Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029713 (immaturity)
 4,335 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The immaturity of antioxidant capacity in the lung in preterm newborn infants is postulated to contribute to the development of hyperoxic lung injury. Antioxidant enzymes in fetal lung, comprised of copper-zinc (cytosolic) and manganese (mitochondrial) superoxide dismutases, glutathione peroxidase, and catalase, have been reported to increase during the late gestational period. To determine whether such maturation of antioxidant capacity occurs in other tissues, we have evaluated the development of these four enzymes from d 18 to 22 of gestation in rat lung, kidney, and heart. To resolve the confusion in the reported levels of lung superoxide dismutases, the two isoenzymes were assayed separately by specific RIA. The growth of the kidney exceeded that of the whole body during this period, while the growth of the lung and heart did not. The concentrations of the four antioxidant enzymes in lung and kidney increased in a stepwise manner during this period, and the magnitude of the change for each enzyme was greater in the kidney than in the lung. On the other hand, the only significant change in the concentrations of heart antioxidant enzymes observed was a mild increase in the glutathione peroxidase concentration from d 20 to 22. These results suggest that the prenatal maturation of antioxidant capacity occurs earlier in the heart and later in the kidney than in the lung, and that the immaturity of antioxidant capacity could make the fetal rat kidney vulnerable to free radical-mediated injury.
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PMID:Prenatal development of antioxidant enzymes in rat lung, kidney, and heart: marked increase in immunoreactive superoxide dismutases, glutathione peroxidase, and catalase in the kidney. 234 74

Optimalize the feeding of low birth weight infants is a very important problem in industrial as well as in developing countries where such infants are very numerous. Water need is very important but gastric and vascular capacity is limited in LBW infants. Energy has to be absorbed at a rate of 120 to 130 Kcal/kgBW/day without raising the osmolarity of the food. Protein intake has to be higher than in term babies but due to enzyme and kidney immaturity the amino acid pattern of the protein has to be carefully adapted to the pattern of the proteins to be synthesized. Calcium, phosphorus, iron, zinc and other trace minerals as well as vitamins have to be provided in relatively large quantities but their bioavailability has also to be checked. The utilisation of breast milk and particularly of own mothers milk having delivered prematurely is also discussed.
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PMID:[New aspects in the nutrition of newborn infants with low birth weight]. 377 17

We report a breast-fed preterm infant (31 weeks gestation) who developed nutritional zinc deficiency 13 weeks post delivery. Serial samples of his mothers breast milk from early lactation (2 weeks post delivery) contained very low zinc concentrations, although her serum zinc and sweat zinc concentrations were normal. Following the birth of her second baby at 38 weeks gestation, her breast milk contained normal amounts of zinc. We conclude that the low breast milk zinc values obtained following the first pregnancy may have been due to immaturity of the milk. Units that feed very low birth-weight babies preterm milk should check its zinc concentration or at least have a high index of suspicion for this nutritional deficiency.
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PMID:Zinc deficiency: a problem with preterm breast milk. 398 80

Ninety minutes after i.p. injection of 3 mumol of cadmium chloride/100 g body weight into immature, 15 day-old rats, the endothelial intercellular junctions of the caput epididymis capillaries showed none of the lesions such as loss of junctional associated ectoplasmic microfilaments, separation of interdigitated leaflets, disassembling of interendothelial tight junctions, passage of blood plasma and cells into the pericapillary space, platelet clumping and disintegration, and intracapillary clotting, which after the same dose are found in sexually mature rat epididymides. The resistance of the immature, physiologically intraabdominal epididymal capillary endothelium reminds one of the protection against cadmium that is brought about by surgical cryptorchidism in adult mature rats. We suggest that either local enzyme immaturity or the abdominal temperature (5 degrees C than scrotal temperature) may protect zinc enzymes against displacement by cadmium.
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PMID:Refractoriness of the immature rat epididymis to the early cadmium lesion. 763 33

The frequencies of 10 diseases in a cadmium (and zinc) contaminated region in The Netherlands were analysed by comparing hospital admissions with those of a non-contaminated region and with national values. No significant differences were found for diseases which are commonly associated with increased cadmium uptake such as renal insufficiency, nephrolithiasis, hypertension, cancer, immaturity of the new-born. For the contaminated region a significantly higher frequency was only found for atherosclerosis; this was relatively strong for men aged > 40 yrs. However, no higher death frequency for atherosclerosis was observed. The results are discussed in relation to limitations in the evaluation techniques used. The absence of major health risks in the contaminated area is obvious, but the possible influence of long term-low level cadmium uptake on atherosclerosis requires more attention.
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PMID:Prolonged low-level cadmium intake and atherosclerosis. 825 93

