Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029713 (immaturity)
 4,335 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It appears certain that the causes of self-destructive dermatoses are many and complex. The disorder spans diagnostic categories and varies from unconscious picking at the skin to severe self-destructive actions. Although not limited to any one diagnosis, skin disorders appear to be more prevalent in depression. This association may involve activation of the hypothalamic-pituitary-adrenal axis commonly found in depression. Two specific types of commonly occurring dermatoses-neurotic excoriations and dermatitis artefacta-are reviewed in this article. The major distinction of these disorders centers on whether the patient can admit to self-mutilation. Because of the difficulties in dermatitis artefacta with insight and body-image, it has been compared with anorexia nervosa. Often, dermatitis artefacta coexists with anorexia nervosa. In both disorders, neurotic excoriations and dermatitis artefacta, the personality style tends to be introverted with emotional immaturity. These patients have difficulty when they are under stress; the problem is compounded because of poor communication skills. Pharmacotherapy is of limited usefulness, and psychotherapy is often times hindered by strong resistance to exploring long-standing emotional issues. Once an alliance is established with the therapist, however, these issues may be examined. Prognosis is variable but does seem to directly correlate with the duration of the illness. Young individuals may experience alleviation of symptoms after one session of psychotherapy, whereas older patients may never have resolution. Dermatologic abuse involving psychosis has many presentations; one of the most common involves infestation. Organic causes must always be excluded as part of the differential diagnosis. In schizophrenia, this presentation has one of the highest incidences of suicide.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Self-destructive dermatoses. 389 93

Electron dense bodies and vesicles were increased in undifferentiated crypt cells and differentiated colonocytes in the rectal mucosa of healthy volunteers in southern India. In addition, in the surface colonocytes lysosomes were increased, the cells were shorter with short irregularly grouped microvilli, there was evidence of cell immaturity and a high prevalence of spiral organism infestation. There was also alterations in goblet cell mucus granules, a reticulohistiocytic response in the subluminal lamina propria and residual evidence of vascular damage. These alterations indicate a non-specific response to mucosal injury. Such changes have not been observed in the rectal mucosa of temperate zone controls and could be designated tropical colonopathy.
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PMID:Rectal mucosal morphologic abnormalities in normal subjects in southern India: a tropical colonopathy? 401 35