Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029713 (immaturity)
 4,335 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Prolonged infusion of the beta 2-adrenergic agonist, ritodrine, into sheep during late pregnancy decreased maternal plasma K+ from 3.6 to 2.5 mmol l-1 during the first 6-8 h of infusion, as it does during tocolysis in women. This decrease was not accompanied by significant change in fetal plasma K+ concentration. Ritodrine infusion (1-3.5 micrograms kg-1 min-1) directly into the fetus also did not decrease fetal plasma K+ significantly. In contrast, insulin (2.5 mU kg-1 min-1), infused together with glucose (3.6 mg kg-1 min-1) directly into the fetus decreased fetal plasma K+ concentration by 0.8 mmol l-1 within 1 h. The results suggest immaturity in beta 2-adrenergic receptor regulation of electrogenic K+ uptake by muscle in fetal lambs.
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PMID:Effects of the beta-adrenergic agonist, ritodrine, and insulin on plasma potassium concentrations in fetal lambs. 135 75