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Query: UMLS:C0029713 (immaturity)
 4,335 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The lipid composition of leukocytes maintained in long-term culture was examined in order to clarify the role of immaturity in previously observed differences between normal mature leukocytes and leukemic cells. Cell cultures derived from three types of leukocytes were examined: normal lymphocytes, Burkitt lymphoma, and chronic myelocytic leukemia. Lipid extracts were analyzed for total lipid weight, phospholipids, neutral lipids, and glycolipids. Distribution of individual phospholipids was determined by quantitative two-dimensional thin-layer chromatography. The main phospholipids were phosphatidylcholine (51-54%) and phosphatidylethanolamine (24-25%), with smaller amounts of phosphatidylinositol, phosphatidylserine, sphingomyelin, and cardiolipin. All three types of cultured cells showed a remarkable similarity in total phospholipid content (17-18 x 10(-15) moles/cell) as well as in phospholipid distribution. More variation was seen in neutral lipid content. Glycolipid was abundant (17-23% of total lipid weight) and was present mostly as ceramide dihexoside. Compared with normal lymphocytes or polymorphonuclear leukocytes, the cultured cells showed increased phosphatidylcholine, decreased sphingomyelin, and decreased cholesterol content, similar to the changes found in leukemic leukocytes. These findings suggest that the altered lipid patterns found in leukemic leukocytes are a reflection of cell immaturity rather than a characteristic peculiar to the leukemic state.
J Lipid Res 1971 Sep
PMID:Lipid patterns in human leukocytes maintained in long-term culture. 432 7

A survey of differences in composition and metabolism of myelin from five areas of the central nervous system was made in brain and spinal cord slices of the rat from 20 days to 20 months postnatal age. Purified myelin from the forebrain areas showed a composition characteristic of immaturity longer than did myelin from the hindbrain and spinal cord. The trend of chemical maturity is in agreement with the anatomical observations that myelination begins in the hindbrain and proceeds rostrally. Myelin recovery per 100-mg slice increased continually from 20 days to 20 months of age, while the uptake of [1-(14)C]acetate into myelin lipid and of [1-(14)C]leucine into myelin protein decreased precipitously with age. Taking into account the continuous increase in myelin during maturation, a calculation was made of the total amount of incorporation of labeled material into lipids or proteins per 100-mg slice for each region at each age. The metabolic characteristics of myelin from the cerebral cortex (including the corpus callosum), the thalamic area, and the cerebellum were very similar, while myelin from brainstem and spinal cord was metabolically more active, especially at the early ages. Synthesis of lipid in the myelin sheath represents about 50% of the lipid synthesis of the whole brain and about 75% of that of the spinal cord. The proportion of myelin-related protein synthesis is much less, probably less than 10% of the protein synthesis occurring in whole brain and about 15% of that in the spinal cord except at early ages.
J Lipid Res 1973 Sep
PMID:A regional survey of myelin development: some compositional and metabolic aspects. 435 55

A new model of renal cystic disease was developed in newborn Syrian hamsters by the repeated injection of 9-fluoroprednisolone acetate (9-FPA), a long-acting adrenal corticosteroid. Kidneys harvested from the tenth to the fourteenth day of age showed diffuse cystic dilatation of nearly all cortical convoluted tubules. Microdissection revealed that cystic changes primarily involved proximal convoluted tubules and, to a lesser degree, the distal tubules. Electron microscopy showed immaturity of development and varying degrees of degeneration of the cells of the proximal convoluted tubule. Intraluminal obstruction was not detected and therefore could not account for the cystic changes. Analysis of electrolytes in serum and selected tissues showed a significant reduction in potassium and sodium of serum, and significant depletion of potassium, magnesium and calcium in the skeletal muscle. Thus, there was no direct relationship between an electrolyte deficiency and the cystic changes.
Am J Pathol 1973 Sep
PMID:Adrenal corticosteroid-induced renal cystic disease in the newborn hamster. 472 95

The behavioral syndrome called hyperactivity is not outgrown in adolescence. Though excess activity becomes less prominent, emotional immaturity and academic underachievement develop into primary complaints. Antisocial behavior emerges as a serious problem in young adolescents. In late adolescence and early adulthood, many of these individuals apparently improve as they adjust to employment. There is some evidence that older adolescents display no more psychiatric disease or serious delinquency than matched controls. Those adolescents with persistent problems continue to respond favorably to stimulant medication, though often they resist pharmacologic treatment. The clinician is urged to advise patience and supportive tolerance in response to the persisting problems of the adolescent.
J Adolesc Health Care 1983 Sep
PMID:Hyperactivity in adolescence. 635 29

Severe thrombocytopenia, abnormal liver function, and renal dysfunction may occur as manifestations of preeclampsia. Failure to recognize that this cluster of abnormalities represents a form of preeclampsia may result in erroneous initial diagnoses. Management of 13 such patients has shown a direct correlation between the degree of thrombocytopenia and the measures of liver dysfunction. Platelet counts and liver functions improved prior to delivery in five patients treated with corticosteroids. Management should be directed toward investigation and correction of deranged physiology and appropriate monitoring of maternal-feto-placental status. Early delivery is indicated in patients with progressive thrombocytopenia and in those with evidence of fetal maturity or distress. Provided that the disease process remains stable, consideration should be given in cases of fetal immaturity, to the use of betamethasone therapy. The occurrence of severe thrombocytopenia in 20% of neonates should be a consideration in selecting the mode of delivery.
Am J Obstet Gynecol 1984 Sep 01
PMID:Thrombocytopenia in preeclampsia: associated abnormalities and management principles. 647 14

