrome (RDS) as a consequence of lung immaturity remains a major cause of perinatal morbidity and mortality. TRH used with glucocorticoids shows synergistic influence on surfactant synthesis and morphological lung maturation in preterm born infants. The purpose of this study was to examine the influence of antenatal TRH + glucocorticoids treatment on survival rate of extremely low birth infants (less than 1000 g). We evaluated 94 premature neonates born between 1993 and 1997 at the Department of Obstetrics and Perinatology of University School of Medicine in Lublin. Better survival rate of extremely low birth infants was observed in the TRH + steroids group then in only steroids one. The ratio of RDS was similar in both groups. Further investigations to determine the safety and efficacy of antenatal TRH therapy are needed.
Ginekol Pol 2000 Feb
PMID:[The influence of antenatal TRH and glucocorticoids therapy for survival rate of extremely low birth infant]. 1076 4

The development of ultrasound examination lets us perform the biophysical assessment of fetus lungs. From 1986, at the Ivth Clinic of Obstetrics and Gynecology in Tychy, examinations of fetus lung were performed with Siemens and Bruel & Kjaer real-time ultrasonographic equipped. The elasticity of fetal lung (DLS--dynamic lung score) was estimated by taking a transversal section through the fetal chest in a plane at fetal in a plane at fetal heart and presented in 3-grade scale: I-grade--lack of elasticity (immaturity of lungs), II-grade--non complete elasticity, III-grade--normal elasticity (maturity of lungs).
Ginekol Pol 2000 Apr
PMID:[Ultrasound evaluation of fetal lung maturity in imminent preterm labor cases]. 1086 Feb 73

Prenatal diagnosis of amniotic fluid enables fetal maturity evaluation, particularly that of fetal lungs. The aim of the study is to evaluate the diagnostic value of on alpha-amylase/glucose index in amniotic fluid in comparison to routinely performed tests, used for prenatal fetal lung maturity evaluation, particularly in respect of PG concentration, whose predictive value is almost 100%. The study was carried out on 180 pregnant women, chosen by random selection, hospitalized in Polish Mother's Health Centre Hospital in the period from 15.06.1994 to 31.12.1995. 223 samples of amniotic fluid were tested- in all samples following assays and tests were performed: bubble stability test (BST), optical density, orange cells test, phosphatidylglycerol concentration (PG), glucose concentration, alpha-amylase activity urea and creatinine concentration. The alpha-amylase/glucose index in amniotic fluid is statistically significant with PG concentration. The value of the alpha-amylase/glucose index is < 6.0 when amniotic fluid assay indicates fetal immaturity, but when amniotic fluid assay indicates fetal maturity, its value is 36.0. The evaluation of fetal lung maturity on the basis of the alpha-amylase/glucose index multiply decreases the cost of examinations. Authors make a suggestion to implement this method in all hospital departments of the country.
Ginekol Pol 2001 Sep
PMID:[Alpha-amylase/glucose index in amniotic fluid as a new method in prenatal assessment of fetal maturity]. 1175 81

Human cytomegalovirus (HCMV) infects about 60% of adults in developed world and more than 90% of developing countries population. In the immunocompetent host, initial infection and reactivation of latent infection are usually asymptomatic. However, in hosts with impaired cellular immune functions, such as transplant recipients, patients infected with human immunodeficiency virus (HIV) or undergoing anticancer chemo- and/or radiotherapy, the full pathogenic potential of the virus may be realized. HCMV is also among the most common causes of viral intrauterine infection affecting from 0.4 to 2.3% of live-born infants. Though in pregnant, immunocompetent women infections with HCMV are usually asymptomatic, severe infections may occur among congenitally infected fetuses and infants due to immaturity of their immune system. Approximately 40% of mothers with primary HCMV infections during gestation transmit virus to their infants. Although only 10% of infected infants are symptomatic at birth, 20 to 30% of these die. In addition, 5 to 15% of asymptomatic neonates are at risk of developing congenital anomalies later. In this outline we present anti-CMV drugs currently in clinical use and give examples of new molecules under laboratory and clinical development.
Pol Merkur Lekarski 2002 Sep
PMID:[Drugs against human cytomegalovirus]. 1247 80

The easiness of pathological process spreading and difficulties with disease confinement are the most characteristic features of tuberculosis in childhood. These are mainly due to immaturity of both respiratory and immune systems. The infection with Mycobacterium tuberculosis gives rise to formation of granuloma, a product of macrophage accumulation, which develops due to proliferation of mycobacteria and remains a prominent pathogenic finding in Tbc. A functional equilibrium between the efficacy of cell-mediated immunity (necessary for eradication of the pathogens) and tissue-destructive delayed-type hypersensitivity reaction are observed in Tbc-infected individuals. IL-12 and IFN-gamma, as strong activators of the Th1-driven immune response, are considered as crucial for successful eradication of Mycobacteria. The functional predominance of humoral immune response is a distinctive mark of immune response in childhood and is regarded as the risk factor associated with poor clinical outcome. The determinants have been shown of immune response against Mycobacteria with a special consideration of childhood Tbc.
Pol Merkur Lekarski 2003 Aug
PMID:[Immune mechanisms in children with tuberculosis]. 1464 95


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