Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0029713 (
immaturity
)
4,335
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
It has recently become possible to generate chimeric mice durably engrafted with many components of the human immune system (
HIS
mice). We have characterized the maturation and function of the B cell compartment of
HIS
mice. The antibody response of
HIS
mice to T cell-dependent B cell antigens is limited, and contributing factors may be the general
immaturity
of the B cell compartment, infrequent helper T cells selected on human MHC class II antigens, and incomplete reconstitution of secondary lymphoid organs and their microenvironments. In contrast,
HIS
mice generate protective antibody responses to the bacterium Borrelia hermsii, which acts as a T cell-independent antigen in mice, but do not respond to purified polysaccharide antigens (PPS). We speculate that the anti-B. hermsii response of
HIS
mice is derived from an abundant B cell subset that may be analogous to B1 B cells in mice. We suggest that failure of
HIS
mice to respond to PPS is due to the lack of a B cell subset that may originate from adult bone marrow and is highly dependent on human interleukin-7 for development.
...
PMID:Human immune system mice: current potential and limitations for translational research on human antibody responses. 2203 27
