Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029713 (immaturity)
 4,335 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The concentrations of palmitic acid, derived from lecithin, and of cortisol in samples of amniotic fluid collected during the last trimester of human pregnancy, ranged from 28 to 420 mumol/l and from 16 to 104 nmol/l, respectively. There was a weak (r = 0.43) but significant (p less than 0.01) correlation between the concentrations of cortisol and palmitate in the samples. Measurement of the cortisol concentration in amniotic fluid provided an unreliable index of pulmonary immaturity, whether this was assessed with reference to the concentration of palmitate or from subsequent development of the respiratory distress syndrome. Measurement of cortisol in amniotic fluid cannot be recommended for this purpose.
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PMID:Comparisons of the concentrations of palmitate and cortisol in amniotic fluid for the prediction of pulmonary maturity. 62 Apr 62

Lambs prematurely delivered by cesarean section and term lambs were supported on ventilators and studied over a period of 2 days. Sequential measurements of ventilatory requirements, lung compliance, and arterial pH, pO2, and pCO2 values documented the course of the lung disease. In five premature lambs the pCO2 increased to 77 +/- 5 mm Hg (mean +/- SE) by 40.5 +/- 3.1 hr of age, at which time treatment with 50 mg natural sheep surfactant lipid/kg body weight by tracheal instillation resulted in improvements in pH, pO2, and pCO2 measurements. Radiolabeled palmitic acid was injected systemically after birth to detect the appearance of endogenously synthesized and secreted saturated phosphatidylcholine in sequential airway samples. Radiolabeled saturated phosphatidylcholine specific activity increased in a relatively linear fashion for about 30 hr in lambs treated with natural surfactant, in untreated premature lambs, and in term lambs. The study demonstrates that surfactant therapy can improve the ventilatory status of premature lambs despite many hours of ventilation for pulmonary immaturity. The overall kinetics of secretion of saturated phosphatidylcholine is similar in lambs with and without pulmonary immaturity.
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PMID:Saturated phosphatidylcholine secretion and the effect of natural surfactant on premature and term lambs ventilated for 2 days. 655 78

A vegetable oil fat blend resulting in formula major fatty acid levels similar to human milk is appropriate for infant feedings even though the palmitic acid may have a somewhat different positional distribution. Growth, bone mineral content, and visual acuity (as measured by the Teller acuity card procedure) achieved in normal infants consuming such formulas are at least as good as those from human milk. The quantitatively minor LC-PUFA levels may also be important in infant development and useful once safety of their sources has been adequately demonstrated. Such formula fat blends mimicking the major fatty acid profiles of human milk are appropriate for infants with relatively normal fat absorptive mechanisms including infants with allergy or inborn errors of metabolism. Formulas designed for such infants (e.g., extensively hydrolyzed protein products for allergic infants) do not need to have MCT oil included in the formulation which alters the fatty acid profile. On the other hand, those infants with immaturity, gastrointestinal disease, and/or fat malabsorption often do benefit by the inclusion of MCT oil in the fat blend of the formula.
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PMID:Challenges of matching human milk fatty acid patterns technically and functionally. 908 18