Quantitative studies of selected features of peripherally induced Rickettsia mooseri (= R. typhi) infection in Rattus norvegicus-derived white laboratory rats revealed a unique association between microbe and amplifying vertebrate host which appears to be especially conducive to maintenance of the enzootic cycle. Both adult and newborn (1-3 days old) rats were highly susceptible to percutaneous infection (ID50 = approximately 1 organism), but neither showed signs of disease or died even when inoculated with 10(4)-10(5) plaque-forming units. Gain in body weight of infected newborn rats was indistinguishable from that of uninfected newborn rats over the first 3 weeks of life. The course of the systemic infection, as measured by the rise and fall of R. mooseri titers in blood, brain and kidney and the serum antibody response, was almost identical in adult and newborn rats. Thus, despite their immaturity in certain immunological processes, newborn rats controlled postnatal R. mooseri infection about as well as did adult rats. The rickettsemic period of about 10 days corresponds to the period of infectivity of inoculated rats for fleas. Rickettsiae were not isolated from blood, brain or kidneys by methods employed for more than 4-5 weeks after infection. Serum antirickettsial antibodies persisted for at least 60 weeks postinfection, i.e., longer than the usual life span of rats in nature and, hence, are a valid measure of the cumulative experience of rat populations with R. mooseri infection.
Am J Trop Med Hyg 1984 Sep
PMID:Experimental infection with Rickettsia mooseri and antibody response of adult and newborn laboratory rats. 648 91

In an investigation of developmental trends in the ability to transfer information between the cerebral hemispheres, 138 children, ages 4, 7, and 10, viewed pictures presented to either the right or left hemisphere and were asked to describe what was viewed. Responses were socored for the number of accurate pictorial features reported (inclusion score), confabulation (erroneous embellishment), perceptual, semantic, and syntactic errors. Misses (failure to provide a response) were also noted. A preponderance of errors were found, such that 4-year olds engaged in a significant degree of confabulatory responding following right vs. left presentation. A significant inverse relationship was found between inclusion and confabulation such that the larger the gap in information reported the greater was the tendency to insert (confabulate) erroneous material. In addition, all children were given a tactile-shape recognition task employing both transfer and non-transfer conditions and requiring tactile exploration and visual recognition. Significantly more errors were found on the transfer vs. non transfer task among the 4-year olds only. In that deficits in information transfer were not complete but only partial, and given that significant intra-hemispheric (non-transfer) errors were also discovered, it was concluded that the hemispheres of children age 4 are not completely but only partially disconnected, and that intra-hemispheric (cortical) immaturity plays a significant role in the production of processing deficits.
Cortex 1984 Sep
PMID:Two brains, one child: interhemispheric information transfer deficits and confabulatory responding in children aged 4, 7, 10. 648 10

A case is reported in which serial L/S ratios, determined from fluid samples collected vaginally after premature rupture of the membranes, led to a grossly erroneous conclusion of fetal pulmonary immaturity. The fetus was in breech presentation, and in retrospect several 'amniotic fluid' samples consisted largely of fetal urine. Determination of the creatinine concentration of suspect samples should permit distinction to be made between mixed amniotic fluid and fluid containing a disproportionately large amount of fetal urine when the possibility of this error exists.
Eur J Obstet Gynecol Reprod Biol 1984 Sep
PMID:The L/S ratio in vaginally collected amniotic fluid: a misleading result in a breech presentation. 650 Jan 50

Three infants presented with multiple nodular tumors of the omentum and mesentery characterized histologically by plump mesenchymal cells in a myxoid, well-vascularized stroma. Electron microscopy of one tumor revealed reticulated inclusions in dilated cisterna of endoplasmic reticulum. Diagnoses by the original pathologist, or by consultants from referral centers in the United States included liposarcoma, primitive sarcoma, possible leiomyosarcoma, and fibromatosis, but the subsequent evolution of the patients questions the validity of such diagnoses. Two patients received what was deemed ineffective therapy, yet survived with no evidence of disease for over a decade of close follow-up. Another patient received no therapy other than the initial surgery, and has been well for more than a year. Infantile lesions may show deceptive features of immaturity and high cellularity that are apt to be confused with a true malignancy. Omentalmesenteric "myxoid" lesions are probably hamartomatous in origin.
Am J Surg Pathol 1983 Sep
PMID:Omental-mesenteric myxoid hamartomas. Infantile lesions simulating malignant tumors. 662 50

Children vaccinated when aged between six and thirteen months against measles in Taipei showed a high frequency of response, similar to that reported from Nairobi, Kenya and contrasting with analogous data for the USA. The age for optimal protection against measles mortality by a single dose of vaccine in this group of children is nine months. Maternal antibody exerted a negative effect on measles antibody titre in vaccinees beyond the age at which it blocked the response so that the infants of mothers with the higher titres themselves had lower titres. A separate effect of immunological immaturity on titre of the response could not be demonstrated in children over six months of age.
Int J Epidemiol 1983 Sep
PMID:The optimal age for vaccination against measles in an Asiatic city, Taipei, Taiwan: reduction of vaccine induced titre by residual transplacental antibody. 662 23


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