Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0029713 (
immaturity
)
4,335
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The in vitro effect of indomethacin (IM) and ibuprofen (IB) on the production of the
interleukin-1 receptor antagonist
(
IL-1ra
) by cord blood mononuclear cells (CBMC) from preterm newborns was compared to that of peripheral blood mononuclear cells (PBMC) from adults. Mononuclear cells (MC) were incubated with lipopolysaccharide (LPS) in the absence or presence of various concentrations of IM and IB. The level of
IL-1ra
in the supernatants was tested by ELISA. The results showed a lower ability of MC from preterm newborns to produce
IL-1ra
as compared with adult cells, supporting the assumption of neonatal immune cell
immaturity
. IM at pharmacological concentrations caused inhibition of
IL-1ra
secretion by PBMC from adults whereas IB suppressed the secretion of
IL-1ra
at higher concentrations only. At the same concentrations neither drug had an in vitro effect on the production of
IL-1ra
by CBMC of preterm newborns. In conclusion, the lower ability of CBMC of preterm newborns to produce
IL-1ra
in response to LPS and the absence of an IM and IB effect on the secretion of this cytokine by these cells as compared with PBMC of adults, suggest an underdevelopment of the immune response in preterm newborns.
...
PMID:Indomethacin and ibuprofen effect on IL-1ra production by mononuclear cells of preterm newborns and adults. 1216 27
