Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029713 (immaturity)
 4,335 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of non-secretory multiple myeloma presenting as primary plasma cell leukaemia in a 65 year old woman is presented. Bone pain was the initial clinical manifestation. Laboratory analysis showed 20% of circulating immature plasma cells. Despite the presence of osteolytic lesions, no M-component could be demonstrated in serum protein electrophoresis, and serum and urine immunoelectrophoresis. Bone marrow aspirate demonstrated an 83% infiltration of plasma cells showing various degrees of immaturity. Immunofluorescence with monoclonal antisera demonstrated intracytoplasmic kappa light chains in a high percentage of plasma cells. Immature plasma cells without cellular capacity to synthesize and excrete complete immunoglobulins could be more aggressive, leading to an initial leukaemic process. Previous work regarding possible pathogenetic mechanisms, clinical and laboratory features, and response to treatment of this extremely rare association are reviewed.
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PMID:Non-secretory multiple myeloma presenting as primary plasma cell leukaemia. 143 33

Whole blood levels, serum protein binding and tissue concentration following intravenous administration of warfarin were investigated in 1-d-old, 1-, 3- and 8-week-old rats to determine the drug disposition in the growth process. It was shown that the clearance of warfarin in 1-d-old or 1-week-old rats was considerably lower than that in 3- or 8-week-old rats. The decrease in clearance in infant and young rats was considered to be caused by the immaturity of the physiological function of the liver to remove exogenous compounds. The distribution volume in 1-d-old or 1-week-old rats was larger than that in 3- or 8-old rats. The percentages of serum free warfarin in 1-d-old and 1-week-old rats were about twice those in 3- and 8-week-old rats. The increased distribution volume in infant rats was considered to be caused by a lower serum protein binding in these rats.
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PMID:Age-dependent changes in warfarin tissue distribution. 355 79