The endocrine phase of the stress response to cardiopulmonary bypass in children is known to be subtly different from that seen in adults. The aim of this investigation was to determine whether there are similar differences in the acute phase response. Thirteen children were studied (mean age 2.65 years). Each child had congenital heart disease and underwent corrective cardiac surgery. Blood samples taken two days prior to operation and at 6, 9, 12, 24, 48 and 120 hours after were analysed for C-reactive protein, albumin, caeruloplasmin, zinc and copper concentrations. Metal:carrier protein molar ratios were also calculated. Results demonstrate changes which, although similar to those seen in adults, differed both quantitatively and qualitatively. This is explained by the concept of immaturity leading to a generally poor capacity for protein synthesis and a relative inability to respond to altered circumstances.
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PMID:The acute phase response to cardiopulmonary bypass in children. 874 Mar 51

Sudden infant death syndrome (SIDS) is frequently associated with a mild infection, the incidence peaking during the third month of life. We hypothesize that the neonatal immaturity of both the acute febrile response and hypothalamus promote neonatal protection from SIDS. Vagal afferents modify the febrile response. Vagotomized rodents displayed a loss of febrile responsiveness in a 'non-sensing' brain. The failure of a 'non-sensing' brain to react to elevated blood pyrogens leads to failure of the febrile response and to a shock-like state. SIDS infants may appear well yet, within hours of this observation, may be found dead. There is a mismatch between the acute febrile response and hypothalamic hypoactivation. The discrepancy increases with development. There is an elevated cytokine response in endothelial cells which induces nitric oxide (NO) production and retarded development of the hypothalamus. Cigarette smoke also induces NO production and retards hypothalamic development by augmented apoptosis. Zinc inhibits this effect in mouse thymocytes. Fetal haemoglobin (HbF) induces hypoxia, which is a stimulator of the immune response while vasodilator gases (carbon monoxide (CO), NO) reduce hypothalamic function. The hypothalamic failure to sense elevated blood pyrogens induces toxic shock - a feature of SIDS.
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PMID:Sudden infant death syndrome: hypothalamic failure to sense elevated blood pyrogens. 1045 40

In contrast with the full-term infant, the skin of the preterm neonate is structurally and functionally immature, especially birth occurred before 30 weeks gestation. The inefficiency of the epidermal barrier may result in dehydration, thermal instability and toxic reactions from percutaneous absorption of topically applied agents. An increased risk for bacteremia and sepsis exist because of the easily injured skin, combined with compromised immunity. The present article summarizes the consequences of this skin immaturity and the different means to avoid them. We shall also describe 2 pathologies more frequent in premature infants: sclerema neonatorum and acquired zinc deficiency.
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PMID:[Dermatological particularities and pathologies of premature infants]. 1060 18

Sudden infant death syndrome (SIDS) is frequently associated with a mild infection, the incidence peaking during the third month of life. We hypothesize that the neonatal immaturity of both the acute febrile response and hypothalamus promote neonatal protection from SIDS. Vagal afferents modify the febrile response. Vagotomized rodents displayed a loss of febrile responsiveness in a 'non-sensing' brain. The failure of a 'non- sensing' brain to react to elevated blood pyrogens leads to failure of the febrile response and to a shock-like state. SIDS infants may appear well yet, within hours of this observation, may be found dead. There is a mismatch between the acute febrile response and hypothalamic hypoactivation. The discrepancy increase wtih development. There is an elevated cytokine response in endothelial cells which induces nitric oxide (NO) production and retarded development of the hypothalamus. Cigarette smoke also induces NO production and retards hypothalamic development by augmented apoptosis. Zinc inhibits this effect in mouse thymocytes. Fetal haemoglobin (HbF) induces hypoxia which is a stimulator of the immune response, while vasodilator gases (carbon monoxide (CO), NO) reduce hypothalamic function. The hypothalamic failure to sense elevated blood pyrogens induces toxic shock--a feature of SIDS.
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PMID:Sudden infant death syndrome: hypothalamic failure to sense elevated blood pyrogens. 1079 Jul 32

Incidence, hazards and structural variants of pneumopathies according to the findings of 826 autopsies of neonates were studied. Anthropometrical, histological, bacteriological, virusological methods were applied. 17 important elements content in hair and lungs were detected. It was established that incidences of pneumopathies, according to the findings of the autopsies in Tashkent, constitute in total 47,1%. Pulmonary atelectases amount to 57% of all pneumopathies, edematouse-hemorrhagic syndrome--23,5%, aspiration syndrome--10,7%, hyaline membranes--8,8%. The highest lethality from pneumopathies was observed among neonates born from I-III pregnancies with males prevailing. Premature babies were found to have pneumopathies in 77,5%, mature--19%, overmature--3,5%. Risk factors coming from maternal side are the following: extragenital diseases, anemia, chronic pyelonephritis, acute respiratory viral infections, aggravated obstetric anamnesis, placental separation, prolonged early rupture of amniotic fluid sac, delivery by cesarean section. Risk factors coming from the neonate's side are the following: immaturity, intrauterine chronic hypoxia, intrauterine hypotrophy. Deficiency in copper and zinc leading to structural abnormality of pulmonary tissue is of great importance for pathogenesis of separate forms of pneumopathies (pulmonary and hyaline membranes' atelectases).
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PMID:[Incidence, risk factors, and structural variants of pneumopathies in newborns in Tashkent]. 1705 5


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