Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029713 (immaturity)
 4,335 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It has been found that the latency of epileptic seizures caused by glutamate decarboxylase (GAD) inhibitor 3-mercaptopropionate (3-MPA) is markedly longer in immature rats than in the adults. Time course of rat brain GAD inhibition was studied in 12-day-old and adult (90-day-old) animals following 3-MPA (70 mg/kg i.p.). GAD activity was determined by quantification of 14CO2 liberated from [1-(14)C]glutamate by supernatant 20,000 x g of brain homogenate prepared from rats killed at different intervals after 3-MPA administration. In adult rats, the enzyme activity decreased significantly by 14.1% even 1 min after 3-MPA administration and was decreasing gradually till the onset of seizures. In immature rats, GAD activity decrease after 1 min was by 41.4% and further decrease was smaller. Comparison of the time profiles of GAD changes in both groups confirmed our findings that in spite of delayed seizure onset, GAD inhibition in immature rats is more pronounced, probably due to immaturity of the blood-brain barrier.
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PMID:Inhibition of glutamate decarboxylase activity by 3-mercaptopropionic acid has different time course in the immature and adult rat brains. 915 44

By comparison of dopplerometry results of right uterine artery and umbilical cords of a fetus with the histologic and morpho-stereometric data studies of the placenta, and also placental bed and myometrium in an operational material at Cesarian sections, a morphological basis of disturbances of communications in a functional system "mother-placenta-fetus" in hypotonic and hypertonic dysfunction of the uterus is revealed. The morphological picture of chronic placental insufficiency of the fetoplacentary form in the presence of pathological chorion immaturity is revealed in the development of weakness of activity. The uteroplacentary form of chronic placentaly insufficiency, incomplete gestation reorganization MPA and reduction morphometric parameters of a vascular channel miometrium documented formed discoordination of uterine muscles at child birth.
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PMID:[Morphofunctional characteristics of the placenta, placental bed and myometrium in abnormal labor activity]. 1557 82