Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029713 (immaturity)
 4,335 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Surface phenotype of peripheral blood lymphocytes (PBL) from preterm infants was evaluated using monoclonal antibodies which define T cell membrane antigens associated with processes of maturation and activation of these cells. In the majority of preterm infants born during the 25th and 26th week of gestation, PBL included higher percentages of cells bearing an immature/activated surface phenotype characterized by the presence of CD1, CD38, and CD71 surface antigens than in term newborns. In these gestational age groups, PBL included, in particular, very high percentages of lymphocytes (range: 22-60) expressing the p55 chain of interleukin-2 receptor (IL-2R). After the 26th week of gestation, PBL of some preterm neonates included, as well, high percentages of lymphocytes bearing immature/activated phenotype; their median values, however, were not significantly different from those observed in term newborns. Our data suggest that the presence of the p55 chain of IL-2R on the surface of neonatal lymphocytes could be correlated with the immaturity of these cells.
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PMID:Lymphocyte subpopulations in preterm infants: high percentage of cells expressing P55 chain of interleukin-2 receptor. 207 24

The Fgr protein-tyrosine kinase, p55(c-fgr), is specifically expressed and functions in cells of myelomonocytic lineages. We examined levels of expression and enzymatic activity of p55(c-fgr) peripheral blood neutrophils of patients with myelodysplastic syndromes (MDS) and chronic myelogenous leukemia (CML) by comparison with those of normal individuals. While neutrophils of eight normal subjects gave uniform results, the specific enzymatic activity of p55(c-fgr), a ratio of the total kinase activity versus the protein level was reduced in seven out of eight patients with MDS and all of five patients with CML. The specific kinase activity of p55(c-fgr) correlated significantly with the activity of neutrophil alkaline phosphatase (NAP) which has been considered to be a marker of neutrophil maturity (r=0.568, P<0.01). The reduced activity of this tyrosine kinase was considered to be a biological parameter for immaturity and to reflect dysfunction of neutrophils of patients with MDS and with CML.
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PMID:Activity of Fgr protein-tyrosine kinase is reduced in neutrophils of patients with myelodysplastic syndromes and chronic myelogenous leukemia. 863 16