Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0029713 (immaturity)
 4,335 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The new international classification of the different stages of RLF is presented. The incidence of ROP varies between 10 and 80/100,000 live births, and 7 and 40% of all prematures. Recent data from Switzerland indicate that 12% of the 7-16 years old scholars in schools for visually disabled children have advanced stages of ROP (RLF). 27% of the totally blind scholars have RLF. The main risk factors are immaturity of retinal vascularization and oxygen. Other postulated risk factors like f.e. elevated or fluctuating pCO2 are discussed. Indications and a time schedule for ophthalmological examination are suggested. Prophylactic measures as f.e. Vitamin E administration are briefly mentioned. Finally, ophthalmological treatment is critically evaluated. An efficiency of coagulation has not yet been proven. An uncomplicated retinal detachement can be treated with conventional retinal surgery if it does not regress spontaneously during the course of active ROP. Chances to gain visual benefit from extreme vitreo-retinal surgery of endstage RLF with total retinal detachement cannot yet fully be estimated but seem to be very low.
 ...
PMID:[Retinopathy of prematurity]. 309 36

Newborns requiring intensive clinical care are susceptible to a wide range of excessive oxygen free radical production-related problems. In utero, fetal organs, particularly lungs, are exposed to relatively hypoxic tensions which rise abruptly after birth and this transition may cause oxidative injury in the neonate. The aims of this study were to determine oxygen free radical activity in neonates at the first 24 h, examine the role of immaturity and infection risk and compare the degree of oxidant stress in newborns treated with different oxygen concentrations. Plasma selenium levels in neonates with high infection risk (IR) were significantly lower than in healthy neonates. Comparative study of selenium in preterm, term and young infants showed age-related increases and differences were significant. Plasma selenium values were lower when oxygen therapy was administered. Vitamin E levels were significantly decreased in IR compared with healthy newborns. The results suggest that selenium and vitamin E deficiencies predispose to neonatal infection and that supplementary oxygen contributes significantly to decreasing the antioxidant defence system.
 ...
PMID:Impact of oxygen therapy on antioxidant status in newborns. Relationship with infection risk. 969 23